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Erschienen in:
Application of Neural Network and Finite Element Method for Multiscale Prediction of Bone Fatigue Crack Growth in Cancellous Bone Kapitel lesen Erstes Kapitel lesen

2013 | OriginalPaper | Buchkapitel

Modeling Multiscale Necrotic and Calcified Tissue Biomechanics in Cancer Patients: Application to Ductal Carcinoma In Situ (DCIS)

verfasst von : Paul Macklin, Shannon Mumenthaler, John Lowengrub

Erschienen in: Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Verlag: Springer Berlin Heidelberg

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Abstract

Tissue necrosis and calcification significantly affect cancer progression and clinical treatment decisions. Necrosis and calcification are inherently multiscale processes, operating at molecular to tissue scales with time scales ranging from hours to months. This chapter details key insights we have gained through mechanistic continuum and discrete multiscale models, including the first modeling of necrotic cell swelling, lysis, and calcification. Among our key findings: necrotic volume loss contributes to steady tumor sizes but can destabilize tumor morphology; steady necrotic fractions can emerge even during unstable growth; necrotic volume loss is responsible for linear ductal carcinoma in situ (DCIS) growth; fast necrotic cell swelling creates mechanical tears at the perinecrotic boundary; multiscale interactions give rise to an age-structured, stratified necrotic core; and mechanistic, patient-calibrated DCIS modeling allows us to assess our working biological assumptions and better interpret pathology and mammography. We finish by outlining our integrative computational oncology approach to developing computational tools that we hope will one day assist clinicians and patients in their treatment decisions.

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Vorheriges Kapitel Wound Healing: Multi-Scale Modeling
Nächstes Kapitel Integration of Molecular Signaling into Multiscale Modeling of Cancer
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Metadaten
Titel
Modeling Multiscale Necrotic and Calcified Tissue Biomechanics in Cancer Patients: Application to Ductal Carcinoma In Situ (DCIS)
verfasst von
Paul Macklin
Shannon Mumenthaler
John Lowengrub
Copyright-Jahr
2013
Verlag
Springer Berlin Heidelberg
Buch
Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Print ISBN: 978-3-642-36481-5

Electronic ISBN: 978-3-642-36482-2

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/8415_2012_150

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