Drug release study by a novel thermo sensitive nanogel based on salep modified graphene oxide

To develop more effective drug delivery systems, a novel thermo sensitive nanogels (TNGs) were prepared by crosslinking of NIPAM graft copolymerization onto salep modified graphene oxide (SMGO). The sizes of as-synthesized TNGs were about 93 nm. It was found that the concentration of GO, surfactant, and polymerization agent were strongly effected on the average size of TNGs. Besides, obtained TNGs display thermo-induced transmittance due to thermo-responsive PNIPAM contained in synthesized TNGs. Moreover, the TNGs presented high drug loading capacity and excellent drug release at higher temperate, without any burst release. It was also demonstrated that the loading drug onto TNGs greatly decreased the cytotoxicity of the drug onto HeLa cells. The results offered evidence that SMGO-based TNGs can serve as novel nanocarriers for anti-cancer drug delivery.