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Journal of Nanoparticle Research

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01.03.2017 | Research Paper

Effects of PEGylation on biomimetic synthesis of magnetoferritin nanoparticles

verfasst von: Caiyun Yang, Changqian Cao, Yao Cai, Huangtao Xu, Tongwei Zhang, Yongxin Pan

Erschienen in: Journal of Nanoparticle Research | Ausgabe 3/2017

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Abstract

Recent studies have demonstrated that ferrimagnetic magnetoferritin nanoparticles are a promising novel magnetic nanomaterial in biomedical applications, including biocatalysis, imaging, diagnostics, and tumor therapy. Here we investigated the PEGylation of human H-ferritin (HFn) proteins and the possible influence on biomimetic synthesis of magnetoferritin nanoparticles. The outer surface of HFn proteins was chemically modified with different PEG molecular weights (PEG10K and PEG20K) and different modification ratios (HFn subunit:PEG20K = 1:1, 1:2, 1:4). The PEGylated HFn proteins were used for biomimetic synthesis of ferrimagnetic magnetoferritin nanoparticles. We found that, compared with magnetoferritin using non-PEGylated HFn protein templates, the synthesized magnetoferritin using the PEGylated HFn protein templates possessed larger magnetite cores, higher magnetization and relaxivity values, and improved thermal stability. These results suggest that the PEGylation of H-ferritin may improve the biomineralization of magnetoferritin nanoparticles and enhance their biomedical applications.

Vorheriger Artikel Genesis of flake-like morphology and dye-sensitized solar cell performance of Al-doped ZnO particles: a study

Nächster Artikel Transport and abatement of fluorescent silica nanoparticle (SiO2 NP) in granular filtration: effect of porous media and ionic strength

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Titel: Effects of PEGylation on biomimetic synthesis of magnetoferritin nanoparticles
verfasst von: Caiyun Yang
Changqian Cao
Yao Cai
Huangtao Xu
Tongwei Zhang
Yongxin Pan
Publikationsdatum: 01.03.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 3/2017
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-3805-y

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