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Journal of Nanoparticle Research

Erschienen in:

01.07.2011 | Research paper

Gold nanorod stabilized by thiolated chitosan as photothermal absorber for cancer cell treatment

verfasst von: Chung-Hao Wang, Chia-Wei Chang, Ching-An Peng

Erschienen in: Journal of Nanoparticle Research | Ausgabe 7/2011

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Abstract

Gold nanorod (GNR) has great potential in the field of cancer therapy because of its photophysical property in converting near-infrared (NIR) laser light into heat. Fabrication of GNRs by seed-mediated growth method with the aid of cetyltrimethylammonium bromide (CTAB) is a popular approach. However, due to high cytotoxicity of CTAB, it is necessary to modify the surface of CTAB-passivated GNRs for cell-related studies. In this study, thiolated chitosan was synthesized and harnessed to replace CTAB originally used to stabilize GNRs. The average size and morphological shape of CTAB-passivated GNRs (66.0 nm) and thiolated chitosan-modified GNRs (CGNRs) (84.9 nm) were determined by dynamic light scattering and transmission electron microscopy. X-ray photoelectron spectroscopy was used to confirm the existence of Au–S binding energy at 162.4 eV. Cytotoxicity study revealed that CGNRs were much biocompatible than CTAB-stabilized GNRs. Our results showed that CGNRs functionalized with folic acid (FA) could be internalized by human colon HT-29 cancer cells via folate-mediated endocytosis. From the viability of CGNR-laden HT-29 cells irradiated with 808-nm NIR laser light, we demonstrated that CGNR is a potential photothermal nano-absorber for the ablation of malignant cells under NIR laser exposure.

Vorheriger Artikel Mesoporous silica templated zirconia nanoparticles

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Titel: Gold nanorod stabilized by thiolated chitosan as photothermal absorber for cancer cell treatment
verfasst von: Chung-Hao Wang
Chia-Wei Chang
Ching-An Peng
Publikationsdatum: 01.07.2011
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 7/2011
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-010-0162-5

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