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New Generation Computing

Erschienen in:

10.05.2022

DNA Concentration Regulator That can be Driven for a Long Time

verfasst von: Takashi Nakakuki, Keiji Murayama, Hiroyuki Asanuma

Erschienen in: New Generation Computing | Ausgabe 2/2022

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Abstract

A molecular robot is an autonomous micro/nano machine that mounts a molecular controller connecting the sensor and actuator systems. A major control problem of a molecular robot is to maintain the actuator operation at the desired level. This requires a regulator that adjusts the concentration of a specific DNA strand of a system to the desired level to be appropriately implemented on a chemical reaction system made of molecular interactions among DNA strands. However, although there are several research results on DNA concentration regulators, there is a major problem: the regulators normally work only within a limited period because of the finiteness problem of gate and fuel strands. The operating time of the controller is an important control performance index and is a prerequisite for its practical applications. In this study, the design of a renewable DNA concentration regulator simplified to an experimentally feasible level is proposed, inspired by the previously reported azobenzene-based photo-reaction method used for a renewable PID controller. It is shown that the methodology that timely switches the operation between “regulator mode” and “concentration recovery mode” by light irradiation can serve as a solution for the long-time operation of the DNA concentration regulator.

Vorheriger Artikel Chemical Reaction Regular Grammars

Nächster Artikel Toggling Between Two Limit Cycles in a Molecular Ecosystem

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Titel: DNA Concentration Regulator That can be Driven for a Long Time
verfasst von: Takashi Nakakuki
Keiji Murayama
Hiroyuki Asanuma
Publikationsdatum: 10.05.2022
Verlag: Ohmsha
Erschienen in: New Generation Computing / Ausgabe 2/2022
Print ISSN: 0288-3635
Elektronische ISSN: 1882-7055
DOI: https://doi.org/10.1007/s00354-022-00173-3

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