Skip to main content

2019 | OriginalPaper | Buchkapitel

Intermediate Goals in Deep Learning for Retinal Image Analysis

verfasst von : Gilbert Lim, Wynne Hsu, Mong Li Lee

Erschienen in: Computer Vision – ACCV 2018 Workshops

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

End-to-end deep learning has been demonstrated to exhibit human-level performance in many retinal image analysis tasks. However, such models’ generalizability to data from new sources may be less than optimal. We highlight some benefits of introducing intermediate goals in deep learning-based models.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Ting, D.S.W., Pasquale, L.R., Peng, L., et al.: Artificial intelligence and deep learning in ophthalmology. Br. J. Ophthalmol. 103, 167–175 (2018)CrossRef Ting, D.S.W., Pasquale, L.R., Peng, L., et al.: Artificial intelligence and deep learning in ophthalmology. Br. J. Ophthalmol. 103, 167–175 (2018)CrossRef
2.
Zurück zum Zitat Wong, T.Y., Cheung, G.C., Larsen, M., et al.: Diabetic retinopathy. Nat. Rev. Dis. Primers 2 (2016). Article number 16012 Wong, T.Y., Cheung, G.C., Larsen, M., et al.: Diabetic retinopathy. Nat. Rev. Dis. Primers 2 (2016). Article number 16012
3.
Zurück zum Zitat Gulshan, V., Peng, L., Coram, M., et al.: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA 316, 2402–2410 (2016)CrossRef Gulshan, V., Peng, L., Coram, M., et al.: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA 316, 2402–2410 (2016)CrossRef
4.
Zurück zum Zitat Gargeya, R., Leng, T.: Automated identification of diabetic retinopathy using deep learning. Ophthalmology 124, 962–969 (2017)CrossRef Gargeya, R., Leng, T.: Automated identification of diabetic retinopathy using deep learning. Ophthalmology 124, 962–969 (2017)CrossRef
5.
Zurück zum Zitat Burlina, P.M., Joshi, N., Pekala, M., et al.: Automated grading of age-related macular degeneration from color fundus images using deep convolutional neural networks. JAMA Ophthalmol. 135, 1170–1176 (2017)CrossRef Burlina, P.M., Joshi, N., Pekala, M., et al.: Automated grading of age-related macular degeneration from color fundus images using deep convolutional neural networks. JAMA Ophthalmol. 135, 1170–1176 (2017)CrossRef
6.
Zurück zum Zitat Ting, D.S.W., Cheung, C.Y., Lim, G., et al.: Development and validation of a deep learning system for diabetic retinopathy and related eye diseases using retinal images from multiethnic populations with diabetes. JAMA 318, 2211–2223 (2017)CrossRef Ting, D.S.W., Cheung, C.Y., Lim, G., et al.: Development and validation of a deep learning system for diabetic retinopathy and related eye diseases using retinal images from multiethnic populations with diabetes. JAMA 318, 2211–2223 (2017)CrossRef
7.
Zurück zum Zitat Kermany, D.S., Goldbaum, M., Cai, W., et al.: Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172, 1122–1131 (2018)CrossRef Kermany, D.S., Goldbaum, M., Cai, W., et al.: Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172, 1122–1131 (2018)CrossRef
8.
Zurück zum Zitat Bejnordi, B.E., Veta, M., Van Diest, P.J., et al.: Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA 318, 2199–2210 (2017)CrossRef Bejnordi, B.E., Veta, M., Van Diest, P.J., et al.: Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA 318, 2199–2210 (2017)CrossRef
9.
Zurück zum Zitat Esteva, A., Kuprel, B., Novoa, R.A., et al.: Dermatologist-level classification of skin cancer with deep neural networks. Nature 542, 115 (2017)CrossRef Esteva, A., Kuprel, B., Novoa, R.A., et al.: Dermatologist-level classification of skin cancer with deep neural networks. Nature 542, 115 (2017)CrossRef
10.
Zurück zum Zitat Rajpurkar, P., Irvin, J., Zhu, K., et al.: Chexnet: radiologist-level pneumonia detection on chest x-rays with deep learning. arXiv preprint arXiv:1711.05225 (2017) Rajpurkar, P., Irvin, J., Zhu, K., et al.: Chexnet: radiologist-level pneumonia detection on chest x-rays with deep learning. arXiv preprint arXiv:​1711.​05225 (2017)
11.
Zurück zum Zitat Simonyan, K., Vedaldi, A., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. In: Proceedings of the International Conference on Learning Representations (2015) Simonyan, K., Vedaldi, A., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. In: Proceedings of the International Conference on Learning Representations (2015)
12.
Zurück zum Zitat He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016) He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)
13.
Zurück zum Zitat Szegedy, C., Liu, W., Jia, Y., et al.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015) Szegedy, C., Liu, W., Jia, Y., et al.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015)
14.
Zurück zum Zitat Burlina, P., Pacheco, K.D., Joshi, N., et al.: Comparing humans and deep learning performance for grading AMD: a study in using universal deep features and transfer learning for automated AMD analysis. Comput. Biol. Med. 82, 80–86 (2017)CrossRef Burlina, P., Pacheco, K.D., Joshi, N., et al.: Comparing humans and deep learning performance for grading AMD: a study in using universal deep features and transfer learning for automated AMD analysis. Comput. Biol. Med. 82, 80–86 (2017)CrossRef
15.
Zurück zum Zitat Xu, K., Ba, J., Kiros, R., et al.: Show, attend and tell: neural image caption generation with visual attention. In: Proceedings of the International Conference on Machine Learning, pp. 2048–2057 (2015) Xu, K., Ba, J., Kiros, R., et al.: Show, attend and tell: neural image caption generation with visual attention. In: Proceedings of the International Conference on Machine Learning, pp. 2048–2057 (2015)
16.
Zurück zum Zitat Selvaraju, R.R., Cogswell, M., Das, A., et al.: Grad-CAM: visual explanations from deep networks via gradient-based localization. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 618–626 (2017) Selvaraju, R.R., Cogswell, M., Das, A., et al.: Grad-CAM: visual explanations from deep networks via gradient-based localization. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 618–626 (2017)
17.
Zurück zum Zitat van der Maaten, L., Hinton, G.: Visualizing data using t-SNE. J. Mach. Learn. Res. 9, 2579–2605 (2008)MATH van der Maaten, L., Hinton, G.: Visualizing data using t-SNE. J. Mach. Learn. Res. 9, 2579–2605 (2008)MATH
18.
Zurück zum Zitat De Fauw, J., Ledsam, J.R., Romera-Paredes, B., et al.: Clinically applicable deep learning for diagnosis and referral in retinal disease. Nat. Med. 24, 1342 (2018)CrossRef De Fauw, J., Ledsam, J.R., Romera-Paredes, B., et al.: Clinically applicable deep learning for diagnosis and referral in retinal disease. Nat. Med. 24, 1342 (2018)CrossRef
19.
Zurück zum Zitat Sundararajan, M., Taly, A., Yan, Q.: Axiomatic attribution for deep networks. In: Proceedings of the International Conference on Machine Learning, pp. 3319–3328 (2017) Sundararajan, M., Taly, A., Yan, Q.: Axiomatic attribution for deep networks. In: Proceedings of the International Conference on Machine Learning, pp. 3319–3328 (2017)
20.
Zurück zum Zitat Nunes, S., Pires, I., Rosa, A., et al.: Microaneurysm turnover is a biomarker for diabetic retinopathy progression to clinically significant macular edema: findings for type 2 diabetics with nonproliferative retinopathy. Ophthalmologica 223, 292–297 (2009)CrossRef Nunes, S., Pires, I., Rosa, A., et al.: Microaneurysm turnover is a biomarker for diabetic retinopathy progression to clinically significant macular edema: findings for type 2 diabetics with nonproliferative retinopathy. Ophthalmologica 223, 292–297 (2009)CrossRef
21.
Zurück zum Zitat Quellec, G., Lamard, M., Josselin, P.M., et al.: Optimal wavelet transform for the detection of microaneurysms in retina photographs. IEEE Trans. Med. Imaging 27, 1230–1241 (2008)CrossRef Quellec, G., Lamard, M., Josselin, P.M., et al.: Optimal wavelet transform for the detection of microaneurysms in retina photographs. IEEE Trans. Med. Imaging 27, 1230–1241 (2008)CrossRef
22.
Zurück zum Zitat Niemeijer, M., Van Ginneken, B., Cree, M.J., et al.: Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE Trans. Med. Imaging 29, 185–195 (2010)CrossRef Niemeijer, M., Van Ginneken, B., Cree, M.J., et al.: Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE Trans. Med. Imaging 29, 185–195 (2010)CrossRef
23.
Zurück zum Zitat Lim, G., Lee, M.L., Hsu, W., Wong, T.Y.: Transformed representations for convolutional neural networks in diabetic retinopathy screening. In: Proceedings of the AAAI Workshop on Modern Artificial Intelligence for Health Analytics (MAIHA), AAAI, pp. 34–38 (2014) Lim, G., Lee, M.L., Hsu, W., Wong, T.Y.: Transformed representations for convolutional neural networks in diabetic retinopathy screening. In: Proceedings of the AAAI Workshop on Modern Artificial Intelligence for Health Analytics (MAIHA), AAAI, pp. 34–38 (2014)
24.
Zurück zum Zitat Abràmoff, M.D., Lou, Y., Erginay, A., et al.: Improved automated detection of diabetic retinopathy on a publicly available dataset through integration of deep learning. Invest. Ophthalmol. Vis. Sci. 57, 5200–5206 (2016)CrossRef Abràmoff, M.D., Lou, Y., Erginay, A., et al.: Improved automated detection of diabetic retinopathy on a publicly available dataset through integration of deep learning. Invest. Ophthalmol. Vis. Sci. 57, 5200–5206 (2016)CrossRef
25.
Zurück zum Zitat Quellec, G., Charrière, K., Boudi, Y., et al.: Deep image mining for diabetic retinopathy screening. Med. Image Anal. 39, 178–193 (2017)CrossRef Quellec, G., Charrière, K., Boudi, Y., et al.: Deep image mining for diabetic retinopathy screening. Med. Image Anal. 39, 178–193 (2017)CrossRef
26.
Zurück zum Zitat Cheng, J., Liu, J., Xu, Y., et al.: Superpixel classification based optic disc and optic cup segmentation for glaucoma screening. IEEE Trans. Med. Imaging 32, 1019–1032 (2013)CrossRef Cheng, J., Liu, J., Xu, Y., et al.: Superpixel classification based optic disc and optic cup segmentation for glaucoma screening. IEEE Trans. Med. Imaging 32, 1019–1032 (2013)CrossRef
28.
Zurück zum Zitat Lim, G., Cheng, Y., Hsu, W., Lee, M.L.: Integrated optic disc and cup segmentation with deep learning. In: Proceedings of the International Conference on Tools with Artificial Intelligence, pp. 162–169. IEEE (2015) Lim, G., Cheng, Y., Hsu, W., Lee, M.L.: Integrated optic disc and cup segmentation with deep learning. In: Proceedings of the International Conference on Tools with Artificial Intelligence, pp. 162–169. IEEE (2015)
29.
Zurück zum Zitat Burlina, P.M., Joshi, N., Pacheco, K.D., et al.: Use of deep learning for detailed severity characterization and estimation of 5-year risk among patients with age-related macular degeneration. JAMA Ophthalmol. 136, 1359–1366 (2018)CrossRef Burlina, P.M., Joshi, N., Pacheco, K.D., et al.: Use of deep learning for detailed severity characterization and estimation of 5-year risk among patients with age-related macular degeneration. JAMA Ophthalmol. 136, 1359–1366 (2018)CrossRef
30.
Zurück zum Zitat Niemeijer, M., Staal, J., van Ginneken, B., et al.: Comparative study of retinal vessel segmentation methods on a new publicly available database. In: Proceedings of Medical Imaging 2004: Image Processing, vol. 5370, pp. 648–657. International Society for Optics and Photonics (2004) Niemeijer, M., Staal, J., van Ginneken, B., et al.: Comparative study of retinal vessel segmentation methods on a new publicly available database. In: Proceedings of Medical Imaging 2004: Image Processing, vol. 5370, pp. 648–657. International Society for Optics and Photonics (2004)
31.
Zurück zum Zitat Abràmoff, M.D., Lavin, P.T., Birch, M., et al.: Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices. npj Digit. Med. 1, 39 (2018)CrossRef Abràmoff, M.D., Lavin, P.T., Birch, M., et al.: Pivotal trial of an autonomous AI-based diagnostic system for detection of diabetic retinopathy in primary care offices. npj Digit. Med. 1, 39 (2018)CrossRef
32.
Zurück zum Zitat Poplin, R., Varadarajan, A.V., Blumer, K., et al.: Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. Nat. Biomed. Eng. 2, 158 (2018)CrossRef Poplin, R., Varadarajan, A.V., Blumer, K., et al.: Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning. Nat. Biomed. Eng. 2, 158 (2018)CrossRef
33.
Zurück zum Zitat Lim, G., Lim, Z.W., Xu, D., et al.: Feature isolation for hypothesis testing in retinal imaging: an ischemic stroke prediction case study. In: Proceedings of the Innovative Applications of Artificial Intelligence Conference (2019) Lim, G., Lim, Z.W., Xu, D., et al.: Feature isolation for hypothesis testing in retinal imaging: an ischemic stroke prediction case study. In: Proceedings of the Innovative Applications of Artificial Intelligence Conference (2019)
Metadaten
Titel
Intermediate Goals in Deep Learning for Retinal Image Analysis
verfasst von
Gilbert Lim
Wynne Hsu
Mong Li Lee
Copyright-Jahr
2019
DOI
https://doi.org/10.1007/978-3-030-21074-8_22

Premium Partner