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Journal of Nanoparticle Research

Erschienen in:

01.10.2011 | Research Paper

Differential toxicity of amorphous silica nanoparticles toward phagocytic and epithelial cells

verfasst von: Alexander Malugin, Heather Herd, Hamidreza Ghandehari

Erschienen in: Journal of Nanoparticle Research | Ausgabe 10/2011

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Abstract

The objective of this study was to evaluate the influence of size and surface functionality of amorphous silica nanoparticles (SNPs) on their interaction with cultured cells. The intracellular uptake, phagocytic activity, and possible mechanisms of toxicity induced by SNPs were studied on murine alveolar macrophages and two epithelial cancer cell lines. It was found that phagocytic cells are more susceptible to amorphous SNPs than epithelial cells. SNPs with functionalized surfaces were capable to induce the formation of apoptotic cells to a higher extent than plain particles. Plain SNPs induced plasma membrane damage in phagocytic cells to a higher extent and caused cell death in a shorter period of time than surface-functionalized SNPs. The prevalence of necrotic mode of cell death was observed after treatment with plain SNPs. In the range studied surface functionality played an important role in SNPs toxicity.

Vorheriger Artikel Plasma kinetics and biodistribution of water-soluble CdTe quantum dots in mice: a comparison between Cd and Te

Nächster Artikel Fabrication and characterization of Cu–CdSe–Cu nanowire heterojunctions

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Titel: Differential toxicity of amorphous silica nanoparticles toward phagocytic and epithelial cells
verfasst von: Alexander Malugin
Heather Herd
Hamidreza Ghandehari
Publikationsdatum: 01.10.2011
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 10/2011
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-011-0524-7

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