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2014 | OriginalPaper | Buchkapitel

6. Hyaluronic Acid: A Key Facilitator of Cancer Evolution

verfasst von : Ying Xu, Juan Cui, David Puett

Erschienen in: Cancer Bioinformatics

Verlag: Springer New York

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Abstract

Otto Warburg made a seminal speculation in the 1960s that the switch in cellular energy metabolism from aerobic respiration to glycolytic fermentation is the driving force for cancer development. While increasingly more cancer researchers tend to agree with Warburg, it remains unknown, even five decades after his hypothesis, how this switch is linked to cell proliferation. We have discussed in Chap. 5 how chronic hypoxia and mitochondrial ROS accumulation will lead to continual accumulation of glucose metabolites, possibly resulting in cell death if not removed. This buildup imposes a persistent pressure on the host cells to evolve in order to survive, and cell proliferation represents a most feasible way for these cells to remove the accumulation of metabolites in a sustained manner. We will discuss in this chapter how this pressure can trigger a cellular program to facilitate cell proliferation, hence providing an exit for the accumulated glucose metabolites and a pathway to survival through proliferation.

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Titel: Hyaluronic Acid: A Key Facilitator of Cancer Evolution
verfasst von: Ying Xu
Juan Cui
David Puett
Verlag: Springer New York
Buch: Cancer Bioinformatics
Print ISBN: 978-1-4939-1380-0

Electronic ISBN: 978-1-4939-1381-7

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-1-4939-1381-7_6

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