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Journal of Materials Science
Erschienen in: Journal of Materials Science 27/2022

08.07.2022 | Materials for life sciences

Injectability study and rheological evaluation of Pluronic-derived thermosensitive hydrogels containing mesoporous bioactive glass nanoparticles for bone regeneration

verfasst von: Priscilla Mol Queiroz, Breno Rocha Barrioni, Jesús Nuncira, Marivalda de Magalhães Pereira

Erschienen in: Journal of Materials Science | Ausgabe 27/2022

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Abstract

Thermosensitive injectable hydrogels are widely investigated as a minimally invasive tool for the delivery of therapeutic agents. Here, Pluronic F-127 hydrogels containing mesoporous bioactive glass nanoparticles were obtained as a novel device to improve bone tissue regeneration. Thermosensitive behavior and injectability of the obtained nanocomposites hydrogels were evaluated, showing feasibility for minimally invasive administration and sol–gel phase transition in the range of 18 to 23 °C, suitable for use as an injectable system. Rheological evaluation showed that adding bioactive glass improved the hydrogel elastic properties and stability at body temperature, also increasing the storage modulus (G’) and residence time. The injectability evaluation showed that all formulations were able to be administrated using a maximum force of up to 2.4 ± 0.4 N, compatible with manual injection. The results shows that Pluronic F-127/mesoporous bioactive glass systems are potential candidates to be applied as injectable systems for therapeutic agents release in situ.
Vorheriger Artikel A hybrid coating of polydopamine and nano-hydroxyapatite enhances surface properties of 3D printed poly(lactic-co-glycolic acid) scaffolds
Nächster Artikel Effect of chromium content on precipitation in Cu–Cr–Zr alloys

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Metadaten
Titel
Injectability study and rheological evaluation of Pluronic-derived thermosensitive hydrogels containing mesoporous bioactive glass nanoparticles for bone regeneration
verfasst von
Priscilla Mol Queiroz
Breno Rocha Barrioni
Jesús Nuncira
Marivalda de Magalhães Pereira
Publikationsdatum
08.07.2022
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 27/2022
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-022-07468-2

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