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2017 | OriginalPaper | Buchkapitel

7. DNA-Seq Error Correction Based on Substring Indices

verfasst von : David Weese, Marcel H. Schulz, Hugues Richard

Erschienen in: Algorithms for Next-Generation Sequencing Data

Verlag: Springer International Publishing

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Abstract

Next-Generation Sequencing (NGS) has revolutionized genomics. NGS technologies produce millions of sequencing reads of a few hundred bases in length. In the following, we focus on NGS reads produced by genome sequencing of a clonal cell population, which has important applications like the de novo genome assembly of previously unknown genomes, for example, recently mutated parasites (Mellmann et al., PLoS ONE 6(7):e22751, 2011) or newly sequenced genomes (Locke et al., Nature 469:529–533, 2011).

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Fußnoten
1
Assuming a constant-sized alphabet.
 
2
The artificial $ characters must be appended to each sequence to let all suffixes end in leaves.
 
3
The Hamming distance between two sequences of same length is the number of positions at which the letters are different.
 
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Metadaten
Titel
DNA-Seq Error Correction Based on Substring Indices
verfasst von
David Weese
Marcel H. Schulz
Hugues Richard
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-59826-0_7

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