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Cognitive Neurodynamics
Erschienen in: Cognitive Neurodynamics 5/2012

01.10.2012 | Research Article

Bursts shape the NMDA-R mediated spike timing dependent plasticity curve: role of burst interspike interval and GABAergic inhibition

verfasst von: Vassilis Cutsuridis

Erschienen in: Cognitive Neurodynamics | Ausgabe 5/2012

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Abstract

Spike timing dependent plasticity (STDP) is a synaptic learning rule where the relative timing between the presynaptic and postsynaptic action potentials determines the sign and strength of synaptic plasticity. In its basic form STDP has an asymmetric form which incorporates both persistent increases and persistent decreases in synaptic strength. The basic form of STDP, however, is not a fixed property and depends on the dendritic location. An asymmetric curve is observed in the distal dendrites, whereas a symmetrical one is observed in the proximal ones. A recent computational study has shown that the transition from the asymmetry to symmetry is due to inhibition under certain conditions. Synapses have also been observed to be unreliable at generating plasticity when excitatory postsynaptic potentials and single spikes are paired at low frequencies. Bursts of spikes, however, are reliably signaled because transmitter release is facilitated. This article presents a two-compartment model of the CA1 pyramidal cell. The model is neurophysiologically plausible with its dynamics resulting from the interplay of many ionic and synaptic currents. Plasticity is measured by a deterministic Ca2+ dynamics model which measures the instantaneous calcium level and its time course in the dendrite and change the strength of the synapse accordingly. The model is validated to match the asymmetrical form of STDP from the pairing of a presynaptic (dendritic) and postsynaptic (somatic) spikes as observed experimentally. With the parameter set unchanged the model investigates how pairing of bursts with single spikes and bursts in the presence or absence of inhibition shapes the STDP curve. The model predicts that inhibition strength and frequency are not the only factors of the asymmetry-to-symmetry switch of the STDP curve. Burst interspike interval is another factor. This study is an important first step towards understanding how STDP is affected under natural firing patterns in vivo.
Vorheriger Artikel Dynamic characteristics of multisensory facilitation and inhibition
Nächster Artikel Mean square stability of uncertain stochastic BAM neural networks with interval time-varying delays

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Metadaten
Titel
Bursts shape the NMDA-R mediated spike timing dependent plasticity curve: role of burst interspike interval and GABAergic inhibition
verfasst von
Vassilis Cutsuridis
Publikationsdatum
01.10.2012
Verlag
Springer Netherlands
Erschienen in
Cognitive Neurodynamics / Ausgabe 5/2012
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-012-9205-1

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