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Journal of Nanoparticle Research

Erschienen in:

01.07.2011 | Research paper

Inhibition effects of protein-conjugated amorphous zinc sulfide nanoparticles on tumor cells growth

verfasst von: Ying Cao, Hua-Jie Wang, Cui Cao, Yuan-Yuan Sun, Lin Yang, Bao-Qing Wang, Jian-Guo Zhou

Erschienen in: Journal of Nanoparticle Research | Ausgabe 7/2011

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Abstract

In this article, a facile and environmentally friendly method was applied to fabricate BSA-conjugated amorphous zinc sulfide (ZnS) nanoparticles using bovine serum albumin (BSA) as the matrix. Transmission electron microscopy analysis indicated that the stable and well-dispersed nanoparticles with the diameter of 15.9 ± 2.1 nm were successfully prepared. The energy dispersive X-ray, X-ray powder diffraction, Fourier transform infrared spectrograph, high resolution transmission electron microscope, and selected area electron diffraction measurements showed that the obtained nanoparticles had the amorphous structure and the coordination occurred between zinc sulfide surfaces and BSA in the nanoparticles. In addition, the inhibition effects of BSA-conjugated amorphous zinc sulfide nanoparticles on tumor cells growth were described in detail by cell viability analysis, optical and electron microscopy methods. The results showed that BSA-conjugated amorphous zinc sulfide nanoparticles could inhibit the metabolism and proliferation of human hepatocellular carcinoma cells, and the inhibition was dose dependent. The half maximal inhibitory concentration (IC50) was 0.36 mg/mL. Overall, this study suggested that BSA-conjugated amorphous zinc sulfide nanoparticles had the application potential as cytostatic agents and BSA in the nanoparticles could provide the modifiable site for the nanoparticles to improve their bioactivity or to endow them with the target function.

Vorheriger Artikel Gold nanorod stabilized by thiolated chitosan as photothermal absorber for cancer cell treatment

Nächster Artikel Sonochemical synthesis and application of rhodium–graphene nanocomposite

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Titel: Inhibition effects of protein-conjugated amorphous zinc sulfide nanoparticles on tumor cells growth
verfasst von: Ying Cao
Hua-Jie Wang
Cui Cao
Yuan-Yuan Sun
Lin Yang
Bao-Qing Wang
Jian-Guo Zhou
Publikationsdatum: 01.07.2011
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 7/2011
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-010-0163-4

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