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Topics in Catalysis
Erschienen in: Topics in Catalysis 9-12/2024

03.02.2024 | Original Paper

Development of Electrochemical Immunosensors for Early Diagnosis of Polycystic Ovary Syndrome (PCOS), and Their Potential Mobile Phone Application

verfasst von: Muhammad Ali Yousif Al-Janabi, Ramazan Bayat, Muhammed Bekmezci, Tiri Rima Nour Elhouda, Fatih Sen, Afsaneh Kaffash, Mehdi Baghayeri, Hassan Rokni, Fatemeh Karimi

Erschienen in: Topics in Catalysis | Ausgabe 9-12/2024

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Abstract

An effective way of monitoring the biomarker is with electrochemical sensor studies. In this work, it was formed using electrochemical deposition of high conductivity gold nanoparticles (AuNPs) and an amine-functional reduced graphene oxide (NH2-RGO) nanocomposite. This technique not only reduced HAuCl4 and graphene oxide in situ but also improved the electrocatalytic performance. XRD, SEM, and FTIR analytical methods confirmed the size and structure of the AuNPs/NH2-RGO nanoparticle. As a result of XRD analysis, AuNPs/NH2-RGO crystal structure was formed. In addition, antibodies (Ab) were immobilized on the modified electrode surface using a self-assembled monolayer. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods were used to evaluate the interaction of Ab with antigen. SHBG detection had a dynamic linear range of 0.6–12 nmol/L and a limit of detection (LOD) of 0.0043 µM in enhanced sensor applications. The AuNPs/NH2-RGO based sensor has the potential to be a valuable tool in clinical diagnostic applications in the future.
Vorheriger Artikel Nanomodified Geopolymers with Copper Ferrites for Methylene Blue Degradation
Nächster Artikel Immobilization of Xylanase into Zeolitic Imidazolate Framework-67 (ZIF-67) and Manganese-Doped ZIF-67 (Mn/ZIF-67): A Comparison Study

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Metadaten
Titel
Development of Electrochemical Immunosensors for Early Diagnosis of Polycystic Ovary Syndrome (PCOS), and Their Potential Mobile Phone Application
verfasst von
Muhammad Ali Yousif Al-Janabi
Ramazan Bayat
Muhammed Bekmezci
Tiri Rima Nour Elhouda
Fatih Sen
Afsaneh Kaffash
Mehdi Baghayeri
Hassan Rokni
Fatemeh Karimi
Publikationsdatum
03.02.2024
Verlag
Springer US
Erschienen in
Topics in Catalysis / Ausgabe 9-12/2024
Print ISSN: 1022-5528
Elektronische ISSN: 1572-9028
DOI
https://doi.org/10.1007/s11244-023-01899-0

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