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Erschienen in: Neural Computing and Applications 7/2020

13.09.2019 | Deep Learning & Neural Computing for Intelligent Sensing and Control

Classification of Alzheimer’s disease based on brain MRI and machine learning

verfasst von: Zhao Fan, Fanyu Xu, Xuedan Qi, Cai Li, Lili Yao

Erschienen in: Neural Computing and Applications | Ausgabe 7/2020

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Abstract

Alzheimer’s disease (AD) is one of the most common diseases in the world. It is a neurodegenerative disease that can cause cognitive impairment and memory deterioration. In recent years, the number of the elderly population is increasing, and the incidence of elderly diseases has increased significantly. The most representative of these diseases is Alzheimer’s disease. According to some data, the average survival time of Alzheimer’s disease patients is only 5.5 years, which is the “fourth killer” that endangers the health of the elderly after cardiovascular diseases, cerebrovascular diseases and cancer. According to conservative estimates of the International Federation of Alzheimer’s Diseases, the number of Alzheimer’s disease patients worldwide will increase to 75.62 million by 2030; by 2050, the number of patients will reach 135.46 million. Therefore, it is urgent to classify the course of Alzheimer’s disease. In this paper, support vector machine (SVM) model method is used to classify and predict different disease processes of Alzheimer’s disease based on structural brain magnetic resonance imaging (MRI) imaging data, so as to help the auxiliary diagnosis of the disease. In this paper, the extracted MRI data and the SVM model are combined to obtain more accurate classification prediction results. The accuracy of classification and prediction is the best. According to the predicted results, the data characteristics related to diseases can be determined, which can provide a basis for clinical and basic research, etiology and pathological changes.

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Literatur
1.
Zurück zum Zitat Reitz C, Mayeux R (2014) Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol 88(4):640–651CrossRef Reitz C, Mayeux R (2014) Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol 88(4):640–651CrossRef
2.
Zurück zum Zitat Green RC, Cupples LA, Kurz A et al (2016) Depression as a risk factor for Alzheimer disease: the MIRAGE study. Arch Neurol 60(5):753CrossRef Green RC, Cupples LA, Kurz A et al (2016) Depression as a risk factor for Alzheimer disease: the MIRAGE study. Arch Neurol 60(5):753CrossRef
3.
Zurück zum Zitat Bloom GS (2014) Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71(4):505–508CrossRef Bloom GS (2014) Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71(4):505–508CrossRef
4.
Zurück zum Zitat Lucía CG, Leen B, Iryna B et al (2014) The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J 31(10):2261–2274 Lucía CG, Leen B, Iryna B et al (2014) The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J 31(10):2261–2274
5.
Zurück zum Zitat Tarasoffconway JM, Carare RO, Osorio RS et al (2016) Clearance systems in the brain—implications for Alzheimer disease. Nat Rev Neurol 12(4):248CrossRef Tarasoffconway JM, Carare RO, Osorio RS et al (2016) Clearance systems in the brain—implications for Alzheimer disease. Nat Rev Neurol 12(4):248CrossRef
6.
Zurück zum Zitat Ferrucci R, Mameli F, Guidi I et al (2016) Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology 71(7):493–498CrossRef Ferrucci R, Mameli F, Guidi I et al (2016) Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology 71(7):493–498CrossRef
7.
Zurück zum Zitat Ujiie M, Dickstein DL, Carlow DA et al (2015) Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Neurobiol Aging 25(6):S236–S236 Ujiie M, Dickstein DL, Carlow DA et al (2015) Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Neurobiol Aging 25(6):S236–S236
8.
Zurück zum Zitat Barker WW, Luis CA, Kashuba A et al (2015) Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 16(4):203–212CrossRef Barker WW, Luis CA, Kashuba A et al (2015) Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 16(4):203–212CrossRef
9.
Zurück zum Zitat Tariot PN, Farlow MR, Grossberg GT et al (2014) Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. Chin J Gen Pract 291(3):317–324 Tariot PN, Farlow MR, Grossberg GT et al (2014) Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. Chin J Gen Pract 291(3):317–324
10.
Zurück zum Zitat Tromp D, Dufour A, Lithfous S et al (2015) Episodic memory in normal aging and Alzheimer disease: insights from imaging and behavioral studies. Ageing Res Rev 24(Pt B):232–262CrossRef Tromp D, Dufour A, Lithfous S et al (2015) Episodic memory in normal aging and Alzheimer disease: insights from imaging and behavioral studies. Ageing Res Rev 24(Pt B):232–262CrossRef
11.
Zurück zum Zitat Butterfield DA, Domenico FD, Barone E (2014) Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Biochim Biophys Acta 1842(9):1693–1706CrossRef Butterfield DA, Domenico FD, Barone E (2014) Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain. Biochim Biophys Acta 1842(9):1693–1706CrossRef
12.
Zurück zum Zitat Rd DD III, Jerskey BA, Chen K et al (2014) Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. JAMA Neurol 71(1):11CrossRef Rd DD III, Jerskey BA, Chen K et al (2014) Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. JAMA Neurol 71(1):11CrossRef
13.
Zurück zum Zitat Takeda S, Sato N, Morishita R (2014) Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci 6(6):171 Takeda S, Sato N, Morishita R (2014) Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Front Aging Neurosci 6(6):171
14.
Zurück zum Zitat Willette AA, Bendlin BB, Starks EJ et al (2015) Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurol 72(9):1013CrossRef Willette AA, Bendlin BB, Starks EJ et al (2015) Association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for Alzheimer disease. JAMA Neurol 72(9):1013CrossRef
15.
Zurück zum Zitat Kester MI, Goos JD, Teunissen CE et al (2014) Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers. JAMA Neurol 71(7):855–862CrossRef Kester MI, Goos JD, Teunissen CE et al (2014) Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers. JAMA Neurol 71(7):855–862CrossRef
16.
Zurück zum Zitat Tramutola A, Triplett JC, Domenico FD et al (2015) Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. J Neurochem 133(5):739–749CrossRef Tramutola A, Triplett JC, Domenico FD et al (2015) Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. J Neurochem 133(5):739–749CrossRef
17.
Zurück zum Zitat Wang LY, Raskind MA, Wilkinson CW et al (2018) Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia. Int J Geriatr Psychiatry 33(5):763CrossRef Wang LY, Raskind MA, Wilkinson CW et al (2018) Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia. Int J Geriatr Psychiatry 33(5):763CrossRef
18.
Zurück zum Zitat Prestia A, Caroli A, Wade SK et al (2015) Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics. Alzheimers Dement J Alzheimers Assoc 11(10):1191–1201CrossRef Prestia A, Caroli A, Wade SK et al (2015) Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics. Alzheimers Dement J Alzheimers Assoc 11(10):1191–1201CrossRef
19.
Zurück zum Zitat Peskind ER, Tsuang DW, Bonner LT et al (2015) Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study. Alzheimer Dis Assoc Disord 19(1):23–28CrossRef Peskind ER, Tsuang DW, Bonner LT et al (2015) Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: a placebo-controlled study. Alzheimer Dis Assoc Disord 19(1):23–28CrossRef
20.
Zurück zum Zitat Carnevale L, D’Angelosante V, Landolfi A et al (2018) Brain MRI fiber-tracking reveals white matter alterations in hypertensive patients without damage at conventional neuroimaging. Cardiovas Res 114(11):1536–1546CrossRef Carnevale L, D’Angelosante V, Landolfi A et al (2018) Brain MRI fiber-tracking reveals white matter alterations in hypertensive patients without damage at conventional neuroimaging. Cardiovas Res 114(11):1536–1546CrossRef
21.
Zurück zum Zitat Amlerova J, Cavanna AE, Bradac O et al (2014) Emotion recognition and social cognition in temporal lobe epilepsy and the effect of epilepsy surgery. Epilepsy Behav 36(36):86–89CrossRef Amlerova J, Cavanna AE, Bradac O et al (2014) Emotion recognition and social cognition in temporal lobe epilepsy and the effect of epilepsy surgery. Epilepsy Behav 36(36):86–89CrossRef
22.
Zurück zum Zitat Liu WF, Wang X, Xia H (2014) 3D texture analysis of Corpus Caliosum based on MR images inpatients with Alzheimer’s disease and mild cognitive impairment. Appl Mech Mater 533:415–420CrossRef Liu WF, Wang X, Xia H (2014) 3D texture analysis of Corpus Caliosum based on MR images inpatients with Alzheimer’s disease and mild cognitive impairment. Appl Mech Mater 533:415–420CrossRef
23.
Zurück zum Zitat Yu L, Xia H, Liu W (2016) Classification studies in patients with Alzheimer’s disease and normal control group based on three-dimensional texture features of hippocampus magnetic resonance images. J Biomed Eng 33(6):1090–1094 Yu L, Xia H, Liu W (2016) Classification studies in patients with Alzheimer’s disease and normal control group based on three-dimensional texture features of hippocampus magnetic resonance images. J Biomed Eng 33(6):1090–1094
24.
Zurück zum Zitat Chen Z, Chen X, Chen Z et al (2017) Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimensional texture analysis. J Headache Pain 18(1):112CrossRef Chen Z, Chen X, Chen Z et al (2017) Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimensional texture analysis. J Headache Pain 18(1):112CrossRef
25.
Zurück zum Zitat Leandrou S, Petroudi S, Kyriacou PA et al (2018) Quantitative MRI brain studies in mild cognitive impairment and Alzheimer’s disease: a methodological review. IEEE Rev Biomed Eng 11(99):97CrossRef Leandrou S, Petroudi S, Kyriacou PA et al (2018) Quantitative MRI brain studies in mild cognitive impairment and Alzheimer’s disease: a methodological review. IEEE Rev Biomed Eng 11(99):97CrossRef
26.
Zurück zum Zitat Liu Z, Lv L, Yong W (2017) Development of face recognition system based on PCA and LBP for intelligent anti-theft doors. In: IEEE International conference on computer and communications Liu Z, Lv L, Yong W (2017) Development of face recognition system based on PCA and LBP for intelligent anti-theft doors. In: IEEE International conference on computer and communications
27.
Zurück zum Zitat Wang Q (2016) Design and implementation of remote facial expression recognition surveillance system based on PCA and KNN algorithms. In: International conference on intelligent information hiding and multimedia signal processing Wang Q (2016) Design and implementation of remote facial expression recognition surveillance system based on PCA and KNN algorithms. In: International conference on intelligent information hiding and multimedia signal processing
28.
Zurück zum Zitat Guo-Jun MA, Zhou HD (2015) Research and implementation of intelligent terminal lightweight face recognition system. J Commun 5(6):119–134 Guo-Jun MA, Zhou HD (2015) Research and implementation of intelligent terminal lightweight face recognition system. J Commun 5(6):119–134
29.
Zurück zum Zitat Liang X (2019) A medical diagnostic expert system with LPSO-based artificial neural network. Investigación Clínica 60(4):894–899 Liang X (2019) A medical diagnostic expert system with LPSO-based artificial neural network. Investigación Clínica 60(4):894–899
Metadaten
Titel
Classification of Alzheimer’s disease based on brain MRI and machine learning
verfasst von
Zhao Fan
Fanyu Xu
Xuedan Qi
Cai Li
Lili Yao
Publikationsdatum
13.09.2019
Verlag
Springer London
Erschienen in
Neural Computing and Applications / Ausgabe 7/2020
Print ISSN: 0941-0643
Elektronische ISSN: 1433-3058
DOI
https://doi.org/10.1007/s00521-019-04495-0

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