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Journal of Nanoparticle Research

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01.10.2017 | Research Paper

Iron oxide nanoparticles with different polymer coatings for photothermal therapy

verfasst von: Jia Yang, Lu Fan, Yanhong Xu, Jindong Xia

Erschienen in: Journal of Nanoparticle Research | Ausgabe 10/2017

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Abstract

Iron oxide nanoparticles (Fe₃O₄ NPs) have attracted significant attention in view of their potential applications in biomedicine. Surface coatings or modifications are generally needed to improve the colloidal stability of Fe₃O₄ NPs in a physiological environment. In this study, Fe₃O₄ NPs in the size range of 12–15 nm coated with polyacrylic acid (PAA), poly(vinyl alcohol) (PVA), and polyethyleneimine (PEI) were synthesized through a mild reduction route to investigate their potential for photothermal therapy. The polymer-coated Fe₃O₄ NPs dispersed well in water and formed stable colloids; the surface charges of the particles were dependent on the nature of the surface coating. The strong absorption in the near-infrared (NIR) region enabled the coated Fe₃O₄ NPs to be used as agents in photothermal therapy. The photothermal conversion efficiency of PEI-coated Fe₃O₄ NPs (PEI-Fe₃O₄ NPs) distinctly decreased when exposed to a cell culture medium. In addition, PEI-Fe₃O₄ NPs showed higher cytotoxicity and enhanced cellular uptake efficiency when compared to PAA-coated Fe₃O₄ NPs (PAA-Fe₃O₄ NPs) and PVA-coated Fe₃O₄ NPs (PVA-Fe₃O₄ NPs). This study highlights the importance of optimizing the surface properties of Fe₃O₄ NPs when using them in biomedical applications and provides guidelines for the design and development of functional Fe₃O₄ NPs for cancer therapy.

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Titel: Iron oxide nanoparticles with different polymer coatings for photothermal therapy
verfasst von: Jia Yang
Lu Fan
Yanhong Xu
Jindong Xia
Publikationsdatum: 01.10.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 10/2017
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-4031-3

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