Skip to main content

2019 | OriginalPaper | Buchkapitel

FISUL: A Framework for Detecting Adverse Drug Events from Heterogeneous Medical Sources Using Feature Importance

verfasst von : Corinne G. Allaart, Lena Mondrejevski, Panagiotis Papapetrou

Erschienen in: Artificial Intelligence Applications and Innovations

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Adverse drug events (ADEs) are considered to be highly important and critical conditions, while accounting for around 3.7% of hospital admissions all over the world. Several studies have applied predictive models for ADE detection; nonetheless, only a restricted number and type of features has been used. In the paper, we propose a framework for identifying ADEs in medical records, by first applying the Boruta feature importance criterion, and then using the top-ranked features for building a predictive model as well as for clustering. We provide an experimental evaluation on the MIMIC-III database by considering 7 types of ADEs illustrating the benefit of the Boruta criterion for the task of ADE detection.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Bagattini, F., Karlsson, I., Rebane, J., Papapetrou, P.: A classification framework for exploiting sparse multi-variate temporal features with application to adverse drug event detection in medical records. BMC Med. Inform. Decis. Making 19(1), 7 (2019)CrossRef Bagattini, F., Karlsson, I., Rebane, J., Papapetrou, P.: A classification framework for exploiting sparse multi-variate temporal features with application to adverse drug event detection in medical records. BMC Med. Inform. Decis. Making 19(1), 7 (2019)CrossRef
2.
Zurück zum Zitat Bates, D.W., et al.: Patient risk factors for adverse drug events in hospitalized patients. Arch. Intern. Med. 159(21), 2553–2560 (1999)CrossRef Bates, D.W., et al.: Patient risk factors for adverse drug events in hospitalized patients. Arch. Intern. Med. 159(21), 2553–2560 (1999)CrossRef
3.
Zurück zum Zitat Beaulieu-Jones, B.K., Lavage, D.R., Snyder, J.W., Moore, J.H., Pendergrass, S.A., Bauer, C.R.: Characterizing and managing missing structured data in electronic health records: data analysis. JMIR Med. Inform. 6(1), e11 (2018)CrossRef Beaulieu-Jones, B.K., Lavage, D.R., Snyder, J.W., Moore, J.H., Pendergrass, S.A., Bauer, C.R.: Characterizing and managing missing structured data in electronic health records: data analysis. JMIR Med. Inform. 6(1), e11 (2018)CrossRef
4.
Zurück zum Zitat Cao, H., Markatou, M., Melton, G.B., Chiang, M.F., Hripcsak, G.: Handling temporality of clinical events for drug safety surveillance. In: AMIA Proceedings, vol. 2005, pp. 106–110. American Medical Informatics Association (2005) Cao, H., Markatou, M., Melton, G.B., Chiang, M.F., Hripcsak, G.: Handling temporality of clinical events for drug safety surveillance. In: AMIA Proceedings, vol. 2005, pp. 106–110. American Medical Informatics Association (2005)
5.
Zurück zum Zitat Daveluy, A., Raignoux, C., Miremont-Salamé, G., Girodet, P., Moore, N., Haramburu, F., Molimard, M.: Drug interactions between inhaled corticosteroids and enzymatic inhibitors. Eur. J. Clin. Pharmacol. 65(7), 743–745 (2009)CrossRef Daveluy, A., Raignoux, C., Miremont-Salamé, G., Girodet, P., Moore, N., Haramburu, F., Molimard, M.: Drug interactions between inhaled corticosteroids and enzymatic inhibitors. Eur. J. Clin. Pharmacol. 65(7), 743–745 (2009)CrossRef
6.
Zurück zum Zitat Desautels, T., et al.: Using transfer learning for improved mortality prediction in a data-scarce hospital setting. Biomed. Inform. Insights 9, July 2017CrossRef Desautels, T., et al.: Using transfer learning for improved mortality prediction in a data-scarce hospital setting. Biomed. Inform. Insights 9, July 2017CrossRef
7.
Zurück zum Zitat Fitzmaurice, D., Blann, A., Lip, G.: Bleeding risks of antithrombotic therapy. Br. Med. J. 325(7368), 828–831 (2002)CrossRef Fitzmaurice, D., Blann, A., Lip, G.: Bleeding risks of antithrombotic therapy. Br. Med. J. 325(7368), 828–831 (2002)CrossRef
8.
Zurück zum Zitat Freeman, R., Moore, L., García Alvarez, L., Charlett, A., Holmes, A.: Advances in electronic surveillance for healthcare-associated infections in the 21st century: a systematic review. J. Hosp. Infect. 84(2), 106–119 (2013)CrossRef Freeman, R., Moore, L., García Alvarez, L., Charlett, A., Holmes, A.: Advances in electronic surveillance for healthcare-associated infections in the 21st century: a systematic review. J. Hosp. Infect. 84(2), 106–119 (2013)CrossRef
9.
Zurück zum Zitat Gentimis, T., Alnaser, A.J., Durante, A., Cook, K., Steele, R.: Predicting hospital length of stay using neural networks on mimic iii data. In: 2017 IEEE 15th Intl Conf on Dependable, Autonomic and Secure Computing, 15th Intl Conf on Pervasive Intelligence and Computing, 3rd Intl Conf on Big Data Intelligence and Computing and Cyber Science and Technology Congress (DASC/PiCom/DataCom/CyberSciTech), pp. 1194–1201, November 2017 Gentimis, T., Alnaser, A.J., Durante, A., Cook, K., Steele, R.: Predicting hospital length of stay using neural networks on mimic iii data. In: 2017 IEEE 15th Intl Conf on Dependable, Autonomic and Secure Computing, 15th Intl Conf on Pervasive Intelligence and Computing, 3rd Intl Conf on Big Data Intelligence and Computing and Cyber Science and Technology Congress (DASC/PiCom/DataCom/CyberSciTech), pp. 1194–1201, November 2017
10.
Zurück zum Zitat Harpaz, R., Haerian, K., Chase, H.S., Friedman, C.: Mining electronic health records for adverse drug effects using regression based methods. In: The 1st ACM International Health Informatics Symposium, pp. 100–107. ACM (2010) Harpaz, R., Haerian, K., Chase, H.S., Friedman, C.: Mining electronic health records for adverse drug effects using regression based methods. In: The 1st ACM International Health Informatics Symposium, pp. 100–107. ACM (2010)
11.
Zurück zum Zitat Henriksson, A., Kvist, M., Dalianis, H., Duneld, M.: Identifying adverse drug event information in clinical notes with distributional semantic representations of context. J. Biomed. Inform. 57, 333–349 (2015)CrossRef Henriksson, A., Kvist, M., Dalianis, H., Duneld, M.: Identifying adverse drug event information in clinical notes with distributional semantic representations of context. J. Biomed. Inform. 57, 333–349 (2015)CrossRef
12.
Zurück zum Zitat Henriksson, A., Zhao, J., Boström, H., Dalianis, H.: Modeling heterogeneous clinical sequence data in semantic space for adverse drug event detection. In: IEEE International Conference on Data Science and Advanced Analytics, pp. 1–8 (2015) Henriksson, A., Zhao, J., Boström, H., Dalianis, H.: Modeling heterogeneous clinical sequence data in semantic space for adverse drug event detection. In: IEEE International Conference on Data Science and Advanced Analytics, pp. 1–8 (2015)
13.
Zurück zum Zitat Hersh, W.R.: Adding value to the electronic health record through secondary use of data for quality assurance, research, and surveillance. Clin. Pharmacol. Ther. 81, 126–128 (2007)CrossRef Hersh, W.R.: Adding value to the electronic health record through secondary use of data for quality assurance, research, and surveillance. Clin. Pharmacol. Ther. 81, 126–128 (2007)CrossRef
14.
Zurück zum Zitat Hielscher, T., Spiliopoulou, M., Völzke, H., Kühn, J.: Mining longitudinal epidemiological data to understand a reversible disorder. In: International Symposium on Intelligent Data Analysis, pp. 120–130 (2014) Hielscher, T., Spiliopoulou, M., Völzke, H., Kühn, J.: Mining longitudinal epidemiological data to understand a reversible disorder. In: International Symposium on Intelligent Data Analysis, pp. 120–130 (2014)
15.
Zurück zum Zitat Honigman, B., et al.: Using computerized data to identify adverse drug events in outpatients. J. Am. Med. Inform. Assoc. 8(3), 254–266 (2001)CrossRef Honigman, B., et al.: Using computerized data to identify adverse drug events in outpatients. J. Am. Med. Inform. Assoc. 8(3), 254–266 (2001)CrossRef
16.
Zurück zum Zitat Howard, R., Avery, A., Slavenburg, S., Royal, S., Pipe, G., Lucassen, P., Pirmohamed, M.: Which drugs cause preventable admissions to hospital? a systematic review. Br. J. Clin. Pharmacol. 63(2), 136–147 (2007)CrossRef Howard, R., Avery, A., Slavenburg, S., Royal, S., Pipe, G., Lucassen, P., Pirmohamed, M.: Which drugs cause preventable admissions to hospital? a systematic review. Br. J. Clin. Pharmacol. 63(2), 136–147 (2007)CrossRef
17.
Zurück zum Zitat Jensen, P.B., Jensen, L.J., Brunak, S.: Mining electronic health records: towards better research applications and clinical care. Nature Rev. Genet. 13(6), 395–405 (2012)CrossRef Jensen, P.B., Jensen, L.J., Brunak, S.: Mining electronic health records: towards better research applications and clinical care. Nature Rev. Genet. 13(6), 395–405 (2012)CrossRef
18.
Zurück zum Zitat Kursa, M., Rudnicki, W.: Feature selection with the boruta package. J. Stat. Softw. 36(11), 1–13 (2010)CrossRef Kursa, M., Rudnicki, W.: Feature selection with the boruta package. J. Stat. Softw. 36(11), 1–13 (2010)CrossRef
19.
Zurück zum Zitat Kursa, M.B., Jankowski, A., Rudnicki, W.R.: Boruta - a system for feature selection. Fundam. Inf. 101(4), 271–285 (2010)MathSciNet Kursa, M.B., Jankowski, A., Rudnicki, W.R.: Boruta - a system for feature selection. Fundam. Inf. 101(4), 271–285 (2010)MathSciNet
20.
Zurück zum Zitat Kury, F., Bodenreider, O.: Desiderata for drug classification systems for their use in analyzing large drug prescription datasets. In: Proceedings of the 3rd Workshop on Data Mining for Medical Informatics (2016) Kury, F., Bodenreider, O.: Desiderata for drug classification systems for their use in analyzing large drug prescription datasets. In: Proceedings of the 3rd Workshop on Data Mining for Medical Informatics (2016)
21.
Zurück zum Zitat Nebeker, J.R., Barach, P., Samore, M.H.: Clarifying adverse drug events: a clinician’s guide to terminology, documentation, and reporting. Ann. Internal Med. 140(10), 795–801 (2004)CrossRef Nebeker, J.R., Barach, P., Samore, M.H.: Clarifying adverse drug events: a clinician’s guide to terminology, documentation, and reporting. Ann. Internal Med. 140(10), 795–801 (2004)CrossRef
22.
Zurück zum Zitat Norén, G.N., Bergvall, T., Ryan, P.B., Juhlin, K., Schuemie, M.J., Madigan, D.: Empirical performance of the calibrated self-controlled cohort analysis within temporal pattern discovery: lessons for developing a risk identification and analysis system. Drug Saf. 36(1), 107–121 (2013)CrossRef Norén, G.N., Bergvall, T., Ryan, P.B., Juhlin, K., Schuemie, M.J., Madigan, D.: Empirical performance of the calibrated self-controlled cohort analysis within temporal pattern discovery: lessons for developing a risk identification and analysis system. Drug Saf. 36(1), 107–121 (2013)CrossRef
23.
Zurück zum Zitat Ouchi, K., Lindvall, C., Chai, P.R., Boyer, E.W.: Machine learning to predict, detect, and intervene older adults vulnerable for adverse drug events in the emergency department. J. Med. Toxicol. 14(3), 248–252 (2018)CrossRef Ouchi, K., Lindvall, C., Chai, P.R., Boyer, E.W.: Machine learning to predict, detect, and intervene older adults vulnerable for adverse drug events in the emergency department. J. Med. Toxicol. 14(3), 248–252 (2018)CrossRef
24.
Zurück zum Zitat Pakhomov, S.V., Buntrock, J., Chute, C.G.: Prospective recruitment of patients with congestive heart failure using an ad-hoc binary classifier. J. Biomed. Inform. 38(2), 145–153 (2005)CrossRef Pakhomov, S.V., Buntrock, J., Chute, C.G.: Prospective recruitment of patients with congestive heart failure using an ad-hoc binary classifier. J. Biomed. Inform. 38(2), 145–153 (2005)CrossRef
25.
Zurück zum Zitat Park, M.Y., et al.: A novel algorithm for detection of adverse drug reaction signals using a hospital electronic medical record database. Pharmacoepidemiol. Drug Saf. 20(6), 598–607 (2011)CrossRef Park, M.Y., et al.: A novel algorithm for detection of adverse drug reaction signals using a hospital electronic medical record database. Pharmacoepidemiol. Drug Saf. 20(6), 598–607 (2011)CrossRef
26.
Zurück zum Zitat van Puijenbroek, E.P., Bate, A., Leufkens, H.G., Lindquist, M., Orre, R., Egberts, A.C.: A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions. Pharmacoepidemiol. Drug Saf. 11(1), 3–10 (2002)CrossRef van Puijenbroek, E.P., Bate, A., Leufkens, H.G., Lindquist, M., Orre, R., Egberts, A.C.: A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions. Pharmacoepidemiol. Drug Saf. 11(1), 3–10 (2002)CrossRef
27.
Zurück zum Zitat Rousseeuw, P.J.: Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J. Comput. Appl. Math. 20, 53–65 (1987)CrossRef Rousseeuw, P.J.: Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J. Comput. Appl. Math. 20, 53–65 (1987)CrossRef
28.
Zurück zum Zitat Sarker, A., et al.: Utilizing social media data for pharmacovigilance: a review. J. Biomed. Inform. 54, 202–212 (2015)CrossRef Sarker, A., et al.: Utilizing social media data for pharmacovigilance: a review. J. Biomed. Inform. 54, 202–212 (2015)CrossRef
29.
Zurück zum Zitat Schuemie, M.J., et al.: Using electronic health care records for drug safety signal detection: a comparative evaluation of statistical methods. Med. Care 50(10), 890–897 (2012)CrossRef Schuemie, M.J., et al.: Using electronic health care records for drug safety signal detection: a comparative evaluation of statistical methods. Med. Care 50(10), 890–897 (2012)CrossRef
30.
Zurück zum Zitat Scott, D.J., et al.: Accessing the public mimic-ii intensive care relational database for clinical research. BMC Med. Inform. Decis. 13(1), 9 (2013)CrossRef Scott, D.J., et al.: Accessing the public mimic-ii intensive care relational database for clinical research. BMC Med. Inform. Decis. 13(1), 9 (2013)CrossRef
31.
Zurück zum Zitat Uzuner, Ö., Goldstein, I., Luo, Y., Kohane, I.: Identifying patient smoking status from medical discharge records. J. Am. Med. Inform. Assoc. 15(1), 14–24 (2008)CrossRef Uzuner, Ö., Goldstein, I., Luo, Y., Kohane, I.: Identifying patient smoking status from medical discharge records. J. Am. Med. Inform. Assoc. 15(1), 14–24 (2008)CrossRef
32.
Zurück zum Zitat Weiskopf, N.G., Hripcsak, G., Swaminathan, S., Weng, C.: Defining and measuring completeness of electronic health records for secondary use. J. Biomed. Inform. 46(5), 830–836 (2013)CrossRef Weiskopf, N.G., Hripcsak, G., Swaminathan, S., Weng, C.: Defining and measuring completeness of electronic health records for secondary use. J. Biomed. Inform. 46(5), 830–836 (2013)CrossRef
33.
Zurück zum Zitat Zhao, J., Henriksson, A., Asker, L., Boström, H.: Predictive modeling of structured electronic health records for adverse drug event detection. BMC Med. Inform. Decis. Making 15(Suppl 4), S1 (2015)CrossRef Zhao, J., Henriksson, A., Asker, L., Boström, H.: Predictive modeling of structured electronic health records for adverse drug event detection. BMC Med. Inform. Decis. Making 15(Suppl 4), S1 (2015)CrossRef
Metadaten
Titel
FISUL: A Framework for Detecting Adverse Drug Events from Heterogeneous Medical Sources Using Feature Importance
verfasst von
Corinne G. Allaart
Lena Mondrejevski
Panagiotis Papapetrou
Copyright-Jahr
2019
DOI
https://doi.org/10.1007/978-3-030-19823-7_11

Premium Partner