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2013 | OriginalPaper | Buchkapitel

Galleria Mellonella as a Model Host to Study Gut Microbe Homeostasis and Brain Infection by the Human Pathogen Listeria Monocytogenes

verfasst von : Krishnendu Mukherjee, Ramya Raju, Rainer Fischer, Andreas Vilcinskas

Erschienen in: Yellow Biotechnology I

Verlag: Springer Berlin Heidelberg

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Abstract

The gastrointestinal tract in both mammals and insects is associated with microbes (collectively the microbiota), which are controlled by the intestinal immune system. These microbes regulate pathogens that can infect gut epithelial cells, and there is increasing evidence for a reciprocal relationship between beneficial and pathogenic bacteria in the gut and the intestinal immune system. Deciphering these complex interactions between the microbiota and intestinal immune system in mammals requires surrogate model systems, such as larvae of the greater wax moth Galleria mellonella. The exposure of G. mellonella microbiota to antibiotics induces immunity and stress-related genes in the intestine. The model can also provide insight into the virulence mechanisms of pathogens such as Listeria monocytogenes in the human gut and brain. We also discuss the current uses of G. mellonella as a model to develop therapeutic strategies against listeriosis.

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Vorheriges Kapitel Utility of Insects for Studying Human Pathogens and Evaluating New Antimicrobial Agents

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Titel: Galleria Mellonella as a Model Host to Study Gut Microbe Homeostasis and Brain Infection by the Human Pathogen Listeria Monocytogenes
verfasst von: Krishnendu Mukherjee
Ramya Raju
Rainer Fischer
Andreas Vilcinskas
Verlag: Springer Berlin Heidelberg
Buch: Yellow Biotechnology I
Print ISBN: 978-3-642-39862-9

Electronic ISBN: 978-3-642-39863-6

Copyright-Jahr: 2013
DOI: https://doi.org/10.1007/10_2013_203

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