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2015 | OriginalPaper | Buchkapitel

5. Die eukaryotische Zelle und Modellorganismen

verfasst von : Jochen Graw

Erschienen in: Genetik

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Die Zelle als ein Grundbaustein aller Organismen wurde bereits 1665 durch Robert Hooke (1635–1703) bei seinen Untersuchungen an Pflanzen beschrieben; er führte auch die Bezeichnung cell ein. Diese Beobachtungen waren mithilfe eines einfachen Mikroskops gemacht worden (Abb. 5.1). Obwohl in der Folge Nehemiah Grew (1614–1712) und Antoni van Leeuwenhoek (1632–1723) die mikroskopische Feinstruktur von Tieren und Pflanzen in vielen Details studierten, setzte das mangelhafte Auflösungsvermögen der frühen Mikroskope solchen Studien enge Grenzen. Erst die Verbesserungen der optischen Qualität, insbesondere durch die Korrektur sphärischer und chromatischer Aberrationen, erlaubten es, Feinheiten im Bau tierischer Gewebe zu erkennen.

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Literatur
Zurück zum Zitat Adams MD, Celniker SE, Holt RA et al. (2000) The genome sequence of Drosophila melanogaster. Science 287:2185–2195CrossRefPubMed Adams MD, Celniker SE, Holt RA et al. (2000) The genome sequence of Drosophila melanogaster. Science 287:2185–2195CrossRefPubMed
Zurück zum Zitat Ahn SH, Diaz RL, Grunstein M et al. (2006) Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at Serine 10. Mol Cell 24:211–220CrossRefPubMed Ahn SH, Diaz RL, Grunstein M et al. (2006) Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at Serine 10. Mol Cell 24:211–220CrossRefPubMed
Zurück zum Zitat Ankeny RA (2001) The natural history of Caenorhabditis elegans research. Nat Rev Genet 2:474–479CrossRefPubMed Ankeny RA (2001) The natural history of Caenorhabditis elegans research. Nat Rev Genet 2:474–479CrossRefPubMed
Zurück zum Zitat Argmann CA, Chambon P, Auwerx J (2005) Mouse phenogenomics: the fast track to »systems metabolism«. Cell Metab 2:349–360CrossRefPubMed Argmann CA, Chambon P, Auwerx J (2005) Mouse phenogenomics: the fast track to »systems metabolism«. Cell Metab 2:349–360CrossRefPubMed
Zurück zum Zitat Barr ML, Bertram EG (1949) A morphological distinction between neurons of the male and female, and the behaviour of the nucleolar satellites during accelerated nucleoprotein synthesis. Nature 163:676–677CrossRefPubMed Barr ML, Bertram EG (1949) A morphological distinction between neurons of the male and female, and the behaviour of the nucleolar satellites during accelerated nucleoprotein synthesis. Nature 163:676–677CrossRefPubMed
Zurück zum Zitat de Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159–169CrossRefPubMed de Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14:159–169CrossRefPubMed
Zurück zum Zitat Burger G, Gray MW, Lang BF (2003) Mitochondrial genomes: anything goes. Trends Genet 19:709–716CrossRefPubMed Burger G, Gray MW, Lang BF (2003) Mitochondrial genomes: anything goes. Trends Genet 19:709–716CrossRefPubMed
Zurück zum Zitat van Buskirk EK, Decker PV, Chen M (2012) Photobodies in light signaling. Plant Physiol 158:52–60CrossRefPubMed van Buskirk EK, Decker PV, Chen M (2012) Photobodies in light signaling. Plant Physiol 158:52–60CrossRefPubMed
Zurück zum Zitat de Celis JF (2003) Pattern formation in the Drosophila wing: the development of the veins. BioEssays 25:443–451CrossRefPubMed de Celis JF (2003) Pattern formation in the Drosophila wing: the development of the veins. BioEssays 25:443–451CrossRefPubMed
Zurück zum Zitat Christensen K, Johnson TE, Vaupel JW (2006) The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet 7: 436–448CrossRefPubMedPubMedCentral Christensen K, Johnson TE, Vaupel JW (2006) The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet 7: 436–448CrossRefPubMedPubMedCentral
Zurück zum Zitat Cremer T, Cremer C (2001) Chromosome territorries, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet 2:292–301CrossRefPubMed Cremer T, Cremer C (2001) Chromosome territorries, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet 2:292–301CrossRefPubMed
Zurück zum Zitat Doebley JF, Gaut BS, Smith BD (2006) The molecular genetics of crop domestication. Cell 127:1309–1321CrossRefPubMed Doebley JF, Gaut BS, Smith BD (2006) The molecular genetics of crop domestication. Cell 127:1309–1321CrossRefPubMed
Zurück zum Zitat Flemming W (1882) Zellsubstanz, Kern und Zelltheilung. F. C. W. Vogel, Leipzig Folle GA (2008) Nuclear architecture, chromosome domains and genetic damage. Mutat Res 658:172–183 Flemming W (1882) Zellsubstanz, Kern und Zelltheilung. F. C. W. Vogel, Leipzig Folle GA (2008) Nuclear architecture, chromosome domains and genetic damage. Mutat Res 658:172–183
Zurück zum Zitat Frankel S, Rogina B (2012) Indy mutants: live long and prosper. Front Genet 3:1–3CrossRef Frankel S, Rogina B (2012) Indy mutants: live long and prosper. Front Genet 3:1–3CrossRef
Zurück zum Zitat Friedman DB, Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertiliy. Genetics 118:75–86PubMedPubMedCentral Friedman DB, Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertiliy. Genetics 118:75–86PubMedPubMedCentral
Zurück zum Zitat Furutani-Seiki M, Wittbrodt J (2004) Medaka and zebrafish, an evolutionary twin study. Mech Dev 121:629–637CrossRefPubMed Furutani-Seiki M, Wittbrodt J (2004) Medaka and zebrafish, an evolutionary twin study. Mech Dev 121:629–637CrossRefPubMed
Zurück zum Zitat Galluzzi L, Kepp O, Trojel-Hansen C et al. (2012) Mitochondrial control of cellular life, stress, and death. Circ Res 111:1198–1207CrossRefPubMed Galluzzi L, Kepp O, Trojel-Hansen C et al. (2012) Mitochondrial control of cellular life, stress, and death. Circ Res 111:1198–1207CrossRefPubMed
Zurück zum Zitat Gaszner M, Felsenfeld G (2006) Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet 7:703–713CrossRefPubMed Gaszner M, Felsenfeld G (2006) Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet 7:703–713CrossRefPubMed
Zurück zum Zitat Goffeau A, Barrell BG, Bussey H et al. (1996) Life with 6000 genes. Science 274:646–563CrossRef Goffeau A, Barrell BG, Bussey H et al. (1996) Life with 6000 genes. Science 274:646–563CrossRef
Zurück zum Zitat Gordon JW, Scangos GA, Plotkin DJ et al. (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77:7380–7384CrossRefPubMedPubMedCentral Gordon JW, Scangos GA, Plotkin DJ et al. (1980) Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77:7380–7384CrossRefPubMedPubMedCentral
Zurück zum Zitat Green EL (Hrsg) (1966) Biology of the Laboratory Mouse, 2. Aufl. McGraw-Hill, New York Green EL (Hrsg) (1966) Biology of the Laboratory Mouse, 2. Aufl. McGraw-Hill, New York
Zurück zum Zitat Guénet JL (2011) Animal models of human genetic diseases: do they need to be faithful to be useful? Mol Genet Genomics 286:1–20CrossRefPubMed Guénet JL (2011) Animal models of human genetic diseases: do they need to be faithful to be useful? Mol Genet Genomics 286:1–20CrossRefPubMed
Zurück zum Zitat Haffter P, Granato M, Brand M et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123:1–36PubMed Haffter P, Granato M, Brand M et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123:1–36PubMed
Zurück zum Zitat Handwerger KE, Gall JG (2006) Subnuclear organelles: new insights into form and function. Trends Cell Biol 16:19–26CrossRefPubMed Handwerger KE, Gall JG (2006) Subnuclear organelles: new insights into form and function. Trends Cell Biol 16:19–26CrossRefPubMed
Zurück zum Zitat Haskins FA, Tissieres A, Mitchell HK et al. (1953) Cytochromes and the succinic acid oxidase system of poky strains of Neurospora. J Biol Chem 200: 819–826PubMed Haskins FA, Tissieres A, Mitchell HK et al. (1953) Cytochromes and the succinic acid oxidase system of poky strains of Neurospora. J Biol Chem 200: 819–826PubMed
Zurück zum Zitat Holt IJ, Harding AE, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717–719CrossRefPubMed Holt IJ, Harding AE, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 331: 717–719CrossRefPubMed
Zurück zum Zitat Howard A, Pelc SR (1953) Synthesis of deoxyribonucleic acid in normal and irradiated cells and its relation to chromosome breakage. In: Symposium on chromosome breakage. Heredity 6 (Suppl):261–273 Howard A, Pelc SR (1953) Synthesis of deoxyribonucleic acid in normal and irradiated cells and its relation to chromosome breakage. In: Symposium on chromosome breakage. Heredity 6 (Suppl):261–273
Zurück zum Zitat Howe K, Clark MD, Torroja CF et al. (2013) The zebrafisch reference genome sequence and its relationship to the human genome. Nature 496: 498–503CrossRefPubMedPubMedCentral Howe K, Clark MD, Torroja CF et al. (2013) The zebrafisch reference genome sequence and its relationship to the human genome. Nature 496: 498–503CrossRefPubMedPubMedCentral
Zurück zum Zitat International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409:860–921CrossRef International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409:860–921CrossRef
Zurück zum Zitat Johnston DS (2002) The art and design of genetic screens: Drosophila melanogaster. Nat Rev Genet 3:176–188CrossRef Johnston DS (2002) The art and design of genetic screens: Drosophila melanogaster. Nat Rev Genet 3:176–188CrossRef
Zurück zum Zitat Jorgensen EM, Mango SE (2002) The art and design of genetic screens: Caenorhabditis elegans. Nat Rev Genet 3:356–369CrossRefPubMed Jorgensen EM, Mango SE (2002) The art and design of genetic screens: Caenorhabditis elegans. Nat Rev Genet 3:356–369CrossRefPubMed
Zurück zum Zitat Kalueff AV, Stewart AM, Kyzar EJ et al. (2012) Time to recognize zebrafish ›affective‹ behavior. Behaviour 149:1019–1036CrossRef Kalueff AV, Stewart AM, Kyzar EJ et al. (2012) Time to recognize zebrafish ›affective‹ behavior. Behaviour 149:1019–1036CrossRef
Zurück zum Zitat Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257CrossRefPubMedPubMedCentral Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257CrossRefPubMedPubMedCentral
Zurück zum Zitat Kiefel BR, Gilson PR, Beech PL (2006) Cell biology of mitochondrial dynamics. Intern Rev Cytology 254:151–213CrossRef Kiefel BR, Gilson PR, Beech PL (2006) Cell biology of mitochondrial dynamics. Intern Rev Cytology 254:151–213CrossRef
Zurück zum Zitat Kihlman B, Eriksson T, Odmark G (1967) Studies on the effects of phleomycin on chromosome structure and nucleic acid synthesis in Vicia faba. Mutat Res 4:783–790CrossRefPubMed Kihlman B, Eriksson T, Odmark G (1967) Studies on the effects of phleomycin on chromosome structure and nucleic acid synthesis in Vicia faba. Mutat Res 4:783–790CrossRefPubMed
Zurück zum Zitat Kück U (Hrsg) (2005) Praktikum der Molekulargenetik. Springer, BerlinCrossRef Kück U (Hrsg) (2005) Praktikum der Molekulargenetik. Springer, BerlinCrossRef
Zurück zum Zitat Kuro-o M, Matsumura Y, Aizawa H et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45–51CrossRefPubMed Kuro-o M, Matsumura Y, Aizawa H et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45–51CrossRefPubMed
Zurück zum Zitat Kurosu H, Kuro-o M (2009) The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol 299:72–78CrossRefPubMed Kurosu H, Kuro-o M (2009) The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol 299:72–78CrossRefPubMed
Zurück zum Zitat Kyriakouli DS, Boesch P, Taylor RW et al. (2008) Progress and prospects: gene therapy for mitochondrial DNA disease. Gene Therapy 15:1017–1023CrossRefPubMed Kyriakouli DS, Boesch P, Taylor RW et al. (2008) Progress and prospects: gene therapy for mitochondrial DNA disease. Gene Therapy 15:1017–1023CrossRefPubMed
Zurück zum Zitat Labrador M, Corces VG (2002) Setting the boundaries of chromatin domains and nuclear organization. Cell 111:151–154CrossRefPubMed Labrador M, Corces VG (2002) Setting the boundaries of chromatin domains and nuclear organization. Cell 111:151–154CrossRefPubMed
Zurück zum Zitat Laibach F (1907) Zur Frage nach der Individualität der Chromosomen im Pflanzenreich. Beih Bot Cbl 22, Abt. I:191−210 Laibach F (1907) Zur Frage nach der Individualität der Chromosomen im Pflanzenreich. Beih Bot Cbl 22, Abt. I:191−210
Zurück zum Zitat Li P, Schulze EN, Tong C et al. (2011) Rat embryonic stem cell derivation and propagation. In: Pease S, Saunders TL (Hrsg) Advanced Protocols for Animal Transgenesis. Springer, Berlin, 457–475 Li P, Schulze EN, Tong C et al. (2011) Rat embryonic stem cell derivation and propagation. In: Pease S, Saunders TL (Hrsg) Advanced Protocols for Animal Transgenesis. Springer, Berlin, 457–475
Zurück zum Zitat Lieschke GJ, Currie PD (2007) Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8:353–367CrossRefPubMed Lieschke GJ, Currie PD (2007) Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8:353–367CrossRefPubMed
Zurück zum Zitat Lindegren CC, Lindegren G (1949) Unusual gene-controlled combinations of carbohydrate fermentations in yeast hybrids. Proc Natl Acad Sci USA 35:23–27CrossRefPubMedPubMedCentral Lindegren CC, Lindegren G (1949) Unusual gene-controlled combinations of carbohydrate fermentations in yeast hybrids. Proc Natl Acad Sci USA 35:23–27CrossRefPubMedPubMedCentral
Zurück zum Zitat Lundberg AS, Weinberg RA (1999) Control of the cell cycle and apoptosis. Eur J Cancer 35:1886–1894CrossRefPubMed Lundberg AS, Weinberg RA (1999) Control of the cell cycle and apoptosis. Eur J Cancer 35:1886–1894CrossRefPubMed
Zurück zum Zitat Lyon MF (1961) Gene action in the X-chromosome of the mouse (Mus musculus L). Nature 190:372–373CrossRefPubMed Lyon MF (1961) Gene action in the X-chromosome of the mouse (Mus musculus L). Nature 190:372–373CrossRefPubMed
Zurück zum Zitat Marston AL, Amon A (2004) Meiosis: cell-cycle controls shuffle and deal. Nat Rev Mol Cell Biol 5:983–997CrossRefPubMed Marston AL, Amon A (2004) Meiosis: cell-cycle controls shuffle and deal. Nat Rev Mol Cell Biol 5:983–997CrossRefPubMed
Zurück zum Zitat Mazia D (1961) Mitosis and the physiology of cell division. In: Brachet J, Mirskey AE (Hrsg) The Cell, Bd. 3. Academic Press, New York Mazia D (1961) Mitosis and the physiology of cell division. In: Brachet J, Mirskey AE (Hrsg) The Cell, Bd. 3. Academic Press, New York
Zurück zum Zitat Mereschkowsky C (1905) Über Natur und Ursprung der Chromatophoren im Pflanzenreiche. Biol Centralbl 25:593–604 Mereschkowsky C (1905) Über Natur und Ursprung der Chromatophoren im Pflanzenreiche. Biol Centralbl 25:593–604
Zurück zum Zitat Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382:536–539CrossRefPubMed Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382:536–539CrossRefPubMed
Zurück zum Zitat Müller WA, Hassel M (2012) Entwicklungsbiologie und Reproduktionsbiologie des Menschen und bedeutender Modellorganismen, 5. Aufl. Springer Spektrum, HeidelbergCrossRef Müller WA, Hassel M (2012) Entwicklungsbiologie und Reproduktionsbiologie des Menschen und bedeutender Modellorganismen, 5. Aufl. Springer Spektrum, HeidelbergCrossRef
Zurück zum Zitat Munk K (2000) Grundstudium Biologie: Biochemie, Zellbiologie, Ökologie, Evolution. Spektrum Akademischer Verlag, Heidelberg Munk K (2000) Grundstudium Biologie: Biochemie, Zellbiologie, Ökologie, Evolution. Spektrum Akademischer Verlag, Heidelberg
Zurück zum Zitat Neretti N, Wang PY, Brodsky AS et al. (2009) Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage. Proc Natl Acad Sci USA 106:2277–2282CrossRefPubMedPubMedCentral Neretti N, Wang PY, Brodsky AS et al. (2009) Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage. Proc Natl Acad Sci USA 106:2277–2282CrossRefPubMedPubMedCentral
Zurück zum Zitat Norton WHJ, Bally-Cuif L (2012) Unravelling the proximate causes of the aggression-boldness behavioural syndrome in zebrafish. Behaviour 149:1063–1079CrossRef Norton WHJ, Bally-Cuif L (2012) Unravelling the proximate causes of the aggression-boldness behavioural syndrome in zebrafish. Behaviour 149:1063–1079CrossRef
Zurück zum Zitat Nowrousian M (2007) Neurospora crassa als Modellorganismus im »postgenomischen « Zeitalter. BIOspektrum 13:709–712 Nowrousian M (2007) Neurospora crassa als Modellorganismus im »postgenomischen « Zeitalter. BIOspektrum 13:709–712
Zurück zum Zitat Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795–801CrossRefPubMed Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795–801CrossRefPubMed
Zurück zum Zitat Ouyang L, Shi Z, Zhao S et al. (2012) Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 45:487–98CrossRefPubMed Ouyang L, Shi Z, Zhao S et al. (2012) Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 45:487–98CrossRefPubMed
Zurück zum Zitat Paaby AB, Schmidt PS (2008) Functional significance of allelic variation at methuselah, an aging gene in Drosophila. PLoS One 3:e198–7CrossRef Paaby AB, Schmidt PS (2008) Functional significance of allelic variation at methuselah, an aging gene in Drosophila. PLoS One 3:e198–7CrossRef
Zurück zum Zitat Page DR, Grossniklaus U (2002) The art and design of genetic screens: Arabidopsis thaliana. Nat Rev Genet 3:124–136CrossRefPubMed Page DR, Grossniklaus U (2002) The art and design of genetic screens: Arabidopsis thaliana. Nat Rev Genet 3:124–136CrossRefPubMed
Zurück zum Zitat Paigen K (2003a) One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980). Genetics 163:1–7PubMedPubMedCentral Paigen K (2003a) One hundred years of mouse genetics: an intellectual history. I. The classical period (1902-1980). Genetics 163:1–7PubMedPubMedCentral
Zurück zum Zitat Paigen K (2003b) One hundred years of mouse genetics: an intellectual history. II. The molecular revolution (1981-2002). Genetics 163:1227–1235PubMedPubMedCentral Paigen K (2003b) One hundred years of mouse genetics: an intellectual history. II. The molecular revolution (1981-2002). Genetics 163:1227–1235PubMedPubMedCentral
Zurück zum Zitat Peters LL, Robledo RF, Bult CJ et al. (2007) The mouse as a model for human biology: a resource guide for complex trait analysis. Nat Rev Genet 8: 58–69CrossRefPubMed Peters LL, Robledo RF, Bult CJ et al. (2007) The mouse as a model for human biology: a resource guide for complex trait analysis. Nat Rev Genet 8: 58–69CrossRefPubMed
Zurück zum Zitat Raab JR, Chiu J, Zhu J et al. (2012) Human tRNA genes function as chromatin insulators. EMBO J 31:330–350CrossRefPubMed Raab JR, Chiu J, Zhu J et al. (2012) Human tRNA genes function as chromatin insulators. EMBO J 31:330–350CrossRefPubMed
Zurück zum Zitat Raju NB (2009) Neurospora as a model fungus for studies in cytogenetics and sexual biology at Stanford. J Biosci 34:139–159CrossRefPubMed Raju NB (2009) Neurospora as a model fungus for studies in cytogenetics and sexual biology at Stanford. J Biosci 34:139–159CrossRefPubMed
Zurück zum Zitat Raven JA, Allen JF (2003) Genomics and chloroplast evolution: what did cyanobacteria do for plants? Genome Biol 4:20–9CrossRef Raven JA, Allen JF (2003) Genomics and chloroplast evolution: what did cyanobacteria do for plants? Genome Biol 4:20–9CrossRef
Zurück zum Zitat Rosenthal N, Ashburner M (2002) Taking stock of our models: the function and future of stock centres. Nat Rev Genet 3:711–717CrossRefPubMed Rosenthal N, Ashburner M (2002) Taking stock of our models: the function and future of stock centres. Nat Rev Genet 3:711–717CrossRefPubMed
Zurück zum Zitat Santos RX, Correia SC, Cardoso S et al. (2011) Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease. J Neurochem 117:927–936CrossRefPubMed Santos RX, Correia SC, Cardoso S et al. (2011) Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease. J Neurochem 117:927–936CrossRefPubMed
Zurück zum Zitat Schnittger A, Hülskamp M (2002) Trichome morphogenesis: a cell-cycle perspective. Phil Trans R Soc Lond B 357:823–826CrossRef Schnittger A, Hülskamp M (2002) Trichome morphogenesis: a cell-cycle perspective. Phil Trans R Soc Lond B 357:823–826CrossRef
Zurück zum Zitat Schwarz-Sommer Z, Davis B, Hudson A (2003) An everlasting pioneer: the story of Antirrhinum research. Nat Rev Genet 4:655–664CrossRef Schwarz-Sommer Z, Davis B, Hudson A (2003) An everlasting pioneer: the story of Antirrhinum research. Nat Rev Genet 4:655–664CrossRef
Zurück zum Zitat Sommerville C, Koornneef M (2002) A fortunate choice: the history of Arabidopsis as a model plant. Nat Rev Genet 3:883–889CrossRef Sommerville C, Koornneef M (2002) A fortunate choice: the history of Arabidopsis as a model plant. Nat Rev Genet 3:883–889CrossRef
Zurück zum Zitat Streisinger G, Walker C, Dower N et al. (1981) Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature 291:293–296CrossRefPubMed Streisinger G, Walker C, Dower N et al. (1981) Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature 291:293–296CrossRefPubMed
Zurück zum Zitat Tesson L, Cozzi J, Ménoret S et al. (2005) Transgenic modifications of the rat genome. Transgenic Res 14:531–546CrossRefPubMed Tesson L, Cozzi J, Ménoret S et al. (2005) Transgenic modifications of the rat genome. Transgenic Res 14:531–546CrossRefPubMed
Zurück zum Zitat The Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796–815 The Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796–815
Zurück zum Zitat The C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigative biology. Science 282:2012–2018 The C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigative biology. Science 282:2012–2018
Zurück zum Zitat The Tomato Genome Consortium (2012) The tomato genome sequence provides insights into the fleshy fruit evolution. Nature 485:635–641CrossRef The Tomato Genome Consortium (2012) The tomato genome sequence provides insights into the fleshy fruit evolution. Nature 485:635–641CrossRef
Zurück zum Zitat Toivonen JM, Gems D, Partridge L (2009) Longevity of Indy mutant Drosophila not attributable to Indy mutation. Proc Natl Acad Sci USA 106:E53 Toivonen JM, Gems D, Partridge L (2009) Longevity of Indy mutant Drosophila not attributable to Indy mutation. Proc Natl Acad Sci USA 106:E53
Zurück zum Zitat Vanden Berghe T, Linkermann, Jouan-Lanhouet S et al. (2014) Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 15:135–147CrossRefPubMed Vanden Berghe T, Linkermann, Jouan-Lanhouet S et al. (2014) Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol 15:135–147CrossRefPubMed
Zurück zum Zitat Venter JC, Adams MD, Myers EW et al. (2001) The sequence of the human genome. Science 291:1304–1351CrossRefPubMed Venter JC, Adams MD, Myers EW et al. (2001) The sequence of the human genome. Science 291:1304–1351CrossRefPubMed
Zurück zum Zitat de Veylder L, Beeckman, Beemster GTS et al. (2002) Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-Dpa transcription factor. EMBO J 21:1360–1368CrossRefPubMedPubMedCentral de Veylder L, Beeckman, Beemster GTS et al. (2002) Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-Dpa transcription factor. EMBO J 21:1360–1368CrossRefPubMedPubMedCentral
Zurück zum Zitat Wagner TE, Hoppe PC, Jollick JD et al. (1981) Microinjection of a rabbit β-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci USA 78:6376–6380CrossRefPubMedPubMedCentral Wagner TE, Hoppe PC, Jollick JD et al. (1981) Microinjection of a rabbit β-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci USA 78:6376–6380CrossRefPubMedPubMedCentral
Zurück zum Zitat Wallace DC, Singh G, Lott MT et al. (1988) Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 242:1427–1430CrossRefPubMed Wallace DC, Singh G, Lott MT et al. (1988) Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. Science 242:1427–1430CrossRefPubMed
Zurück zum Zitat Wang PY, Neretti N, Whitaker R et al. (2009) Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci USA 106:9262–9267CrossRefPubMedPubMedCentral Wang PY, Neretti N, Whitaker R et al. (2009) Long-lived Indy and calorie restriction interact to extend life span. Proc Natl Acad Sci USA 106:9262–9267CrossRefPubMedPubMedCentral
Zurück zum Zitat Yu F, Fu A, Aluru M et al. (2007) Variegation mutants and mechanisms of chloroplast biogenesis. Plant Cell Environ 30:350–365CrossRefPubMed Yu F, Fu A, Aluru M et al. (2007) Variegation mutants and mechanisms of chloroplast biogenesis. Plant Cell Environ 30:350–365CrossRefPubMed
Metadaten
Titel
Die eukaryotische Zelle und Modellorganismen
verfasst von
Jochen Graw
Copyright-Jahr
2015
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-44817-5_5

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