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2019 | OriginalPaper | Buchkapitel

Ionic Liquids in Bioseparation Processes

verfasst von : Diana C. V. Belchior, Iola F. Duarte, Mara G. Freire

Erschienen in: Application of Ionic Liquids in Biotechnology

Verlag: Springer International Publishing

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Abstract

Bioseparation processes are a relevant part of modern biotechnology, particularly regarding the development of efficient and biocompatible methods for the separation and purification of added-value biologically active compounds. In this field, ionic liquids (ILs) have been proposed, either in liquid–liquid extractions, in which non-water miscible ILs or aqueous biphasic systems (ABS) formed by ILs can be used, or in solid–liquid extractions, in which they are covalently attached to create supported IL phases (SILPs). Aprotic ILs possess unique properties, such as non-volatility and designability, which are valuable in their use in bioseparation processes. In this chapter, we summarize and discuss bioseparation processes based on ILs, including both liquid–liquid and solid–liquid extractions, applied to amino acids and proteins. The most recent and remarkable advances in this area are emphasized, and improvements brought by the use of ILs properly discussed. New insights and envisaged directions with IL-based bioseparation processes are suggested.

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Nächstes Kapitel Natural Deep Eutectic Solvents and Their Applications in Biotechnology

Martínez-Aragón M, Burghoff S, Goetheer ELV, de Haan AB (2009) Guidelines for solvent selection for carrier mediated extraction of proteins. Sep Purif Technol 65:65–72. https://doi.org/10.1016/j.seppur.2008.01.028 CrossRef

Ahamed T, Ottens M, Nfor BK et al (2006) A generalized approach to thermodynamic properties of biomolecules for use in bioseparation process design. Fluid Phase Equilib 241:268–282. https://doi.org/10.1016/j.fluid.2005.12.011 CrossRef

Bhawsar CM, Pandit B, Sawant B, Joshi B (1994) Enzyme mass transfer coefficient in a sieve plate extraction column. Chem Eng J 55:B1–B17. https://doi.org/10.1016/0923-0467(94)87012-8 CrossRef

Ventura SPM, Silva FA, Quental MV et al (2017) Ionic-liquid-mediated extraction and separation processes for bioactive compounds: past, present, and future trends. Chem Rev 117:6984–7052. https://doi.org/10.1021/acs.chemrev.6b00550 CrossRefPubMedPubMedCentral

Plechkova NV, Seddon KR (2008) Applications of ionic liquids in the chemical industry. Chem Soc Rev 37:123–150. https://doi.org/10.1039/B006677J CrossRefPubMed

Albertsson P (1986) Partition of cell particles and macromolecules: separation and purification of biomolecules, cell organelles, membranes, and cells in aqueous polymer two-phase systems and their use in biochemical analysis and biotechnology.3rd edn. Wiley, Chichester

Iqbal M, Tao Y, Xie S et al (2016) Aqueous two-phase system (ATPS): an overview and advances in its applications. Biol Proced Online 18:1–18. https://doi.org/10.1186/s12575-016-0048-8 CrossRef

Grilo AL, Aires-Barros MR, Azevedo AM (2014) Partitioning in aqueous two-phase systems: fundamentals, applications and trends. Sep Purif Rev 45:68–80. https://doi.org/10.1080/15422119.2014.983128 CrossRef

Azevedo AM, Fonseca LP, Prazeres DMF (1999) Stability and stabilisation of penicillin acylase. J Chem Technol Biotechnol 74:1110–1116. https://doi.org/10.1002/(SICI)1097-4660(199911)74:11<1110::AID-JCTB149>3.0.CO;2-B CrossRef

10.

Pereira JFB, Rebelo LPN, Rogers RD et al (2013) Combining ionic liquids and polyethylene glycols to boost the hydrophobic-hydrophilic range of aqueous biphasic systems. Phys Chem Chem Phys 15:19580–19583. https://doi.org/10.1039/c3cp53701c CrossRefPubMed

11.

Li J, Kao WJ (2003) Synthesis of polyethylene glycol (PEG) derivatives and PEGylated - peptide biopolymer conjugates. Biomacromolecules 4:1055–1067. https://doi.org/10.1021/bm034069l CrossRefPubMed

12.

Rosa PAJ, Azevedo AM, Ferreira IF et al (2007) Affinity partitioning of human antibodies in aqueous two-phase systems. J Chromatogr A 1162:103–113. https://doi.org/10.1016/j.chroma.2007.03.067 CrossRefPubMed

13.

Pereira JFB, Lima ÁS, Freire MG, Coutinho JAP (2010) Ionic liquids as adjuvants for the tailored extraction of biomolecules in aqueous biphasic systems. Green Chem 12:1661. https://doi.org/10.1039/c003578e CrossRef

14.

Dhadge VL, Rosa SASL, Azevedo AM et al (2014) Magnetic aqueous two-phase fishing: a hybrid process technology for antibody purification. J Chromatogr A 1339:59–64. https://doi.org/10.1016/j.chroma.2014.02.069 CrossRefPubMed

15.

Gutowski KE, Broker GA, Willauer HD et al (2003) Controlling the aqueous miscibility of ionic liquids: aqueous biphasic systems of water-miscible ionic liquids and water-structuring salts for recycle, metathesis, and separations. J Am Chem Soc 125:6632–6633. https://doi.org/10.1021/ja0351802 CrossRefPubMed

16.

Freire MG, Cláudio AFM, Araújo JMM et al (2012) Aqueous biphasic systems: a boost brought about by using ionic liquids. Chem Soc Rev 41:4966–4995. https://doi.org/10.1039/c2cs35151j CrossRefPubMed

17.

Abd A, Ahmed A, Xiashi Z (2017) Developments/application of ionic liquids/poly ionic liquids in magnetic solid-phase extraction and solid phase microextraction. Colloid Surf Sci 2:162–170. https://doi.org/10.11648/j.css.20170204.15 CrossRef

18.

Carda-Broch S, Berthod A, Armstrong DW (2003) Solvent properties of the 1-butyl-3-methylimidazolium hexafluorophosphate ionic liquid. Anal Bioanal Chem 375:191–199. https://doi.org/10.1007/s00216-002-1684-1 CrossRefPubMed

19.

Smirnova SV, Torocheshnikova II, Formanovsky AA, Pletnev IV (2004) Solvent extraction of amino acids into a room temperature ionic liquid with dicyclohexano-18-crown-6. Anal Bioanal Chem 378:1369–1375. https://doi.org/10.1007/s00216-003-2398-8 CrossRefPubMed

20.

Wang J, Pei Y, Zhao Y, Hu Z (2005) Recovery of amino acids by imidazolium based ionic liquids from aqueous media. Green Chem 7:196–202. https://doi.org/10.1039/b415842c CrossRef

21.

Absalan G, Akhond M, Sheikhian L (2010) Partitioning of acidic, basic and neutral amino acids into imidazolium-based ionic liquids. Amino Acids 39:167–174. https://doi.org/10.1007/s00726-009-0391-z CrossRefPubMed

22.

Tomé LIN, Catambas VR, Teles ARR et al (2010) Tryptophan extraction using hydrophobic ionic liquids. Sep Purif Technol 72:167–173. https://doi.org/10.1016/j.seppur.2010.02.002 CrossRef

23.

Huaxi L, Zhuo L, Jingmei Y et al (2012) Liquid–liquid extraction process of amino acids by a new amide-based functionalized ionic liquid. Green Chem 14:172–1727. https://doi.org/10.1039/c2gc16560k CrossRef

24.

Tang F, Zhang Q, Ren D et al (2010) Functional amino acid ionic liquids as solvent and selector in chiral extraction. J Chromatogr A 1217:4669–4674. https://doi.org/10.1016/j.chroma.2010.05.013 CrossRefPubMed

25.

Shimojo K, Kamiya N, Tani F et al (2006) Functional conversion of cytochrome c in ionic liquids via crown ether Complexation. Anal Chem 78:7735–7742. https://doi.org/10.1021/ac0612877 CrossRefPubMed

26.

Tzeng YP, Shen CW, Yu T (2008) Liquid-liquid extraction of lysozyme using a dye-modified ionic liquid. J Chromatogr A 1193:1–6. https://doi.org/10.1016/j.chroma.2008.02.118 CrossRefPubMed

27.

Kohno Y, Saita S, Murata K et al (2011) Extraction of proteins with temperature sensitive and reversible phase change of ionic liquid/water mixture. Polym Chem 2:862–867. https://doi.org/10.1039/c0py00364f CrossRef

28.

Ito Y, Kohno Y, Nakamura N, Ohno H (2013) Design of phosphonium-type zwitterion as an additive to improve saturated water content of phase-separated ionic liquid from aqueous phase toward reversible extraction of proteins. Int J Mol Sci 14:18350–18361. https://doi.org/10.3390/ijms140918350 CrossRefPubMedPubMedCentral

29.

Xu W, Cao H, Ren G et al (2014) An AIL/IL-based liquid/liquid extraction system for the purification of His-tagged proteins. Appl Microbiol Biotechnol 98:5665–5675. https://doi.org/10.1007/s00253-014-5737-0 CrossRefPubMed

30.

Ren G, Gong X, Wang B et al (2015) Affinity ionic liquids for the rapid liquid-liquid extraction purification of hexahistidine tagged proteins. Sep Purif Technol 146:114–120. https://doi.org/10.1016/j.seppur.2015.03.025 CrossRef

31.

Cheng DH, Chen XW, Shu Y, Wang JH (2008) Selective extraction/isolation of hemoglobin with ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate (BtmsimPF6). Talanta 75:1270–1278. https://doi.org/10.1016/j.talanta.2008.01.044 CrossRefPubMed

32.

Cheng D-H, Chen X-W, Shu Y, Wang J-H (2008) Extraction of cytochrome C by ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate. Chinese J Anal Chem 36:1187–1190. https://doi.org/10.1016/S1872-2040(08)60066-3 CrossRef

33.

Huh YS, Jeong CM, Chang HN et al (2010) Rapid separation of bacteriorhodopsin using a laminar-flow extraction system in a microfluidic device. Biomicrofluidics 4:14103(10)–14103(1). https://doi.org/10.1063/1.3298608 CrossRef

34.

Alvarez-Guerra E, Irabien A (2012) Extraction of lactoferrin with hydrophobic ionic liquids. Sep Purif Technol 98:432–440. https://doi.org/10.1016/j.seppur.2012.08.010 CrossRef

35.

Ventura PM, Neves CMSS, Freire MG et al (2009) Evaluation of anion influence on the formation and extraction capability of ionic-liquid-based aqueous biphasic systems. J Phys Chem B 113:9304–9310. https://doi.org/10.1021/jp900293v CrossRefPubMed

36.

Neves CMSS, Ventura SPM, Freire MG et al (2009) Evaluation of cation influence on the formation and extraction capability of ionic-liquid-based aqueous biphasic systems. J Phys Chem B 113:5194–5199. https://doi.org/10.1021/jp900293v CrossRefPubMed

37.

Li Z, Pei Y, Liu L, Wang J (2010) (Liquid+liquid) equilibria for (acetate-based ionic liquids + inorganic salts) aqueous two-phase systems. J Chem Thermodyn 42:932–937. https://doi.org/10.1016/j.jct.2010.03.010 CrossRef

38.

Pei Y, Li Z, Liu L, Wang J (2012) Partitioning behavior of amino acids in aqueous two-phase systems formed by imidazolium ionic liquid and dipotassium hydrogen phosphate. J Chromatogr A 1231:2–7. https://doi.org/10.1016/j.chroma.2012.01.087 CrossRefPubMed

39.

Louros CLS, Claudio AFM, Neves CMSS et al (2010) Extraction of biomolecules using phosphonium-based ionic liquids + K₃PO₄ aqueous biphasic systems. Int J Mol Sci 11:1777–1791. https://doi.org/10.3390/ijms11041777 CrossRefPubMedPubMedCentral

40.

Zafarani-Moattar MT, Hamzehzadeh S (2011) Partitioning of amino acids in the aqueous biphasic system containing the water-miscible ionic liquid 1-butyl-3-methylimidazolium bromide and the water-structuring salt potassium citrate. Biotechnol Prog 27:986–997. https://doi.org/10.1002/btpr.613 CrossRefPubMed

41.

Passos H, Ferreira AR, Cláudio AFM et al (2012) Characterization of aqueous biphasic systems composed of ionic liquids and a citrate-based biodegradable salt. Biochem Eng J 67:68–76. https://doi.org/10.1016/j.bej.2012.05.004 CrossRef

42.

Wu D, Zhou Y, Cai P et al (2015) Specific cooperative effect for the enantiomeric separation of amino acids using aqueous two-phase systems with task-specific ionic liquids. J Chromatogr A 1395:65–72. https://doi.org/10.1016/j.chroma.2015.03.047 CrossRefPubMed

43.

Salabat A, Abnosi MH, Motahari A (2008) Investigation of amino acid partitioning in aqueous two-phase systems containing polyethylene glycol and inorganic salts. J Chem Eng Data 53:2018–2021. https://doi.org/10.1021/je700727u CrossRef

44.

Zafarani-Moattar MT, Hamzehzadeh S, Nasiri S (2011) A new aqueous biphasic system containing polypropylene glycol and a water-miscible ionic liquid. Biotechnol Prog 28:146–156. https://doi.org/10.1002/btpr.718 CrossRefPubMed

45.

Xie Y, Xing H, Yang Q et al (2015) Aqueous biphasic system containing long chain anion-functionalized ionic liquids for high-performance extraction. ACS Sustain Chem Eng 3:3365–3372. https://doi.org/10.1021/acssuschemeng.5b01068 CrossRef

46.

Freire MG, Louros CLS, Rebelo LPN, Coutinho JAP (2011) Aqueous biphasic systems composed of a water-stable ionic liquid + carbohydrates and their applications. Green Chem 13:1536–1545. https://doi.org/10.1039/c1gc15110j CrossRef

47.

Luis A, Dinis TBV, Passos H et al (2015) Good’s buffers as novel phase-forming components of ionic-liquid-based aqueous biphasic systems. Biochem Eng J 101:142–149. https://doi.org/10.1016/j.bej.2015.05.008 CrossRefPubMedPubMedCentral

48.

Capela EV, Quental MV, Domingues P et al (2017) Effective separation of aromatic and aliphatic amino acid mixtures using ionic-liquid-based aqueous biphasic systems. Green Chem 19:1850–1854. https://doi.org/10.1039/C6GC03060B CrossRefPubMedPubMedCentral

49.

Hamzehzadeh S, Vasiresh M (2014) Ionic liquid 1-butyl-3-methylimidazolium bromide as a promoter for the formation and extraction capability of poly(ethylene glycol)-potassium citrate aqueous biphasic system at T=298.15K. Fluid Phase Equilib 382:80–88. https://doi.org/10.1016/j.fluid.2014.08.029 CrossRef

50.

Lu Y, Lu W, Wang W et al (2011) Thermodynamic studies of partitioning behavior of cytochrome c in ionic liquid-based aqueous two-phase system. Talanta 85:1621–1626. https://doi.org/10.1016/j.talanta.2011.06.058 CrossRefPubMed

51.

Dreyer S, Salim P, Kragl U (2009) Driving forces of protein partitioning in an ionic liquid-based aqueous two-phase system. Biochem Eng J 46:176–185. https://doi.org/10.1016/j.bej.2009.05.005 CrossRef

52.

Pei Y, Li L, Li Z et al (2012) Partitioning behavior of wastewater proteins in some ionic liquids-based aqueous two-phase systems. Sep Sci Technol 47:277–283. https://doi.org/10.1080/01496395.2011.609241 CrossRef

53.

Yan H, Wu J, Dai G et al (2012) Interaction mechanisms of ionic liquids [Cnmim]Br (n = 4, 6, 8, 10) with bovine serum albumin. J Lumin 132:622–628. https://doi.org/10.1016/j.jlumin.2011.10.026 CrossRef

54.

Lin X, Wang Y, Zeng Q et al (2013) Extraction and separation of proteins by ionic liquid aqueous two-phase system. Analyst 138:6445–6453. https://doi.org/10.1039/c3an01301d CrossRefPubMed

55.

Pei Y, Li Z, Liu L et al (2010) Selective separation of protein and saccharides by ionic liquids aqueous two-phase systems. Sci China Chem 53:1554–1560. https://doi.org/10.1007/s11426-010-4025-9 CrossRef

56.

Sheikhian L, Akhond M, Absalan G, Goltz DM (2013) Dye-affinity partitioning of acidic, basic, and neutral proteins in ionic liquid-based aqueous biphasic systems. Sep Sci Technol 48:2372–2380. https://doi.org/10.1080/01496395.2013.804086 CrossRef

57.

Chen J, Wang Y, Zeng Q et al (2014) Partition of proteins with extraction in aqueous two-phase system by hydroxyl ammonium-based ionic liquid. Anal Methods 6:4067–4076. https://doi.org/10.1039/c4ay00233d CrossRef

58.

Bisht M, Kumar A, Venkatesu P (2015) Analysis of the driving force that rule the stability of lysozyme in alkylammonium-based ionic liquids. Int J Biol Macromol 81:1074–1081. https://doi.org/10.1016/j.ijbiomac.2015.09.036 CrossRefPubMed

59.

Santos JHPM, E Silva FA, Coutinho JAP et al (2015) Ionic liquids as a novel class of electrolytes in polymeric aqueous biphasic systems. Process Biochem 50:661–668. https://doi.org/10.1016/j.procbio.2015.02.001 CrossRef

60.

Wu C, Wang J, Li Z et al (2013) Relative hydrophobicity between the phases and partition of cytochrome-c in glycine ionic liquids aqueous two-phase systems. J Chromatogr A 1305:1–6. https://doi.org/10.1016/j.chroma.2013.06.066 CrossRefPubMed

61.

Huang S, Wang Y, Zhou Y et al (2013) Choline-like ionic liquid-based aqueous two-phase extraction of selected proteins. Anal Methods 5:3395–3402. https://doi.org/10.1016/B978-1-895198-85-0.50012-1 CrossRef

62.

Li Z, Liu X, Pei Y et al (2012) Design of environmentally friendly ionic liquid aqueous two-phase systems for the efficient and high activity extraction of proteins. Green Chem 14:2941. https://doi.org/10.1039/c2gc35890e CrossRef

63.

Taha M, Quental MV, Correia I et al (2015) Extraction and stability of bovine serum albumin (BSA) using cholinium-based Good’s buffers ionic liquids. Process Biochem 50:1158–1166. https://doi.org/10.1016/j.procbio.2015.03.020 CrossRefPubMedPubMedCentral

64.

Quental MV, Caban M, Pereira MM et al (2015) Enhanced extraction of proteins using cholinium-based ionic liquids as phase-forming components of aqueous biphasic systems. Biotechnol J 10:1457–1466. https://doi.org/10.1002/biot.201500003 CrossRefPubMed

65.

Song CP, Ramanan RN, Vijayaraghavan R et al (2015) Aqueous two-phase systems based on cholinium aminoate ionic liquids with tunable hydrophobicity and charge density. ACS Sustain Chem Eng 3:3291–3298. https://doi.org/10.1021/acssuschemeng.5b00881 CrossRef

66.

Taha M, e Silva FA, Quental MV et al (2014) Good’s buffers as a basis for developing self-buffering and biocompatible ionic liquids for biological research. Green Chem 16:3149–3159. https://doi.org/10.1039/C4GC00328D CrossRefPubMedPubMedCentral

67.

Passos H, Luís A, Coutinho JAP, Freire MG (2016) Thermoreversible (ionic-liquid- based) aqueous biphasic systems. Sci Rep 6:1–7. https://doi.org/10.1038/srep20276 CrossRef

68.

Taha M, Almeida MR, Francisca A, Domingues P (2015) Novel biocompatible and self-buffering ionic liquids for biopharmaceutical applications. Chem Eur J 21:4781–4788. https://doi.org/10.1002/chem.201405693 CrossRefPubMed

69.

Ferreira AM, Faustino VFM, Mondal D et al (2016) Improving the extraction and purification of immunoglobulin G by the use of ionic liquids as adjuvants in aqueous biphasic systems. J Biotechnol 236:166–175. https://doi.org/10.1016/j.jbiotec.2016.08.015 CrossRefPubMedPubMedCentral

70.

Ramalho CC, Neves CMSS, Quental MV et al (2018) Separation of immunoglobulin G using aqueous biphasic systems composed of cholinium-based ionic liquids and poly(propylene glycol). J Chem Technol Biotechnol. https://doi.org/10.1002/jctb.5594 CrossRef

71.

Mondal D, Sharma M, Quental MV et al (2016) Suitability of bio-based ionic liquids for the extraction and purification of IgG antibodies. Green Chem 18:6071–6081. https://doi.org/10.1039/C6GC01482H CrossRefPubMedPubMedCentral

72.

Desai RK, Streefland M, Wijffels RH, Eppink MHM (2014) Extraction and stability of selected proteins in ionic liquid based aqueous two-phase systems. Green Chem 16:2670–2679. https://doi.org/10.1039/C3GC42631A CrossRef

73.

Tan ZJ, Li FF, Xu XL, Xing JM (2012) Simultaneous extraction and purification of aloe poly saccharides and proteins using ionic liquid based aqueous two-phase system coupled with dialysis membrane. Desalination 286:389–393. https://doi.org/10.1016/j.desal.2011.11.053 CrossRef

74.

Yan JK, Ma HL, Pei JJ et al (2014) Facile and effective separation of polysaccharides and proteins from Cordyceps sinensis mycelia by ionic liquid aqueous two-phase system. Sep Purif Technol 135:278–284. https://doi.org/10.1016/j.seppur.2014.03.020 CrossRef

75.

Pereira MM, Pedro SN, Quental MV et al (2015) Enhanced extraction of bovine serum albumin with aqueous biphasic systems of phosphonium- and ammonium-based ionic liquids. J Biotechnol 206:17–25. https://doi.org/10.1016/j.jbiotec.2015.03.028 CrossRefPubMedPubMedCentral

76.

Deive FJ, Rodríguez A, Pereiro AB et al (2011) Ionic liquid-based aqueous biphasic system for lipase extraction. Green Chem 13:390–396. https://doi.org/10.1039/C0GC00075B CrossRef

77.

Deive FJ, Rodríguez A, Rebelo LPN, Marrucho IM (2012) Extraction of Candida antarctica lipase A from aqueous solutions using imidazolium-based ionic liquids. Sep Purif Technol 97:205–210. https://doi.org/10.1016/j.seppur.2011.12.013 CrossRef

78.

Ventura SPM, Sousa SG, Freire MG et al (2011) Design of ionic liquids for lipase purification. J Chromatogr B Anal Technol Biomed Life Sci 879:2679–2687. https://doi.org/10.1016/j.jchromb.2011.07.022 CrossRef

79.

Ventura SPM, de Barros RLF, de Pinho Barbosa JM et al (2012) Production and purification of an extracellular lipolytic enzyme using ionic liquid-based aqueous two-phase systems. Green Chem 14:734–740. https://doi.org/10.1039/c2gc16428k CrossRef

80.

Souza RL, Ventura SPM, Soares CMF et al (2015) Lipase purification using ionic liquids as adjuvants in aqueous two-phase systems. Green Chem 17:3026–3034. https://doi.org/10.1039/C5GC00262A CrossRef

81.

Souza RL, Lima RA, Coutinho JAP et al (2015) Aqueous two-phase systems based on cholinium salts and tetrahydrofuran and their use for lipase purification. Sep Purif Technol 155:118–126. https://doi.org/10.1016/j.seppur.2015.05.021 CrossRef

82.

Lee SY, Khoiroh I, Coutinho JAP et al (2017) Lipase production and purification by self-buffering ionic liquid-based aqueous biphasic systems. Process Biochem 63:221–228. https://doi.org/10.1016/j.procbio.2017.08.020 CrossRef

83.

Bai Z, Chao Y, Zhang M et al (2013) Partitioning behavior of papain in ionic liquids-based aqueous two-phase systems. J Chem 2013:1–6. https://doi.org/10.1155/2013/938154 CrossRef

84.

Cao Q, Quan L, He C et al (2008) Talanta partition of horseradish peroxidase with maintained activity in aqueous biphasic system based on ionic liquid. Talanta 77:160–165. https://doi.org/10.1016/j.talanta.2008.05.055 CrossRefPubMed

85.

Simental-Martínez J, Rito-Palomares M, Benavides J (2014) Potential application of aqueous two-phase systems and three-phase partitioning for the recovery of superoxide dismutase from a clarified homogenate of Kluyveromyces marxianus. Biotechnol Prog 30:1326–1334. https://doi.org/10.1002/btpr.1979 CrossRefPubMed

86.

Santos JHPM, Santos JC et al (2018) In situ purification of periplasmatic L-asparaginase by aqueous two phase systems with ionic liquids (ILs) as adjuvants. J Chem Technol Biotechnol. https://doi.org/10.1002/jctb.5455 CrossRef

87.

Jiang B, Feng Z, Liu C et al (2015) Extraction and purification of wheat-esterase using aqueous two-phase systems of ionic liquid and salt. J Food Sci Technol 52:2878–2885. https://doi.org/10.1007/s13197-014-1319-5 CrossRefPubMed

88.

Novak U, Pohar A, Plazl I, Žnidaršič-Plazl P (2012) Ionic liquid-based aqueous two-phase extraction within a microchannel system. Sep Purif Technol 97:172–178. https://doi.org/10.1016/j.seppur.2012.01.033 CrossRef

89.

Vidal L, Riekkola ML, Canals A (2012) Ionic liquid-modified materials for solid-phase extraction and separation: a review. Anal Chim Acta 715:19–41. https://doi.org/10.1016/j.aca.2011.11.050 CrossRefPubMed

90.

Fumes BH, Silva MR, Andrade FN et al (2015) Recent advances and future trends in new materials for sample preparation. TrAC Trends Anal Chem 71:9–25. https://doi.org/10.1016/j.trac.2015.04.011 CrossRef

91.

Marwani HM, Bakhsh EM, Al-Turaif HA et al (2014) Enantioselective separation and detection of D-phenylalanine based on newly developed chiral ionic liquid immobilized silica gel surface. Int J Electrochem Sci 9:7948–7964

92.

Yang L, Hu X, Guan P et al (2015) Molecularly imprinted polymers for the selective recognition of L-phenylalanine based on 1-buty-3-methylimidazolium ionic liquid. J Appl Polym Sci 132:42485(1)–42485(9). https://doi.org/10.1002/app.42485 CrossRef

93.

Shu Y, Chen XW, Wang JH (2010) Ionic liquid-polyvinyl chloride ionomer for highly selective isolation of basic proteins. Talanta 81:637–642. https://doi.org/10.1016/j.talanta.2009.12.059 CrossRefPubMed

94.

Zhao G, Chen S, Chen XW, He RH (2013) Selective isolation of hemoglobin by use of imidazolium-modified polystyrene as extractant. Anal Bioanal Chem 405:5353–5358. https://doi.org/10.1007/s00216-013-6889-y CrossRefPubMed

95.

Liu Y, Ma R, Deng Q et al (2014) Preparation of ionic liquid polymer materials and their recognition properties for proteins. RSC Adv 4:52147–52154. https://doi.org/10.1039/C4RA05713A CrossRef

96.

Chen J, Wang Y, Ding X et al (2014) Magnetic solid-phase extraction of proteins based on hydroxy functional ionic liquid-modified magnetic nanoparticles. Anal Methods 6:8358–8367. https://doi.org/10.1039/C4AY01786B CrossRef

97.

Wen Q, Wang Y, Xu K et al (2016) Magnetic solid-phase extraction of protein by ionic liquid-coated Fe@graphene oxide. Talanta 160:481–488. https://doi.org/10.1016/j.talanta.2016.07.031 CrossRefPubMed

Titel: Ionic Liquids in Bioseparation Processes
verfasst von: Diana C. V. Belchior
Iola F. Duarte
Mara G. Freire
Verlag: Springer International Publishing
Buch: Application of Ionic Liquids in Biotechnology
Print ISBN: 978-3-030-23080-7

Electronic ISBN: 978-3-030-23081-4

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/10_2018_66

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