Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Colloid and Polymer Science
Erschienen in: Colloid and Polymer Science 1/2021

05.11.2020 | Original Contribution

Fatty acid-peptide-bioconjugated micellar nanocarrier as a new delivery system for l-asparaginase: multi-criteria optimization, characterization, and pharmacokinetic study

verfasst von: Hajar Ashrafi, Amir Azadi, Soliman Mohammadi-Samani, Younes Ghasemi, Saeid Daneshamouz

Erschienen in: Colloid and Polymer Science | Ausgabe 1/2021

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

l-Asparaginase-fatty acid bioconjugate was prepared by coupling the carboxyl group of fatty acids to NH2 groups of lysine of the enzyme. In this study, the physicochemical properties of l-asparaginase were modified by incorporating surfactant with this amphiphilic structure. The preparation process of micellar nanocarrier was optimized by a systematic multi-criteria optimization approach in terms of particle size and enzyme activity. The final particle size, PDI, and enzyme activity were 387.6 ± 9.8 nm, 0.341 ± 0.031, and 92.1 ± 1.3%, respectively. Results are in an optimum condition. Furthermore, results showed that the optimized formulation is more resistant to proteolysis, is more stable at different pH (6.5 to 10), and has prolonged plasma half-life (56.8 h) in comparison to the native enzyme. Also, the longevity in the circulation by micellar nanocarriers was confirmed by the data on the pharmacokinetic study. This method can be used as a suitable method to provide a new formulation of l-asparaginase for the treatment of related diseases.
Graphical abstract
Vorheriger Artikel Hybrids containing zirconium and phosphorus compounds obtained by sol-gel method
Nächster Artikel Rheology of thermo-gelling capillary suspensions

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Ashihara Y, Kono T, Yamazaki S, Inada Y (1978) Modification of E. coli L-asparaginase with polyethylene glycol: disappearance of binding ability to anti-asparaginase serum. Biochem Biophys Res Commun 83(2):385–391PubMedCrossRef
2.
Chen S-H (2015) Asparaginase therapy in pediatric acute lymphoblastic leukemia: a focus on the mode of drug resistance. Pediatr Neonatol 56(5):287–293PubMedCrossRef
3.
Vervliet T, Parys JB (2019) l-Asparaginase-induced apoptosis in ALL cells involves IP3 receptor signaling. Cell Calcium 83:102076PubMedCrossRef
4.
Graham ML (2003) Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev 55(10):1293–1302PubMedCrossRef
5.
Muneer F, Siddique MH, Azeem F, Rasul I, Muzammil S, Zubair M, Afzal M, Nadeem H (2020) Microbial L-asparaginase: purification, characterization and applications. Arch Microbiol 202(1):967–981PubMedCrossRef
6.
Shrivastava A, Khan AA, Khurshid M, Kalam MA, Jain SK, Singhal PK (2016) Recent developments in l-asparaginase discovery and its potential as anticancer agent. Crit Rev Oncol Hematol 100(1):1–10PubMedCrossRef
7.
Cristóvão RO, Almeida MR, Barros MA, Nunes JCF, Boaventura RAR, Loureiro JM, Faria JL, Neves MC, Freire MG, Ebinuma-Santos VC (2020) Development and characterization of a novel l-asparaginase/MWCNT nanobioconjugate. RSC Adv 10(52):31205–31213CrossRefPubMedPubMedCentral
8.
Fernandes AI, Gregoriadis G (2001) The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: implication in its pharmacokinetics. Int J Pharm 217(1–2):215–224PubMedCrossRef
9.
Zhang Y-Q, Zhou W-L, Shen W-D, Chen Y-H, Zha X-M, Shirai K, Kiguchi K (2005) Synthesis, characterization and immunogenicity of silk fibroin-l-asparaginase bioconjugates. J Biotechnol 120(3):315–326PubMedCrossRef
10.
Zhang YQ, Tao ML, Shen WD, Mao JP, Chen Y (2006) Synthesis of silk sericin peptides–l-asparaginase bioconjugates and their characterization. J Chem Technol Biotechnol 81(2):136–145CrossRef
11.
Tabandeh MR, Aminlari M (2009) Synthesis, physicochemical and immunological properties of oxidized inulin-l-asparaginase bioconjugate. J Biotechnol 141(3–4):189–195PubMedCrossRef
12.
Guoqiang Q, Juyan Z, Jianbiao M, Binglin H, Daobin W (1997) Chemical modification of l-asparaginase with N,O-carboxymethyl chitosan and its effects on plasma half-life and other properties. Science in China 40(4):337–341
13.
Chahardahcherik M, Ashrafi M, Ghasemi Y, Aminlari M (2020) Effect of chemical modification with carboxymethyl dextran on kinetic and structural properties of L-asparaginase. Anal Biochem 591:113537PubMedCrossRef
14.
Baskar G, Lalitha K, Garrick BG, Chamundeeswari M (2017) Conjugation, labeling and characterization of asparaginase bound silver nanoparticles for anticancer applications
15.
Agrawal S, Sharma I, Prajapati BP, Suryawanshi RK, Kango N (2018) Catalytic characteristics and application of l-asparaginase immobilized on aluminum oxide pellets. Int J Biol Macromol 114:504–511PubMedCrossRef
16.
Do TT, Do TP, Nguyen TN, Nguyen TC, Vu TTP, Nguyen TGA (2019) Nanoliposomal L-asparaginase and its antitumor activities in Lewis lung carcinoma tumor-induced BALB/c mice. Adv Mater Sci Eng 2019(1):2–9
17.
Orhan H, Uygun DA (2020) Immobilization of L-asparaginase on magnetic nanoparticles for cancer treatment. Appl Biochem Biotechnol 191:1432–1443PubMedCrossRef
18.
Ashrafi H, Amini M, Mohammadi-Samani S, Ghasemi Y, Azadi A, Tabandeh MR, Kamali-Sarvestani E, Daneshamouz S (2013) Nanostructure l-asparaginase-fatty acid bioconjugate: synthesis, preformulation study and biological assessment. Int J Biol Macromol 62:180–187PubMedCrossRef
19.
Hamidi M, Ashrafi H, Azadi A (2012) Surface functionalized hydrogel nanoparticles. In: Tiwari A, Ramalingam M, Kobayashi H, Turner APF (eds) Biomedical materials and diagnostic devices. John Wiley & Sons, Beverly
20.
Singh Bakshi M, Singh J, Kaur G (2005) Mixed micelles of monomeric and dimeric cationic surfactants with phospholipids: effect of hydrophobic interactions. Chem Phys Lipids 138:81–92CrossRef
21.
Kakehashi R, Shizuma M, Yamamura S, Takeda T (2004) Mixed micelles containing sodium oleate: the effect of the chain length and the polar head group. J Colloid Interface Sci 279(1):253–258PubMedCrossRef
22.
Leiro J, Siso MIG, Ortega M, Santamarina MT, Sanmartin ML (1995) A factorial experimental design for investigation of the effects of temperature, incubation time, and pathogen-to-phagocyte ratio on in vivo phagocytosis by turbot adherent cells. Comp Biochem Physiol C Toxicol Pharmacol 112(2):215–220
23.
Barati M, Samani SM, Jahromi LP, Ashrafi H, Azadi A (2018) Controlled-release in-situ gel forming formulation of tramadol containing chitosan-based pro-nanogels. Int J Biol Macromol 118:1449–1454PubMedCrossRef
24.
Sharma G, Goyal AK, Singh AP (2019) Application of design of expert for the development and systematic optimisation of L-asparaginase loaded nanoparticulate carrier drug delivery systems. J Drug Deliv Ther 9(3-s):303–308
25.
Hermanson GT (ed) (2008) Bioconjugate techniques, 2nd edn. Academic Press, Oxford
26.
Itaya K (1977) A more sensitive and stable colorimetric determination of free fatty acids in blood. J Lipid Res 18(5):663–665PubMed
27.
Ashrafi H, Azadi A, Mohammadi-Samani S, Ghasemi Y, Daneshamouz S (2020) Preliminary study for the preparation of fatty acid bioconjugated L-asparaginase micellar nanocarrier as a delivery system for peptide anti-cancer agents. Trends Pharmacol Sci 6(3):175–188
28.
Azadi S, Ashrafi H, Azadi A (2017) Mathematical modeling of drug release from swellable polymeric nanoparticles. J Appl Pharm Sci 7(04):125–133
29.
Habeeb AFSA (1966) Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal Biochem 14(3):328–336PubMedCrossRef
30.
Abdellatef HE, Khalil HM (2003) Colorimetric determination of gabapentin in pharmaceutical formulation. J Pharm Biomed Anal 31(1):209–214PubMedCrossRef
31.
Wang R, Xia B, Li BJ, Peng SL, Ding LS, Zhang S (2008) Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization. Int J Pharm 364(1):102–107PubMedCrossRef
32.
Ghosh S, Chaganti SR, Prakasham RS (2012) Polyaniline nanofiber as a novel immobilization matrix for the anti-leukemia enzyme l-asparaginase. J Mol Catal B Enzym 74(1–2):132–137CrossRef
33.
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254PubMedCrossRef
34.
Jambhekar SS, Breen PJ (2009) Basic pharmacokinetics. Pharmaceutical Press, London
35.
Waynforth H, Flecknell P (1992) Experimental and surgical techniques in the rat
36.
Miron J, Siso MIG, Murado MA, Gonzalez MP (1988) Microfungus-yeast mixed cultures in the degradation of amylaceous wastes. II An experimental design for optimization of yeast production. Biotechnol Lett 2(1):171–176
37.
Deming SN (1991) Multiple-criteria optimization. J Chromatogr A 550(1):15–25CrossRef
38.
Derringer G, Suich R (1980) Simultaneous optimization of several response variables. J Qual Technol 12(4):214–219CrossRef
39.
Gao Q, Liang Q, Yu F, Xu J, Zhao Q, Sun B (2011) Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system. Colloids Surf B Biointerfaces 88(2):741–748PubMedCrossRef
40.
England JL (1999) Stabilization and release effects of Pluronic F127 in protein drug delivery. Juventudes Univ Socialistas 5(1):17–24
41.
Soares AL, Guimarães GM, Polakiewicz B, Pitombo RNM, Abrahão-Neto J (2002) Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli-asparaginase. Int J Pharm 237(1–2):163–170PubMedCrossRef
42.
Eldin M, Portaccio M, Diano N, Rossi S, Bencivenga U, D'Uva A, Canciglia P, Gaeta FS, Mita DG (1999) Influence of the microenvironment on the activity of enzymes immobilized on Teflon membranes grafted by γ-radiation. J Mol Catal B Enzym 7(5):251–261CrossRef
43.
Arica MY, Hasirci V (1993) Immobilization of glucose oxidase: a comparison of entrapment and covalent bonding. J Chem Technol Biotechnol 58(3):287–292PubMedCrossRef
44.
Jorge JCS, Perez-Soler R, Morais JG, Cruz MEM (1994) Liposomal palmitoyl-L-asparaginase: characterization and biological activity. Cancer Chemother Pharmacol 34(3):230–234PubMedCrossRef
45.
Dumortier G, Grossiord JL, Agnely F, Chaumeil JC (2006) A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm Res 23(12):2709–2728PubMedCrossRef
46.
Murphy A, Taggart G (2002) A comparison of predicted and experimental critical micelle concentration values of cationic and anionic ternary surfactant mixtures using molecular-thermodynamic theory and pseudophase separation theory. Colloids Surf A Physicochem Eng Asp 205(3):237–248CrossRef
47.
Akhter MS, Alawi SM (2000) The effect of organic additives on critical micelle concentration of non-aqueous micellar solutions. Colloids Surf A Physicochem Eng Asp 175(3):311–320CrossRef
48.
Burlatsky SF, Atrazhev VV, Dmitriev DV, Sultanov VI, Timokhina EN, Ugolkova EA, Tulyani S, Vincitore A (2013) Surface tension model for surfactant solutions at the critical micelle concentration. J Colloid Interface Sci 393(1):151–160PubMedCrossRef
49.
Otzen D (2011) Protein–surfactant interactions: a tale of many states. Biochim Biophys Acta 1814(5):562–591PubMedCrossRef
50.
Vidya J, Ushasree MV, Pandey A (2014) Effect of surface charge alteration on stability of L-asparaginase II from Escherichia sp. Enzym Microb Technol 56:15–19CrossRef
51.
Zhao Z, Ukidve A, Krishnan V, Mitragotri S (2019) Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers. Adv Drug Deliv Rev 143(1):3–21
Metadaten
Titel
Fatty acid-peptide-bioconjugated micellar nanocarrier as a new delivery system for l-asparaginase: multi-criteria optimization, characterization, and pharmacokinetic study
verfasst von
Hajar Ashrafi
Amir Azadi
Soliman Mohammadi-Samani
Younes Ghasemi
Saeid Daneshamouz
Publikationsdatum
05.11.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Colloid and Polymer Science / Ausgabe 1/2021
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI
https://doi.org/10.1007/s00396-020-04775-5

Weitere Artikel der Ausgabe 1/2021

Colloid and Polymer Science 1/2021 Zur Ausgabe

Original Contribution

Enhancing U(VI) adsorptive removal via amidoximed polyacrylonitrile nanofibers with hierarchical porous structure

Original Contribution

Swelling kinetics and rheological behaviour of microwave synthesized poly(acrylamide-co-acrylic acid) hydrogels

Original Contribution

Preparation of monodisperse polystyrene nanoparticles with tunable sizes based on soap-free emulsion polymerization technology

Original Contribution

Synthesis of polymeric surfactant from palm oil methyl ester for enhanced oil recovery application

Original Contribution

Micellar characteristics of an amphiphilic star-block copolymer in DES-water mixture

Original Contribution

Exploring the structure of sol-gel-derived hybrids for immobilization of RNA: Influence of RNA content

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise