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Erschienen in:
Big Data Analytics and Fuzzy Technology: Extracting Information from Social Data Kapitel lesen Erstes Kapitel lesen

2018 | OriginalPaper | Buchkapitel

Fuzzy Physiologically Based Pharmacokinetic (PBPK) Model of Chloroform in Swimming Pools

verfasst von : R. A. Dyck, R. Sadiq, M. J. Rodriguez

Erschienen in: Recent Developments and the New Direction in Soft-Computing Foundations and Applications

Verlag: Springer International Publishing

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Abstract

Chloroform is one of the most prevalent disinfection byproducts (DBPs) formed in swimming pools through reactions between disinfectants and organic contaminants. Chloroform and related DBPs have been a subject of research in exposure and human health risk assessments over the last several decades. Physiologically based pharmacokinetic (PBPK) models are one tool that is being used increasingly by researchers to evaluate the health impacts of swimming pool exposures. These models simulate the absorption, distribution, metabolism and excretion of chemicals in the human body to assess doses to sensitive organs. As with any model, uncertainties arise from variability and imprecision in inputs. Among the most uncertain model parameters are the partition coefficients which describe uptake and distribution of chemical to different tissues of the body. In this paper, a fuzzy based model is presented for improving the description and incorporation of uncertain parameters into the model. The fuzzy PBPK model compares well with the deterministic model and measured concentrations while providing more information about uncertainty.

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Vorheriges Kapitel A Survey of the Applications of Fuzzy Methods in Recommender Systems
Nächstes Kapitel Mamdani-Type Fuzzy Inference System for Evaluation of Tax Potential
Fußnoten
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While models that evaluate environmental exposures are technically considered “toxico” kinetic models, much of the literature refers to PBPK because the pharmaceutical industry originally drove much of this research. The terms will be used interchangeably here.
 
2
For more detailed discussion of fuzzy sets, fuzzy numbers, fuzzy arithmetic and their use in modeling, see [48, 49‐52].
 
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Metadaten
Titel
Fuzzy Physiologically Based Pharmacokinetic (PBPK) Model of Chloroform in Swimming Pools
verfasst von
R. A. Dyck
R. Sadiq
M. J. Rodriguez
Copyright-Jahr
2018
Buch
Recent Developments and the New Direction in Soft-Computing Foundations and Applications

Print ISBN: 978-3-319-75407-9

Electronic ISBN: 978-3-319-75408-6

Copyright-Jahr: 2018

DOI
https://doi.org/10.1007/978-3-319-75408-6_38