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Erschienen in:
2016 | OriginalPaper | Buchkapitel
Ex vivo Evaluation of Transdermal Drug Delivery by Means of Electroporation with in vivo Oriented Experimental Protocols
verfasst von : B. Zorec, J. Jelenc, D. Miklavčič, N. Pavšelj
Erschienen in: 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
Verlag: Springer Singapore
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Due to low permeability of the stratum corneum, different enhancement techniques are required to promote transport of larger molecules across the skin. In our present study we focused on skin electroporation with emphasis on the design of the experimental system and experimental protocols. With this approach the results and the conclusions drawn have greater relevance for in vivo use and later translation into clinical practice. Our results show a statistically significant enhancement of calcein delivery (after one hour of passive diffusion following treatment) already after only 6x100 short (100
μ
s) high voltage (200 V) electrical pulses.