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Quality of Life Research
Erschienen in: Quality of Life Research 8/2016

20.01.2016

Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease

verfasst von: Christine R. Borge, Anne M. Mengshoel, Torbjørn Moum, Astrid K. Wahl

Erschienen in: Quality of Life Research | Ausgabe 8/2016

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Abstract

Purpose

How changes in depression and anxiety and well-being may fluctuate with changes in disease-specific quality of life (QOL), and further how changes in well-being may fluctuate with changes in depression and anxiety among patients with moderate and severe chronic obstructive pulmonary disease (COPD).

Methods

In a longitudinal study (as part of a randomized controlled trial), we investigated 150 patients with moderate and severe COPD at baseline, 143 at 4 weeks, and 130 at 4 months. Lung function was tested, and a questionnaire was completed at all appointments. The questions captured demographic variables, disease-specific QOL (St. George’s Respiratory Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), and well-being (World Health Organization-5 Well-being Index). Multiple regression analyses were performed.

Results

At 4 weeks and 4 months, changes in disease-specific QOL (st. β = –0.35, p < 0.001, partial (p) R 2 = 11–12 %), depression (st. β = –0.32 to –0.36, p < 0.001, pR 2 = 9–12 %), and anxiety (st. β = –0.21 to –0.40, p < 0.02–0.001, pR 2 = 4–15 %) were significantly associated with changes in well-being. Changes in disease-specific QOL were significantly associated with changes in anxiety at 4 months (st. β = 0.21, p = 0.02, pR 2 = 4 %), but not with changes in depression.

Conclusions

Changes in disease-specific QOL, depression, and anxiety were associated with changes in well-being. Changes in disease-specific QOL contributed slightly to changes in anxiety, but not to changes in depression. Well-being may capture some aspects of mental QOL in COPD patients better than depression and anxiety.
Vorheriger Artikel Health-related quality-of-life improvements during 98 weeks of infliximab therapy in patients with plaque-type psoriasis in real-world practice
Nächster Artikel Is health-related quality of life between 90 and 180 days following stroke associated with long-term unmet needs?

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Metadaten
Titel
Fluctuating patterns in quality of life outcomes among patients with moderate and severe stages of chronic obstructive pulmonary disease
verfasst von
Christine R. Borge
Anne M. Mengshoel
Torbjørn Moum
Astrid K. Wahl
Publikationsdatum
20.01.2016
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 8/2016
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1227-4

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