2012 | OriginalPaper | Buchkapitel
Discovery of Complex Genomic Rearrangements in Cancer Using High-Throughput Sequencing
verfasst von : Andrew McPherson, Chunxiao Wu, Alexander Wyatt, Sohrab Shah, Colin Collins, S. Cenk Sahinalp
Erschienen in: Research in Computational Molecular Biology
Verlag: Springer Berlin Heidelberg
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
High-throughput sequencing now allows researchers to identify patterns of rearrangement in tumour genomes, and has led to the discovery of Complex Genomic Rearrangements (CGRs) as a new cytogenetic feature of some cancers. Closed chain breakage and rejoining (CCBR), a generalization of reciprocal translocation, was recently identified in prostate cancer [4]. CCBRs involve the balanced rearrangement of some
n
loci, and thus have the potential to fuse or interrupt up to
n
genes. In addition, dispersed throughout some breast cancer genomes are ‘genomic shards’, small fragments of DNA originating from elsewhere in the genome and inserted at the breakpoints of larger scale rearrangements.