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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 8/2021

01.08.2021 | ORIGINAL PAPER

Construction of β-cyclodextrin linked glycidyl methacrylate polymers for stereoselective separation of chiral drug

verfasst von: Apparav Wale, Khudbudin Mulani, Supriya Deshpande, C. R. Rajan, Surendra Ponrathnam

Erschienen in: Journal of Polymer Research | Ausgabe 8/2021

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Abstract

In this present study, a series of cross-linked porous polymers based on Glycidyl Methacrylate (GMA) were synthesized by suspension polymerization using cyclohexanol and hexanol as pore generating solvents. β-cyclodextrin (β-CD) was covalently bonded to the polymers by using Hexamethylene Diisocyanate (HMDI) and Sebacoyl Chloride (SC) as spacer arms. The effects of matrix properties such as pore volume, type of crosslinker, and spacer on the loading of β-cyclodextrin were investigated. The stereoselective binding of enantiomers of the anti-depressant drug citalopram was studied using β-cyclodextrin loaded polymers under batch adsorption mode. The capacity factor and selectivity of isomers were investigated also. This study reveals that these β-cyclodextrin bonded Glycidyl Methacrylate (GMA) polymers are potentially suitable for chromatographic separation of citalopram.
Vorheriger Artikel Hydrogels of Acryloyl guar gum-g-(acrylic acid-co-3sulfopropylacrylate) for high-performance adsorption and release of gentamicin sulphate
Nächster Artikel Self-assembled drug-polymer micelles with NO precursor loaded for synergistic cancer therapy

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Literatur
1.
Ahuja S (1991) Chiral separations by chromatography, American Chemical Society, Washington D. C. Ch.1
2.
Easson L, Stedman E (1933) Studies on the relationship between chemical constitution and physiological action. Biochem J 27(4):1257–1266CrossRef
3.
Eliel E, Wilen S, Mander L (2003) Stereochemistry of organic compounds, Ch.7, pp 309
4.
Cakmak R, Ercan S, Sunkur M, Yilmaz H (2017) Design, preparation and application of a Pirkle-type chiral stationary phase for enantioseparation of some racemic organic acids and molecular dynamics studies. Org Commun 10(3):216–227CrossRef
5.
Okamoto Y, Hatada K, Kawashima M (1984) Chromatographic resolution. 7. Useful chiral packing materials for high-performance liquid chromatographic resolution of enantiomers: phenylcarbamates of polysaccharides coated on silica gel. J Am Chem Soc 106:185357–185359CrossRef
6.
Lipkowitz KB, Green K, Yang J, Pearl G, Peterson MA (1993) Theoretical study of enantiodifferentiation in solid state cyclodextrins. Chirality 5:51CrossRef
7.
Rahim N, Tay K, Mohamad S (2016) β-Cyclodextrin functionalized ionic liquid as chiral stationary phase of high performance liquid chromatography for enantioseparation of β-blockers. J Incl Phenom Macrocycl Chem 85:303–315CrossRef
8.
Xiao Y, Ng S, Tan T (2012) Recent development of cyclodextrin chiral stationary phases and their applications in chromatography. J Chromatogr A 1269
9.
Nawrocki J (1997) The silanol group and its role in liquid chromatography. J Chromatogr A 779:1–2CrossRef
10.
Svec F, Hradil J, Coupek J, Kalal J (1975) Reactive polymers I. Macroporous methacrylate Copolymer containing epoxy groups. Die Angewante macromolecular Chemie 48:135
11.
Liu D, Zhang T, Cheng Y, Jia Q (2014) Poly(glycidyl methacrylate-co-N-methylolacrylamide-co-ethylene dimethacrylate) monolith coupled to high-performance liquid chromatography for the determination of adenosine phosphates in royal jelly. J Sep Sci 37(14):1826CrossRef
12.
Tasfiyati A, Iftitah E, Sakti S, Sabarudin A (2016) Evaluation of glycidyl methacrylate-based monolith functionalized with weak anion exchange moiety inside 0.5 mm i.d. column for liquid chromatographic separation of DNA. Anal Chem Res 7:9–16CrossRef
13.
Aversa T, Silva C, Rocha P, Lucas E (2016) Influence of exchange group of modified glycidyl methacrylate polymer on phenol removal: A study by batch and continuous flow processes. J Environ Manage 182(1):301CrossRef
14.
Muzammil E, Khan A, Stuparu M (2017) Post-polymerization modification reactions of poly(glycidyl methacrylate)s. RSC Adv 7:55874CrossRef
15.
Rolland A, Hérault D, Touchard F, Saluzzo C, Duval R, Lemaire M (2001) Enantiopure poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate): a new material for supported catalytic asymmetric hydrogen transfer reduction. Tetrahedron: Asymmetry 12:811
16.
Kimmins S, Wyman P, Cameron N (2014) Amine-functionalization of glycidyl methacrylate-containing emulsion-templated porous polymers and immobilization of proteinase K for biocatalysis. Polymer 55(1):416–425CrossRef
17.
Thudi L, Jasti L, Swarnalatha Y, Fadnavis N, Mulani K, Deokar S, Ponrathnam S (2012) Enzyme immobilization on epoxy supports in reverse micellar media: Prevention of enzyme denaturation. J Mol Catal B Enzym 74(1–2):54
18.
Radivoje P, Slobodan J, Zoran V (2001) Immobilization of invertase on a new type of macroporous glycidyl methacrylate. Biotechnol Lett 23:1171CrossRef
19.
Alharthi S, Rassi Z (2020) Various Strategies in Post-Polymerization Functionalization of Organic Polymer-Based Monoliths Used in Liquid Phase Separation Techniques. Molecules 25(6):1323CrossRef
20.
Jialiang G, Yuan X, Yuanjinh L, Jacques C, Zhengjin J (2016) Effect of the crosslinker type on the enantioseparation performance of β-cyclodextrin functionalized monoliths prepared by the one-pot approach. J Chromatgr A 1467:288–296CrossRef
21.
Wei Z, Bofeng W, Shoujiang L, Yueming W, Shaoyan W (2017) Preparation and Chromatographic Application of β-Cyclodextrin Molecularly Imprinted Microspheres for Paeoniflorin. Polymers 9(6):214CrossRef
22.
Montgomery SA, Loft H, Sanchez C, Reines EH, Papp M (2001) Escitalopram (S-Enantiomer of Citalopram): Clinical Efficacy and Onset of Action Predicted from a Rat Model. Pharmacol Toxicol 88:282–286CrossRef
23.
Dubois M, Gilles KA, Hamilton JK (1956) Colorimetric Method for Determination of Sugars and Related Substances. Anal Chem 28:350CrossRef
24.
Okay O (2000) Macroporous copolymer networks. Prog Polym Sci 25:711–779CrossRef
25.
Qi T, Sonoda A, Makita Y, Kanoh H, Ooi K, Hirotsu T (2002) Porous properties of poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) resins synthesized by suspension polymerization. J Appl Polym Sci 83:2374–2381CrossRef
26.
Brunauer S, Deming LS, Deming WS, Teller E (1940) Theory of the van der Waals Adsorption of Gases. J Am Chem Soc 62:1723–1732CrossRef
27.
Hirotsu T (2006) Plasma graft polymerization of glycidyl methacrylate and cyclodextrin immobilization. Thin Solid Films 506:173CrossRef
28.
Kim M, Way JD, Baldwin M (2004) Effects of cross-linking and spacer groups on beta-cyclodextrin bonded liquid chromatographic separation. Korean J Chem Eng 21:465CrossRef
29.
Muderawan WI, Ong T (2006) Urea bonded cyclodextrin derivatives onto silica for chiral HPLC. J Sep Sci 29:1849CrossRef
30.
Lui Y, Fan X, Gao L (2003) Synthesis and Characterization of β-Cyclodextrin Based Functional Monomers and its Copolymers with N-isopropylacrylamide. Macromol Biosci 3:715CrossRef
31.
Ali SM, Maheshwari A, Fozdar BI (2007) 1H NMR spectroscopic study of complexation of citalopram with β-cyclodextrin in aqueous solution. Magn Reson Chem 45:253–256CrossRef
32.
Kosel M, Eap CB, Amey M, Baumann P (1998) Analysis of the enantiomers of citalopram and its demethylated metabolites using chiral liquid chromatography. J Chromatogr B 719:234–238CrossRef
33.
Lomberg LG, Wan H (2000) Determination of enantiomeric excess by capillary electrophoresis. Electrophoresis 21:1940–1962CrossRef
34.
Liu M, Da S, Feng Y, Li L (2005) Study on the preparation method and performance of a new β-cyclodextrin bonded silica stationary phase for liquid chromatography. Anal Chim Acta 533:89CrossRef
Metadaten
Titel
Construction of β-cyclodextrin linked glycidyl methacrylate polymers for stereoselective separation of chiral drug
verfasst von
Apparav Wale
Khudbudin Mulani
Supriya Deshpande
C. R. Rajan
Surendra Ponrathnam
Publikationsdatum
01.08.2021
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 8/2021
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-021-02634-7

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