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Journal of Nanoparticle Research
Erschienen in: Journal of Nanoparticle Research 5/2013

01.05.2013 | Research Paper

Intranasal delivery of nanoparticle-based vaccine increases protection against S. pneumoniae

verfasst von: Brittney Mott, Sanjay Thamake, Jamboor Vishwanatha, Harlan P. Jones

Erschienen in: Journal of Nanoparticle Research | Ausgabe 5/2013

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Abstract

Nanoparticle (NP) technologies are becoming commonplace in the development of vaccine delivery systems to protect against various diseases. The current study determined the efficacy of intranasal delivery of a 234 ± 87.5 nm poly lactic-co-glycolic acid nanoparticle vaccine construct in establishing protection against experimental respiratory pneumococcal infection. Nanoparticles encapsulating heat-killed Streptococcus pneumoniae (NP-HKSP) were retained in the lungs 11 days following nasal administration compared to empty NP. Immunization with NP-HKSP produced significant resistance against S. pneumoniae infection compared to administration of HKSP alone. Increased protection correlated with a significant increase in antigen-specific Th1-associated IFN-γ cytokine response by pulmonary lymphocytes. This study establishes the efficacy of NP-based technology as a non-invasive and targeted approach for nasal-pulmonary immunization against pulmonary infections.
Vorheriger Artikel Direct evidence of advantage of using nanosized zeolite Beta for ISFET-based biosensor construction
Nächster Artikel Manipulation of half-metallicity and ferromagnetism in N-doped CdS nanowire

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Metadaten
Titel
Intranasal delivery of nanoparticle-based vaccine increases protection against S. pneumoniae
verfasst von
Brittney Mott
Sanjay Thamake
Jamboor Vishwanatha
Harlan P. Jones
Publikationsdatum
01.05.2013
Verlag
Springer Netherlands
Erschienen in
Journal of Nanoparticle Research / Ausgabe 5/2013
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-013-1646-x

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