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2022 | OriginalPaper | Buchkapitel

Development and Experimentation of a rTMS Device for Rats

verfasst von : P. R. S. Sanches, D. P. Silva, A. F. Müller, P. R. O. Thomé, A. C. Rossi, B. R. Tondin, R. Ströher, L. Santos, I. L. S. Torres

Erschienen in: XXVII Brazilian Congress on Biomedical Engineering

Verlag: Springer International Publishing

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Abstract

Neuropathic pain (NP) is related to the presence of hyperalgesia, allodynia and spontaneous pain, affecting 7–10% of the general population. Repetitive transcranial magnetic stimulation (rTMS) is being applied for NP relief especially in patients with refractory pain.

Objective: As NP response to existing treatments is often insufficient, we aimed to develop a magnetic stimulator and customized coils and evaluate rTMS treatment over the nociceptive response of rats submitted to a NP model.

Methods: The magnetic stimulator and the butterfly coils were developed in the Biomedical Engineering lab of Hospital de Clínicas de Porto Alegre. The device generated pulses with a 1 ms pulse width in a 1 Hz frequency. A total of 106 adult (60-days old) male Wistar rats were divided into 9 experimental groups: control (C), control plus sham rTMS (C + s.rTMS), control plus rTMS (C + rTMS), sham neuropathic pain (s.NP), sham neuropathic pain plus sham rTMS (s.NP + s.rTMS), sham neuropathic pain plus rTMS (s.NP + rTMS), neuropathic pain (NP), neuropathic pain + sham rTMS (NP + s.rTMS) and neuropathic pain plus rTMS (NP + rTMS). NP establishment was achieved 14 days after the surgery for chronic constriction injury (CCI) of the sciatic nerve, and rats were treated with daily 5-min sessions of rTMS for 8 consecutive days. Nociceptive behavior was assessed by von Frey and Hot Plate tests at baseline, after NP establishment and post-treatment.

Results: The measurement of magnetic field intensity 2.5 mm and 5.0 mm from the coil center on the 90º axis showed 160 mT and 125 mT respectively. rTMS treatment promoted a partial reversal of the mechanical allodynia and a total reversal of the thermal hyperalgesia induced by CCI.

Conclusions: We presume that low-frequency rTMS is a potential tool for NP treatment, possibly due to the modulation of plasticity and promotion of an analgesic effect.

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Titel: Development and Experimentation of a rTMS Device for Rats
verfasst von: P. R. S. Sanches
D. P. Silva
A. F. Müller
P. R. O. Thomé
A. C. Rossi
B. R. Tondin
R. Ströher
L. Santos
I. L. S. Torres
Verlag: Springer International Publishing
Buch: XXVII Brazilian Congress on Biomedical Engineering
Print ISBN: 978-3-030-70600-5

Electronic ISBN: 978-3-030-70601-2

Copyright-Jahr: 2022
DOI: https://doi.org/10.1007/978-3-030-70601-2_119

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