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Erschienen in:
2008 | OriginalPaper | Buchkapitel
Computer-Aided Delivery of High-Intensity Focused Ultrasound (HIFU) for Creation of an Atrial Septal Defect in Vivo
verfasst von : Hiromasa Yamashita, Tetsuko Ishii, Akihiko Ishiyama, Noriyoshi Nakayama, Toshinobu Miyoshi, Yoshitaka Miyamoto, Gontaro Kitazumi, Yasumasa Katsuike, Makoto Okazaki, Takashi Azuma, Masayuki Fujisaki, Shinichi Takamoto, Toshio Chiba
Erschienen in: Medical Imaging and Augmented Reality
Verlag: Springer Berlin Heidelberg
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In recent years, several fetal cardiac malformations have been increasingly treated before birth with gradually improved outcome, although the technique is still demanding and invasive. We newly developed a computer-aided system for energy delivery of high-intensity focused ultrasound (HIFU) to correct cardiac morphologic abnormalities
in vivo
much less invasively. The HIFU system could be controlled in real-time by a computer-based analysis of 2D-sonographic left ventricular images for optimal triggering off HIFU. Using beating heart of two anesthetized adult rabbits, the system successfully achieved a non-touch gross ablation of the atrial septum in one animal, and in the other HIFU energy was inadvertently mistargeted on the posterior wall of the left atrium with a resultant small transmural opening. We believe that the HIFU system will be introduced with pinpoint accuracy to minimally invasive treatment of fetal cardiac abnormalities that have intact or highly restrictive atrial septum.