Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Polymer Bulletin
Erschienen in: Polymer Bulletin 6/2019

27.09.2018 | Original Paper

Fabrication and evaluation of pH-dependent polymeric microspheres of ivabradine and their in vitro and in vivo studies

verfasst von: Abdul Majeed, Nazar Muhammad Ranjha, Mussadique Hussain, Muhammad Fawad Rasool

Erschienen in: Polymer Bulletin | Ausgabe 6/2019

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The aim of this work was the development and evaluation of controlled release formulations consisting of methacrylate derivatives and ethyl cellulose synthesized using oil-in-oil solvent evaporation method. Drug release studies were performed in different dissolution media. Maximum drug released was observed at pH 7.4. Fourier transform infrared spectroscopy spectra, SEM and thermal analysis showed compatibility between drug and polymers. Pharmacokinetic parameters were calculated by Phoenix WinNonlin® version 6.3 software. The average AUC0–t was found to be 2483.71 ± 13.173 ng/ml h, 5954.37 ± 12.110 ng/ml h, 6400.82 ± 19.131 ng/ml h and 7427.4 ± 49.322 ng/ml h for group 1–4, respectively. The maximum concentration (Cmax) of IBH for all groups predicted from pharmacokinetics data was 880.38 ng/ml, 718.43 ng/ml, 721.87 ng/ml and 805.11 ng/ml, respectively. Thus, in vitro and in vivo drug release studies of polymeric microspheres proved their controlled release behavior with preferential delivery for an extended period of time.
Vorheriger Artikel Synthesis and enhanced microwave absorption properties of urchin-like polyaniline/Ni0.4Zn0.4Co0.2Fe2O4 composites
Nächster Artikel Pectin–curcumin composite: synthesis, molecular modeling and cytotoxicity

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Freiberg S, Zhu X (2004) Polymer microspheres for controlled drug release. Int J Pharm 282:1–18CrossRefPubMed
2.
Kim B, Hwang S, Park J, Park HJ (2002) Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method. J Microencapsul 19:811–822CrossRefPubMed
3.
Aydin O, Aydin B, Tezcaner A, Keskin D (2015) Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres. J Appl Polym Sci 132:1–13CrossRef
4.
Mutalik S, Udupa N (2005) Formulation development, in vitro and in vivo evaluation of membrane controlled transdermal systems of glibenclamide. J Pharm Pharm Sci 8:26–38PubMed
5.
Verma S, Kaul M, Rawat A, Saini S (2011) An overview on buccal drug delivery system. IJPSR 2:1303–1321
6.
Alagusundaram M, Chengaiah B, Ramkanth S, Parameswari SA, Madhu C, Chetty S, Dhachinamoorthi D (2009) Formulation and evaluation of mucoadhesive buccal films of ranitidine. Int J PharmTech Res 1:557–563
7.
Difrancesco D, Camm JA (2004) Heart rate lowering by specific and selective If current inhibition with ivabradine. Drugs 64:1757–1765CrossRefPubMed
8.
Nawarskas JJ, Bowman BN, Anderson J (2015) Ivabradine: a unique and intriguing medication for treating cardiovascular disease. Cardiol Rev 23:201–211CrossRefPubMed
9.
Nar G, Inci S, Aksan G, Demirelli S, Soylu K, Yuksel S, Gulel O, Icli A (2015) Ivabradine on aortic stiffness in patients with heart failure. J Investig Med 63:620–625CrossRefPubMed
10.
Zhang Y, Sun W, Pan Y, Li T, Yang X, Xu R, Qiu X (2016) Pharmacokinetics changes of ivabradine and N-desmethyl ivabradine after oral administration with puerarin in rats. Int J Clin Exp Med. 9:8369–8374
11.
Prasad UK, Gray D, Purcell H (2009) Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina. Adv Ther 26:127–137CrossRefPubMed
12.
Guo Y-J, Liang D-L, Xu Z-S, Ye Q (2014) In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. Die Pharm An IJPS 69:367–370
13.
Kılıçarslan M, Baykara T (2003) The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. Int J Pharm 252:99–109CrossRefPubMed
14.
Dupinder K, Seema S (2014) Development and characterization of lovastatin loaded microspheres. IJPDT 4:71–78
15.
Jain SK, Awasthi A, Jain N, Agrawal G (2005) Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: Preparation and in vitro characterization. J Control Release 107:300–309CrossRefPubMed
16.
Mundargi RC, Srirangarajan S, Agnihotri SA, Patil SA, Ravindra S, Setty SB, Aminabhavi TM (2007) Development and evaluation of novel biodegradable microspheres based on poly (d, l-lactide-co-glycolide) and poly (ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: in vitro and in vivo studies. J Control Release 119:59–68CrossRefPubMed
17.
Goldmann AS, Barner L, Kaupp M, Vogt AP, Barner-Kowollik C (2012) Orthogonal ligation to spherical polymeric microparticles: modular approaches for surface tailoring. Prog Polym Sci 37:975–984CrossRef
18.
Joshi GV, Kevadiya BD, Bajaj HC (2010) Design and evaluation of controlled drug delivery system of buspirone using inorganic layered clay mineral. Microporous Mesoporous Mater 132:526–530CrossRef
19.
Lim S, Martin GP, Berry D, Brown M (2000) Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J Control Release 66:281–292CrossRefPubMed
20.
Pérez-Martínez JI, Morillo E, Maqueda C, Gines JM (2001) Ethyl cellulose polymer microspheres for controlled release of norfluazon. Pest Manag Sci 57:688–694CrossRefPubMed
21.
Duffull SB, Chabaud S, Nony P, Laveille C, Girard P, Aarons L (2000) A pharmacokinetic simulation model for ivabradine in healthy volunteers. Eur J Pharm Sci 10:285–294CrossRefPubMed
22.
Riesen S, Ni W, Carnes C, Lindsey K, Phelps M, Schober K (2011) Pharmacokinetics of oral ivabradine in healthy cats. J Vet Pharmacol Ther 34:469–475CrossRefPubMed
23.
Westerhout J, Ploeger B, Smeets J, Danhof M, De Lange EC (2012) Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats. AAPS J 14:543–553CrossRefPubMedPubMedCentral
24.
Lu C, Jia Y, Yang J, Jin X, Song Y, Liu W, Ding Y, Sun X, Wen A (2012) Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study. APSB 2:205–212
25.
Arabi H, Hashemi S, Fooladi M (1996) Microencapsulation of allopurinol by solvent evaporation and controlled release investigation of drugs. J Microencapsul 13:527–535CrossRefPubMed
26.
Sahoo SK, Mallick AA, Barik B, Senapati PC (2005) Formulation and in vitro evaluation of Eudragit® microspheres of stavudine. Trop J Pharm Res 4:369–375
27.
Soppimath KS, Kulkarni AR, Aminabhavi TM (2001) Development of hollow microspheres as floating controlled-release systems for cardiovascular drugs: preparation and release characteristics. Drug Dev Ind Pharm 27:507–515CrossRefPubMed
28.
Wadood A, Riaz M, Jamal SB, Shah M, Lodhi MA (2013) Molecular docking study of P4-Benzoxaborolesubstituted ligands as inhibitors of HCV NS3/4A protease. Bioinformation 9:309–314CrossRefPubMedPubMedCentral
29.
Naeem M, Mahmood A, Khan S, Shahiq Z (2010) Development and evaluation of controlled-release bilayer tablets containing microencapsulated tramadol and acetaminophen. Trop J Pharm Res 9:347–354CrossRef
30.
Hao S, Wang B, Wang Y, Zhu L, Wang B, Guo T (2013) Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method. Colloids Surf B 108:127–133CrossRef
31.
Moustafine RI, Bodrov AV, Kemenova VA, Rombaut P, Van Den Mooter G (2012) Drug release modification by interpolymer interaction between countercharged types of Eudragit® RL 30D and FS 30D in double-layer films. Int J Pharm 439:17–21CrossRefPubMed
32.
Ibrahim MA, Shazly GA, El-Badry M (2015) Albendazole microparticles prepared by spray drying technique: improvement of drug dissolution. Trop J Pharm Res 13:1963–1970CrossRef
33.
Kim NA, Choi DH, Lim JY, Kim KH, Lim DG, Lee E, Park E-S, Jeong SH (2014) Investigation of polymeric excipients for dutasteride solid dispersion and its physicochemical characterization. Arch Pharm Res 37:214–224CrossRefPubMed
34.
Ramesh Babu V, Krishna Rao K, Sairam M, Naidu B, Hosamani KM, Aminabhavi TM (2006) pH sensitive interpenetrating network microgels of sodium alginate-acrylic acid for the controlled release of ibuprofen. J Appl Polym Sci 99:2671–2678CrossRef
35.
Dang T, Cui Y, Chen Y, Meng X, Tang B, Wu J (2015) Preparation and characterization of colon-specific microspheres of diclofenac for colorectal cancer. Trop J Pharm Res 14:1541–1547
36.
Chella N, Yada KK, Vempati R (2010) Preparation and evaluation of ethyl cellulose microspheres containing diclofenac sodium by novel w/o/o emulsion method. J Pharm Sci Res 2:884–888
37.
Selva Kumar P, Pandiyan K, Rajagopal K (2014) Development and validation of rapid RP-HPLC method for dissolution release of ivabradine hydrochloride in solid oral dosage form. WJPPS 3:1877–1888
38.
Khan F, Razzak MSMI, Khan MZR, Azam KR, Sadat SMA, Reza MS (2008) Preparation and in vitro evaluation of theophylline loaded gastroretentive floating tablets of METHOCEL K4M. Dhaka Univ J Pharm Sci 7:65–70CrossRef
39.
Feng MR, Lou X, Brown RR, Hutchaleelaha A (2000) Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics. Pharm Res 17:410–418CrossRefPubMed
40.
Khan H, Hanif M (2017) Ivabradine loaded solid lipid microparticles: formulation, characterization and optimization by central composite rotatable design. Acta Pol Pharm 74:211–226PubMed
41.
Lodhi M, Dubey A, Narayan R, Prabhu P, Priya S (2013) Formulation and evaluation of buccal film of Ivabradine hydrochloride for the treatment of stable angina pectoris. Int J Pharm Investig 3:47–53CrossRefPubMedPubMedCentral
42.
Tulain UR, Ahmad M, Rashid A, Malik MZ, Iqbal FM (2018) Fabrication of pH-responsive hydrogel and its in vitro and in vivo evaluation. Adv Polym Technol 37:290–304CrossRef
43.
Ramteke KH, Nath L (2012) Formulation, evaluation and optimization of controlled release hydrogel microspheres for colon targeted drug delivery. J Pharm Sci Res 4:1739–1747
44.
Oprea A-M, Nistor M-T, Profire L, Popa MI, Lupusoru CE, Vasile C (2013) Evaluation of the controlled release ability of theophylline from xanthan/chondroitin sulfate hydrogels. JBNB 4:123–131CrossRef
45.
Ranjha NM, Madni A, Bakar AA, Talib N, Ahmad S, Ahmad H (2014) Preparation and characterization of isosorbide mononitrate hydrogels obtained by free-radical polymerization for site-specific delivery. Trop J Pharm Res 13:1979–1985CrossRef
Metadaten
Titel
Fabrication and evaluation of pH-dependent polymeric microspheres of ivabradine and their in vitro and in vivo studies
verfasst von
Abdul Majeed
Nazar Muhammad Ranjha
Mussadique Hussain
Muhammad Fawad Rasool
Publikationsdatum
27.09.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 6/2019
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-018-2546-0

Weitere Artikel der Ausgabe 6/2019

Polymer Bulletin 6/2019 Zur Ausgabe

Original Paper

Pectin–curcumin composite: synthesis, molecular modeling and cytotoxicity

Original Paper

Microwave-assisted esterification step of poly(ethylene terephthalate) (PET) synthesis through ethylene glycol and terephthalic acid

Original Paper

The potential use of gentamicin sulfate-loaded poly(l-lactic acid)-sericin hybrid scaffolds for bone tissue engineering

Original Paper

Effect of incompletely condensed tri-silanol-phenyl-POSS on the thermal stability of silicone rubber

Review

Advances in the synthesis of non-isocyanate polyurethanes

Original Paper

Multi-walled carbon nanotubes buckypaper/epoxy composites: effect of loading and pressure on tensile and electrical properties

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise