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Erschienen in:
Application of Neural Network and Finite Element Method for Multiscale Prediction of Bone Fatigue Crack Growth in Cancellous Bone Kapitel lesen Erstes Kapitel lesen

2013 | OriginalPaper | Buchkapitel

Integration of Molecular Signaling into Multiscale Modeling of Cancer

verfasst von : Zhihui Wang, Vittorio Cristini

Erschienen in: Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Verlag: Springer Berlin Heidelberg

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Abstract

Multiscale modeling has now been well-accepted as a powerful tool to quantitatively represent, simulate, understand, and predict cancer progression and development across multiple biological scales. In this chapter, we focus on a specific type of multiscale cancer models where molecular signaling profiles are explicitly linked to the determination of cellular phenotypic changes. These models are particularly suitable for exploring the relationship between signaling dynamics within each individual cancer cell and the emergent cancer behavior on the multicellular level. We also discuss current challenges and future directions of this molecular signaling-incorporated multiscale cancer modeling approach.

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Vorheriges Kapitel Modeling Multiscale Necrotic and Calcified Tissue Biomechanics in Cancer Patients: Application to Ductal Carcinoma In Situ (DCIS)
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Metadaten
Titel
Integration of Molecular Signaling into Multiscale Modeling of Cancer
verfasst von
Zhihui Wang
Vittorio Cristini
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
Buch
Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Print ISBN: 978-3-642-36481-5

Electronic ISBN: 978-3-642-36482-2

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/8415_2012_151

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