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International Journal of Computer Assisted Radiology and Surgery

Erschienen in:

28.05.2023 | Original Article

Development and validation of a radiofrequency ablation treatment planning system for vertebral metastases

verfasst von: Cari M. Whyne, Grace Underwood, Sean R. H. Davidson, Normand Robert, Christine Huang, Margarete K. Akens, Gabor Fichtinger, Albert J. M. Yee, Michael Hardisty

Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 12/2023

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Abstract

Purpose

Bone-targeted radiofrequency ablation (RFA) is widely used in the treatment of vertebral metastases. While radiation therapy utilizes established treatment planning systems (TPS) based on multimodal imaging to optimize treatment volumes, current RFA of vertebral metastases has been limited to qualitative image-based assessment of tumour location to direct probe selection and access. This study aimed to design, develop and evaluate a computational patient-specific RFA TPS for vertebral metastases.

Methods

A TPS was developed on the open-source 3D slicer platform, including procedural setup, dose calculation (based on finite element modelling), and analysis/visualization modules. Usability testing was carried out by 7 clinicians involved in the treatment of vertebral metastases on retrospective clinical imaging data using a simplified dose calculation engine. In vivo evaluation was performed in a preclinical porcine model (n = 6 vertebrae).

Results

Dose analysis was successfully performed, with generation and display of thermal dose volumes, thermal damage, dose volume histograms and isodose contours. Usability testing showed an overall positive response to the TPS as beneficial to safe and effective RFA. The in vivo porcine study showed good agreement between the manually segmented thermally damaged volumes vs. the damage volumes identified from the TPS (Dice Similarity Coefficient = 0.71 ± 0.03, Hausdorff distance = 1.2 ± 0.1 mm).

Conclusion

A TPS specifically dedicated to RFA in the bony spine could help account for tissue heterogeneities in both thermal and electrical properties. A TPS would enable visualization of damage volumes in 2D and 3D, assisting clinicians in decisions about potential safety and effectiveness prior to performing RFA in the metastatic spine.

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Roodman GD (2004) Mechanisms of bone metastasis. N Engl J Med 350:1655–1664. https://doi.org/10.1056/NEJMra030831CrossRefPubMed

Coleman RE (2006) Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 12:6243s-s6249. https://doi.org/10.1158/1078-0432.ccr-06-0931CrossRefPubMed

Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan S, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y (2012) International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 83:e597-605. https://doi.org/10.1016/j.ijrobp.2012.03.009CrossRefPubMed

Goldberg SN (2001) Radiofrequency tumor ablation: principles and techniques. Eur J Ultrasound 13:129–147. https://doi.org/10.1016/s0929-8266(01)00126-4CrossRefPubMed

Murali N, Turmezei T, Bhatti S, Patel P, Marshall T, Smith T (2021) What is the effectiveness of radiofrequency ablation in the management of patients with spinal metastases? a systematic review and meta-analysis. J Orthop Surg Res 16:659. https://doi.org/10.1186/s13018-021-02775-xCrossRefPubMedPubMedCentral

Prezzano KM, Prasad D, Hermann GM, Belal AN, Alberico RA (2019) Radiofrequency ablation and radiation therapy improve local control in spinal metastases compared to radiofrequency ablation alone. Am J Hosp Palliat Care 36:417–422. https://doi.org/10.1177/1049909118819460CrossRefPubMed

Villard C, Soler L, Gangi A (2005) Radiofrequency ablation of hepatic tumors: simulation, planning, and contribution of virtual reality and haptics. Comput Methods Biomech Biomed Engin 8:215–227. https://doi.org/10.1080/10255840500289988CrossRefPubMed

Chen CC, Miga MI, Galloway RL Jr (2009) Optimizing electrode placement using finite-element models in radiofrequency ablation treatment planning. IEEE Trans Biomed Eng 56:237–245. https://doi.org/10.1109/tbme.2008.2010383CrossRefPubMed

Rieder C, Schwier M, Weihusen A, Zidowitz S, Peitgen H-O (2009) Visualization of risk structures for interactive planning of image guided radiofrequency ablation of liver tumors. SPIE Med Imaging SPIE 726134:p1-9

10.

Yevich S, Chen S, Metwalli Z, Kuban J, Lee S, Habibollahi P, McCarthy CJ, Irwin D, Huang S, Sheth RA (2021) Radiofrequency ablation of spine metastases: a clinical and technical approach. Sem Musculoskelet Radiol 25:795–804. https://doi.org/10.1055/s-0041-1740351CrossRef

11.

Tomasian A, Gangi A, Wallace AN, Jennings JW (2018) Percutaneous thermal ablation of spinal metastases: recent advances and review. Am J Roentgenol 210:142–152. https://doi.org/10.2214/ajr.17.18205CrossRef

12.

Pezeshki PS, Woo J, Akens MK, Davies JE, Gofeld M, Whyne CM, Yee AJM (2014) Evaluation of a bipolar-cooled radiofrequency device for ablation of bone metastases: preclinical assessment in porcine vertebrae. Spine J 14:361–370. https://doi.org/10.1016/j.spinee.2013.08.041CrossRefPubMed

13.

https://www.medtronic.com/us-en/healthcare-professionals/products/spinal-orthopaedic/tumor-management/osteocool-ablation-system-rf.html

14.

Pinter C, Lasso A, Fichtinger G (2019) Polymorph segmentation representation for medical image computing. Comput Methods Progr Biomed 171:19–26. https://doi.org/10.1016/j.cmpb.2019.02.011CrossRef

15.

Liu Z, Lobo SM, Humphries S, Horkan C, Solazzo SA, Hines-Peralta AU, Lenkinski RE, Goldberg SN (2005) Radiofrequency tumor ablation: insight into improved efficacy using computer modeling. Am J Roentgenol 184:1347–1352. https://doi.org/10.2214/ajr.184.4.01841347CrossRef

16.

Huang H-W, Horng T-L (2015) Chapter 1 - Bioheat transfer and thermal heating for tumor treatment. In: Becker SM, Kuznetsov AV (eds) Heat transfer and fluid flow in biological processes. Academic Press, Boston, pp 1–42

17.

Haemmerich D (2010) Biophysics of radiofrequency ablation. Crit Rev Biomed Eng 38:53–63. https://doi.org/10.1615/critrevbiomedeng.v38.i1.50CrossRefPubMed

18.

Joe B (1991) GEOMPACK — a software package for the generation of meshes using geometric algorithms. Adv Eng Softw Workstn 13:325–31. https://doi.org/10.1016/0961-3552(91)90036-4CrossRef

19.

Fraass B, Doppke K, Hunt M, Kutcher G, Starkschall G, Stern R, Van Dyke J (1998) American association of physicists in medicine radiation therapy committee task group 53: quality assurance for clinical radiotherapy treatment planning. Med Phys 25:1773–1829. https://doi.org/10.1118/1.598373CrossRefPubMed

20.

Butz T, Warfield SK, Tuncali K, Silverman SG, Sonnenberg Ev, Jolesz FA, Kikinis R. Pre- and intra-operative planning and simulation of percutaneous tumor ablation. MICCAI 2000 Lecture notes in computer science V1935 pp 317–26

21.

Perez CA, Purdy JA, Harms W, Gerber R, Graham MV, Matthews JW, Bosch W, Drzymala R, Emami B, Fox S, Klein E, Lee HK, Michalski JM, Simpson JR (1995) Three-dimensional treatment planning and conformal radiation therapy: preliminary evaluation. Radiother Oncol 36:32–43. https://doi.org/10.1016/0167-8140(95)01566-yCrossRefPubMed

22.

Greenwood TJ, Wallace A, Friedman MV, Hillen TJ, Robinson CG, Jennings JW (2015) Combined ablation and radiation therapy of spinal metastases: a novel multimodality treatment approach. Pain Physician 18:573–581CrossRefPubMed

23.

Anchala PR, Irving WD, Hillen TJ, Friedman MV, Georgy BA, Coldwell DM, Tran ND, Vrionis FD, Brook A, Jennings JW (2014) Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: a multicenter retrospective study. Pain Physician 17:317–327PubMed

24.

https://itis.swiss/virtual-population/tissue-properties/database/low-frequency-conductivity/

25.

https://www.itis.ethz.ch/virtual-population/tissue-properties/database/heat-capacity/

26.

https://www.itis.ethz.ch/virtual-population/tissue-properties/database/density/

27.

https://www.itis.ethz.ch/virtual-population/tissue-properties/database/thermal-conductivity/

28.

Zhang H, Banovac F, Munuo S, Campos-Nanez E, Abeledo H, Cleary K (2007) Treatment planning and image guidance for radiofrequency ablation of liver tumors. SPIE, Medical ImagingCrossRef

29.

Pusceddu C, De Francesco D, Melis L, Ballicu N, Fancellu A (2021) The role of a navigational radiofrequency ablation device and concurrent vertebral augmentation for treatment of difficult-to-reach spinal metastases. Current Oncol 28:4004–4015. https://doi.org/10.3390/curroncol28050340CrossRef

30.

Jafari D (2019) Development and evaluation of a navigation workflow for radiofrequency ablation of spinal metastases. D Jafari. Master's thesis, University of Toronto Press

31.

Di Staso M, Zugaro L, Gravina GL, Bonfili P, Marampon F, Di Nicola L, Conchiglia A, Ventura L, Franzese P, Gallucci M, Masciocchi C, Tombolini V (2011) A feasibility study of percutaneous Radiofrequency Ablation followed by Radiotherapy in the management of painful osteolytic bone metastases. Eur Radiol 21:2004–2010. https://doi.org/10.1007/s00330-011-2133-3CrossRefPubMed

32.

Kotecha R, Schiro BJ, Sporrer J, Rubens M, Appel HR, Calienes KS, Boulanger B, Pujol MV, Suarez DT, Pena A, Kudryashev A, Mehta MP (2020) Radiation therapy alone versus radiation therapy plus radiofrequency ablation/vertebral augmentation for spine metastasis: study protocol for a randomized controlled trial. Trials 21:964. https://doi.org/10.1186/s13063-020-04895-xCrossRefPubMedPubMedCentral

33.

Madani K, Najafi A, Boticella A, Roux C, Tselikas L, Delpla A, Ahmar MA, de Baere T, Deschamps F (2022) Combined local treatments for vertebral metastases with limited epidural extension. Support Care Cancer 30:337–345. https://doi.org/10.1007/s00520-021-06443-yCrossRefPubMed

Titel: Development and validation of a radiofrequency ablation treatment planning system for vertebral metastases
verfasst von: Cari M. Whyne
Grace Underwood
Sean R. H. Davidson
Normand Robert
Christine Huang
Margarete K. Akens
Gabor Fichtinger
Albert J. M. Yee
Michael Hardisty
Publikationsdatum: 28.05.2023
Verlag: Springer International Publishing
Erschienen in: International Journal of Computer Assisted Radiology and Surgery / Ausgabe 12/2023
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
DOI: https://doi.org/10.1007/s11548-023-02952-9

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Abstract

Purpose

Methods

Results

Conclusion

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