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2014 | OriginalPaper | Buchkapitel

7. Multiple Routes for Survival: Understanding How Cancer Evades Apoptosis

verfasst von : Ying Xu, Juan Cui, David Puett

Erschienen in: Cancer Bioinformatics

Verlag: Springer New York

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Abstract

Apoptosis is a process of programmed cell-death encoded in all multicellular organisms. The system is designed to remove damaged, unhealthy or unneeded cells during development and under certain stresses. At the tissue level, it plays a key role in maintaining tissue homeostasis. For example, the typical human body produces approximately 50–70 billion new cells by mitosis each day (Karam 2009), and the same number of cells will be terminated by apoptosis to maintain total cell homeostasis, suggesting that there is a functional link between growth and cell death by apoptosis. Malfunctions of the apoptotic system, in either its regulators or effectors, have been linked to a variety of human diseases. Examples include: (1) human degenerative diseases, such as multiple sclerosis, which are known to be associated with abnormally high activities of apoptosis, and (2) cancer that is considered by some as a disease of abnormally low activities of apoptosis.

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Vorheriges Kapitel Hyaluronic Acid: A Key Facilitator of Cancer Evolution

Nächstes Kapitel Cancer Development in Competitive and Hostile Environments

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Titel: Multiple Routes for Survival: Understanding How Cancer Evades Apoptosis
verfasst von: Ying Xu
Juan Cui
David Puett
Verlag: Springer New York
Buch: Cancer Bioinformatics
Print ISBN: 978-1-4939-1380-0

Electronic ISBN: 978-1-4939-1381-7

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-1-4939-1381-7_7

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