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Microsystem Technologies

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11.12.2019 | Technical Paper

Design and optimization of MEMS based piezoelectric actuator for drug delivery systems

verfasst von: K. Srinivasa Rao, Md. Hamza, P. Ashok Kumar, K. Girija Sravani

Erschienen in: Microsystem Technologies | Ausgabe 5/2020

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Abstract

In this paper, piezoelectric principle based an actuator is design for a micropump, which is suitable for drug delivery systems. The natural frequency and stress analysis have been performed to determine the reliability of the device in terms of minimum safety factor. We have observed the uniform deflections of the actuators by varying the thicknesses of the piezoelectric layer of the actuator. The design of the actuators is considered in circular and rectangular geometry. The materials are selected appropriately such that the component is biocompatible and can be used in biomedical applications. Among the various considerations made on dimensions and geometry, it is observed that the circular piezoelectric actuator undergoes a high displacement of 2950 μm at an infinitesimal thickness of 0.1 μm. At minimum safety factor of one, the maximum stress and voltage the actuator can hold is 596 GPa and 8500 V respectively.

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Amirouche F, Zhou Y, Johnson T (2009) Current micropump technologies and their biomedical applications. Microsyst Technol. https://doi.org/10.1007/s00542-009-0804-7 CrossRef

Ardito R, Bertarelli E, Corigliano A, Gafforelli G (2013) On the application of piezolaminated composites to diaphragm micropumps. Compos Struct 99:231–240. https://doi.org/10.1016/j.compstruct.2012.11.041 CrossRef

Asadi Dereshgi H, Yildiz MZ (2019) Numerical study of novel MEMS-based valveless piezoelectric micropumps in the range of low voltages and frequencies. 2019 scientific meeting on electrical-electronics & biomedical engineering and computer science (EBBT). https://doi.org/10.1109/ebbt.2019.8741629

Cobo A, Sheybani R, Meng E (2015) MEMS: enabled drug delivery systems. Adv Healthc Mater 4(7):969–982. https://doi.org/10.1002/adhm.201400772 CrossRef

Cui Q, Liu C, Zha XF (2005) Simulation and optimization of a piezoelectric micropump for medical applications. Int J Adv Manuf Technol 36(5–6):516–524

Davis SS (2000) Drug deliver systems. Interdisc Sci Rev 25(3):175–183. https://doi.org/10.1179/030801800679206 CrossRef

Desai TA, Chu WH, Tu JK, Beattie GM, Hayek A, Ferrari M (1998) Microfabricated immunoisolating biocapsules. Biotechnol Bioeng 57(1):118–120. https://doi.org/10.1002/(sici)1097-0290(19980105)57:1%3c118:aid-bit14%3e3.0.co;2-g CrossRef

Dhananchezhiyana P, Hiremath Somashekhar S (2016) Optimization of multiple micro pumps to maximize the flow rate and minimize the flow pulsation. Procedia Technol 25(2016):1226–1233CrossRef

Farshchi Yazdi SAF, Corigliano A, Ardito R (2019) 3-D design and simulation of a piezoelectric micropump. Micromachines (Basel) 10(4):259. https://doi.org/10.3390/mi10040259 CrossRef

Gensler H, Sheybani R, Li P-Y, Lo R, Zhu S, Yong K-T, Roy I, Prasad PN, Masood R, Sinha UK, Meng E (2010) IEEE 23rd international conference on micro electro mechanical systems (MEMS). IEEE, New York, p 23

Gidde RR, Pawar PM, Ronge BP, Dhamgaye VP (2018) Design optimization of an electromagnetic actuation based valveless micropump for drug delivery application. Microsyst Technol. https://doi.org/10.1007/s00542-018-3987-y(01234 CrossRef

Gidde RR, Pawar PM, Dhamgaye VP (2019) Fully coupled modeling and design of a piezoelectric actuation based valveless micropump for drug delivery application. Microsyst Technol. https://doi.org/10.1007/s00542-019-04535-8 CrossRef

Haldkar RK, Gupta VK, Sheorey T (2017) Modeling and flow analysis of piezoelectric based micropump with various shapes of microneedle. J Mech Sci Technol 31(6):2933–2941CrossRef

Herrlich S, Spieth S, Messner S, Zengerle R (2012) Osmotic micropumps for drug delivery. Adv Drug Deliv Rev 64(14):1617–1627. https://doi.org/10.1016/j.addr.2012.02.003 CrossRef

Hollenstein E, Davis M, Damjanovic D, Setter N (2005) Piezoelectric properties of Li- and Ta-modified (Na_0.5K_0.5) NbO₃ ceramics. Appl Phys Lett 87(18):182905–182907. https://doi.org/10.1063/1.2123387 CrossRef

Hou W, Das B, Jiang Y, Qian S, Zheng X, Pi X, Yang J, Liu H, Zheng J, Zheng Z (2008) Simulation of the diaphragm properties of A PZT-based valveless micropump. ISBN: 978-1-4244-1907-4 CD: 978-1-4244-1908-1 INSPEC Accession Number: 9964067. https://doi.org/10.1109/nems.2008.4484369

Jiang Y, Wang H, Li S, Wen W (2014) Application of micro/nanoparticles in microfluidic sensors: a review. Sensors 14:6952–6964CrossRef

Junwu K, Zhigang Y, Taijiang P, Guangming C, Boda W (2005) Design and test of a high-performance piezoelectric micropump for drug delivery. Sens Actuators A 121(2005):156–161CrossRef

Karman S, Ibrahim F, Soin N (2007) A review of MEMS drug delivery in medical application. In: 3rd Kuala Lumpur international conference on biomedical engineering, pp 312–315

Lerner EI, Flashner-Barak M, Achthovem EV, Keegstra H, Smit R (2005) Delayed release formulations of 6-mercaptopurine. WO Patent 2005099666

Matsubara M, Yamaguchi T, Kikuta K, Hirano S (2005) Effect of Li substitution on the piezoelectric properties of potassium sodium niobate ceramics. Jpn J Appl Phys 44(8):6136–6142. https://doi.org/10.1143/JJAP.44.6136 CrossRef

McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJ, Whitesides GM (2000) Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21:27–40CrossRef

Mu YH, Hung NP, Ngoi KA (1999) Optimisation design of a piezoelectric micropump. Int J Adv Manuf Technol 15:573–576CrossRef

Prakash A, Markham A (1999) Oral delayed-release mesalazine: a review of its use in ulcerative colitis and Crohn’s disease. Drugs 57(3):383–408CrossRef

Revathi S, Padmapriya N, Padmanabhan R (2018) A design analysis of piezoelectric-polymer composite-based valveless micropump. Int J Model Simul. https://doi.org/10.1080/02286203.2018.1482521 CrossRef

Ringgaard E, Wurlitzer T (2005) Lead-free piezoceramics based on alkali niobates. J Eur Ceram Soc 25:2701CrossRef

Sharma SK, Ruggenenti P, Remuzzi G (2007) Managing hypertension in diabetic patients—focus on trandolapril/verapamil combination. Vasc Health Risk Manag 3(4):453–465

Shimamura K, Takeda H, Kohno T, Fakuda T (1996) Growth and characterization of lanthanum gallium silicate La₃Ga₅SiO₁₄ single crystals for piezoelectric applications. J Cryst Growth 163:388CrossRef

Sia SK, Whitesides GM (2003) Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 24(21):3563–3576. https://doi.org/10.1002/elps.200305584 CrossRef

Takenaka T, Nagata H (2005) Current status and prospects of lead-free piezoelectric ceramics. J Eur Ceram Soc 25:2693CrossRef

Tao SL, Desai TA (2003) Microfabricated drug delivery systems: from particles to pores. Adv Drug Deliv Rev 55:315CrossRef

Tariq N, Tayyaba S, Ashraf MW, Sarwar G, Wasim MF (2016) Comparative simulation of silicon, PDMS, PGA and PMMA actuator for piezoelectric micropump, INSPEC Accession Number: 16556469. https://doi.org/10.1109/icrai.2016.7791241

Tashiro S, Nagamatsu H, Nagata K (2002) Sinterability and piezoelectric properties of KNbO₃ ceramics after substituting Pb and Na for K. Jpn J Appl Phys 4(11B):7113–7118. https://doi.org/10.1143/JJAP.41.7113 CrossRef

Yi L, Moon K, Wong CP (2005) Electronics without lead. Science 308:1419CrossRef

Yildirim YA, Toprak A, Tigli O (2017) Piezoelectric membrane actuators for micropump applications using PVDF-TrFE. Microelectromech Syst 27(1):86–94CrossRef

Titel: Design and optimization of MEMS based piezoelectric actuator for drug delivery systems
verfasst von: K. Srinivasa Rao
Md. Hamza
P. Ashok Kumar
K. Girija Sravani
Publikationsdatum: 11.12.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Microsystem Technologies / Ausgabe 5/2020
Print ISSN: 0946-7076
Elektronische ISSN: 1432-1858
DOI: https://doi.org/10.1007/s00542-019-04712-9

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