Skip to main content
Erschienen in: International Journal of Computer Assisted Radiology and Surgery 6/2021

08.05.2021 | Original Article

Joint optic disc and optic cup segmentation based on boundary prior and adversarial learning

verfasst von: Ling Luo, Dingyu Xue, Feng Pan, Xinglong Feng

Erschienen in: International Journal of Computer Assisted Radiology and Surgery | Ausgabe 6/2021

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Purpose

The most direct means of glaucoma screening is to use cup-to-disc ratio via colour fundus photography, the first step of which is the precise segmentation of the optic cup (OC) and optic disc (OD). In recent years, convolution neural networks (CNN) have shown outstanding performance in medical segmentation tasks. However, most CNN-based methods ignore the effect of boundary ambiguity on performance, which leads to low generalization. This paper is dedicated to solving this issue.

Methods

In this paper, we propose a novel segmentation architecture, called BGA-Net, which introduces an auxiliary boundary branch and adversarial learning to jointly segment OD and OC in a multi-label manner. To generate more accurate results, the generative adversarial network is exploited to encourage boundary and mask predictions to be similar to the ground truth ones.

Results

Experimental results show that our BGA-Net system achieves state-of-the-art OC and OD segmentation performance on three publicly available datasets, i.e., the Dice scores for the optic disc/cup on the Drishti-GS, RIM-ONE-r3 and REFUGE datasets are 0.975/0.898, 0.967/0.872 and 0.951/0.866, respectively.

Conclusion

In this work, we not only achieve superior OD and OC segmentation results, but also confirm that the values calculated through the geometric relationship between the former two are highly related to glaucoma.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Akram MU, Tariq A, Khalid S, Javed MY, Abbas S, Yasin UU (2015) Glaucoma detection using novel optic disc localization, hybrid feature set and classification techniques. Aust Phys Eng Sci Med 38(4):643–655CrossRef Akram MU, Tariq A, Khalid S, Javed MY, Abbas S, Yasin UU (2015) Glaucoma detection using novel optic disc localization, hybrid feature set and classification techniques. Aust Phys Eng Sci Med 38(4):643–655CrossRef
2.
Zurück zum Zitat Baskaran M, Foo RC, Cheng CY, Narayanaswamy AK, Zheng YF, Wu R, Saw SM, Foster PJ, Wong TY, Aung T (2015) The prevalence and types of glaucoma in an urban Chinese population: the Singapore Chinese eye study. JAMA Ophthalmol 133(8):874–880CrossRef Baskaran M, Foo RC, Cheng CY, Narayanaswamy AK, Zheng YF, Wu R, Saw SM, Foster PJ, Wong TY, Aung T (2015) The prevalence and types of glaucoma in an urban Chinese population: the Singapore Chinese eye study. JAMA Ophthalmol 133(8):874–880CrossRef
3.
Zurück zum Zitat Chen LC, Zhu Y, Papandreou G, Schroff F, Adam H (2018) Encoder-decoder with atrous separable convolution for semantic image segmentation. In: Proceedings of the European conference on computer vision (ECCV), pp 801–818 Chen LC, Zhu Y, Papandreou G, Schroff F, Adam H (2018) Encoder-decoder with atrous separable convolution for semantic image segmentation. In: Proceedings of the European conference on computer vision (ECCV), pp 801–818
4.
Zurück zum Zitat Cheng J, Liu J, Xu Y, Yin F, Wong DWK, Tan NM, Tao D, Cheng CY, Aung T, Wong TY (2013) Superpixel classification based optic disc and optic cup segmentation for glaucoma screening. IEEE Trans Med Imaging 32(6):1019–1032CrossRef Cheng J, Liu J, Xu Y, Yin F, Wong DWK, Tan NM, Tao D, Cheng CY, Aung T, Wong TY (2013) Superpixel classification based optic disc and optic cup segmentation for glaucoma screening. IEEE Trans Med Imaging 32(6):1019–1032CrossRef
5.
Zurück zum Zitat Chollet F (2017) Xception: deep learning with depthwise separable convolutions. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 1251–1258 Chollet F (2017) Xception: deep learning with depthwise separable convolutions. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 1251–1258
6.
Zurück zum Zitat Fu H, Cheng J, Xu Y, Wong DWK, Liu J, Cao X (2018) Joint optic disc and cup segmentation based on multi-label deep network and polar transformation. IEEE Trans Med Imaging 37(7):1597–1605CrossRef Fu H, Cheng J, Xu Y, Wong DWK, Liu J, Cao X (2018) Joint optic disc and cup segmentation based on multi-label deep network and polar transformation. IEEE Trans Med Imaging 37(7):1597–1605CrossRef
7.
Zurück zum Zitat Fumero F, Alayón S, Sanchez JL, Sigut J, Gonzalez-Hernandez M (2011) Rim-one: an open retinal image database for optic nerve evaluation. In: 2011 24th international symposium on computer-based medical systems (CBMS). IEEE, pp 1–6 Fumero F, Alayón S, Sanchez JL, Sigut J, Gonzalez-Hernandez M (2011) Rim-one: an open retinal image database for optic nerve evaluation. In: 2011 24th international symposium on computer-based medical systems (CBMS). IEEE, pp 1–6
8.
Zurück zum Zitat Garway-Heath DF, Hitchings RA (1998) Quantitative evaluation of the optic nerve head in early glaucoma. Br J Ophthalmol 82(4):352–361CrossRef Garway-Heath DF, Hitchings RA (1998) Quantitative evaluation of the optic nerve head in early glaucoma. Br J Ophthalmol 82(4):352–361CrossRef
9.
Zurück zum Zitat Goodfellow I, Pouget-Abadie J, Mirza M, Xu B, Warde-Farley D, Ozair S, Courville A, Bengio Y (2014) Generative adversarial nets. In: Advances in neural information processing systems, pp 2672–2680 Goodfellow I, Pouget-Abadie J, Mirza M, Xu B, Warde-Farley D, Ozair S, Courville A, Bengio Y (2014) Generative adversarial nets. In: Advances in neural information processing systems, pp 2672–2680
10.
Zurück zum Zitat Jiang Y, Duan L, Cheng J, Gu Z, Xia H, Fu H, Li C, Liu J (2019) JointRCNN: a region-based convolutional neural network for optic disc and cup segmentation. IEEE Trans Biomed Eng 67(2):335–343CrossRef Jiang Y, Duan L, Cheng J, Gu Z, Xia H, Fu H, Li C, Liu J (2019) JointRCNN: a region-based convolutional neural network for optic disc and cup segmentation. IEEE Trans Biomed Eng 67(2):335–343CrossRef
11.
Zurück zum Zitat Joshi GD, Sivaswamy J, Krishnadas S (2011) Optic disk and cup segmentation from monocular color retinal images for glaucoma assessment. IEEE Trans Med Imaging 30(6):1192–1205CrossRef Joshi GD, Sivaswamy J, Krishnadas S (2011) Optic disk and cup segmentation from monocular color retinal images for glaucoma assessment. IEEE Trans Med Imaging 30(6):1192–1205CrossRef
13.
Zurück zum Zitat Li H, Jialin Pan S, Wang S, Kot AC (2018) Domain generalization with adversarial feature learning. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 5400–5409 Li H, Jialin Pan S, Wang S, Kot AC (2018) Domain generalization with adversarial feature learning. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 5400–5409
14.
Zurück zum Zitat Liu Q, Hong X, Li S, Chen Z, Zhao G, Zou B (2019) A spatial-aware joint optic disc and cup segmentation method. Neurocomputing 359:285–297CrossRef Liu Q, Hong X, Li S, Chen Z, Zhao G, Zou B (2019) A spatial-aware joint optic disc and cup segmentation method. Neurocomputing 359:285–297CrossRef
15.
Zurück zum Zitat Lowell J, Hunter A, Steel D, Basu A, Ryder R, Fletcher E, Kennedy L (2004) Optic nerve head segmentation. IEEE Trans Med Imaging 23(2):256–264CrossRef Lowell J, Hunter A, Steel D, Basu A, Ryder R, Fletcher E, Kennedy L (2004) Optic nerve head segmentation. IEEE Trans Med Imaging 23(2):256–264CrossRef
16.
Zurück zum Zitat Michelson G, Wärntges S, Hornegger J, Lausen B (2008) The papilla as screening parameter for early diagnosis of glaucoma. Dtsch Arztebl Int 105(34–35):583–589PubMedPubMedCentral Michelson G, Wärntges S, Hornegger J, Lausen B (2008) The papilla as screening parameter for early diagnosis of glaucoma. Dtsch Arztebl Int 105(34–35):583–589PubMedPubMedCentral
17.
Zurück zum Zitat Milletari F, Navab N, Ahmadi SA (2016) V-net: fully convolutional neural networks for volumetric medical image segmentation. In: 2016 fourth international conference on 3D vision (3DV), IEEE, pp 565–571 Milletari F, Navab N, Ahmadi SA (2016) V-net: fully convolutional neural networks for volumetric medical image segmentation. In: 2016 fourth international conference on 3D vision (3DV), IEEE, pp 565–571
18.
Zurück zum Zitat Organization WH (2019) World report on vision. In: World report on vision Organization WH (2019) World report on vision. In: World report on vision
19.
Zurück zum Zitat Orlando JI, Fu H, Breda JB, van Keer K, Bathula DR, Diaz-Pinto A, Fang R, Heng PA, Kim J, Lee J, Li X, Liu P, Lu S, Murugesan B, Naranjo V, Phaye SSR, Shankaranarayana SM, Sikka A, Son J, Avd Hengel, Wang S, Wu J, Wu Z, Xu G, Xu Y, Yin P, Li F, Zhang X, Xu Y, Bogunović H (2020) Refuge challenge: a unified framework for evaluating automated methods for glaucoma assessment from fundus photographs. Med Image Anal 59:101570CrossRef Orlando JI, Fu H, Breda JB, van Keer K, Bathula DR, Diaz-Pinto A, Fang R, Heng PA, Kim J, Lee J, Li X, Liu P, Lu S, Murugesan B, Naranjo V, Phaye SSR, Shankaranarayana SM, Sikka A, Son J, Avd Hengel, Wang S, Wu J, Wu Z, Xu G, Xu Y, Yin P, Li F, Zhang X, Xu Y, Bogunović H (2020) Refuge challenge: a unified framework for evaluating automated methods for glaucoma assessment from fundus photographs. Med Image Anal 59:101570CrossRef
20.
Zurück zum Zitat Ramani RG, Shanthamalar JJ (2020) Improved image processing techniques for optic disc segmentation in retinal fundus images. Biomed Signal Process Control 58:101832CrossRef Ramani RG, Shanthamalar JJ (2020) Improved image processing techniques for optic disc segmentation in retinal fundus images. Biomed Signal Process Control 58:101832CrossRef
21.
Zurück zum Zitat Sandler M, Howard A, Zhu M, Zhmoginov A, Chen LC (2018) Mobilenetv2: inverted residuals and linear bottlenecks. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 4510–4520 Sandler M, Howard A, Zhu M, Zhmoginov A, Chen LC (2018) Mobilenetv2: inverted residuals and linear bottlenecks. In: Proceedings of the IEEE conference on computer vision and pattern recognition, pp 4510–4520
22.
Zurück zum Zitat Shankaranarayana SM, Ram K, Mitra K, Sivaprakasam M (2019) Fully convolutional networks for monocular retinal depth estimation and optic disc-cup segmentation. IEEE J Biomed Health Inform 23(4):1417–1426CrossRef Shankaranarayana SM, Ram K, Mitra K, Sivaprakasam M (2019) Fully convolutional networks for monocular retinal depth estimation and optic disc-cup segmentation. IEEE J Biomed Health Inform 23(4):1417–1426CrossRef
23.
Zurück zum Zitat Sivaswamy J, Krishnadas S, Joshi GD, Jain M, Tabish AUS (2014) Drishti-GS: retinal image dataset for optic nerve head (ONH) segmentation. In: 2014 IEEE 11th international symposium on biomedical imaging (ISBI), IEEE, pp 53–56 Sivaswamy J, Krishnadas S, Joshi GD, Jain M, Tabish AUS (2014) Drishti-GS: retinal image dataset for optic nerve head (ONH) segmentation. In: 2014 IEEE 11th international symposium on biomedical imaging (ISBI), IEEE, pp 53–56
24.
Zurück zum Zitat Son J, Park SJ, Jung KH (2019) Towards accurate segmentation of retinal vessels and the optic disc in fundoscopic images with generative adversarial networks. J Digit Imaging 32(3):499–512CrossRef Son J, Park SJ, Jung KH (2019) Towards accurate segmentation of retinal vessels and the optic disc in fundoscopic images with generative adversarial networks. J Digit Imaging 32(3):499–512CrossRef
25.
Zurück zum Zitat Wang S, Yu L, Li K, Yang X, Fu CW, Heng PA (2019) Boundary and entropy-driven adversarial learning for fundus image segmentation. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 102–110 Wang S, Yu L, Li K, Yang X, Fu CW, Heng PA (2019) Boundary and entropy-driven adversarial learning for fundus image segmentation. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 102–110
26.
Zurück zum Zitat Wang S, Yu L, Yang X, Fu CW, Heng PA (2019b) Patch-based output space adversarial learning for joint optic disc and cup segmentation. IEEE Trans Med Imaging 38(11):2485–2495CrossRef Wang S, Yu L, Yang X, Fu CW, Heng PA (2019b) Patch-based output space adversarial learning for joint optic disc and cup segmentation. IEEE Trans Med Imaging 38(11):2485–2495CrossRef
27.
Zurück zum Zitat Yu S, Xiao D, Frost S, Kanagasingam Y (2019) Robust optic disc and cup segmentation with deep learning for glaucoma detection. Comput Med Imaging Graph 74:61–71CrossRef Yu S, Xiao D, Frost S, Kanagasingam Y (2019) Robust optic disc and cup segmentation with deep learning for glaucoma detection. Comput Med Imaging Graph 74:61–71CrossRef
28.
Zurück zum Zitat Zhang Z, Yin FS, Liu J, Wong WK, Tan NM, Lee BH, Cheng J, Wong TY (2010) Origa-light: an online retinal fundus image database for glaucoma analysis and research. In: 2010 annual international conference of the IEEE engineering in medicine and biology. IEEE, pp 3065–3068 Zhang Z, Yin FS, Liu J, Wong WK, Tan NM, Lee BH, Cheng J, Wong TY (2010) Origa-light: an online retinal fundus image database for glaucoma analysis and research. In: 2010 annual international conference of the IEEE engineering in medicine and biology. IEEE, pp 3065–3068
29.
Zurück zum Zitat Zhang Z, Fu H, Dai H, Shen J, Pang Y, Shao L (2019) Et-net: a generic edge-attention guidance network for medical image segmentation. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 442–450 Zhang Z, Fu H, Dai H, Shen J, Pang Y, Shao L (2019) Et-net: a generic edge-attention guidance network for medical image segmentation. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 442–450
30.
Zurück zum Zitat Zheng Y, Stambolian D, O’Brien J, Gee JC (2013) Optic disc and cup segmentation from color fundus photograph using graph cut with priors. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 75–82 Zheng Y, Stambolian D, O’Brien J, Gee JC (2013) Optic disc and cup segmentation from color fundus photograph using graph cut with priors. In: International conference on medical image computing and computer-assisted intervention. Springer, pp 75–82
Metadaten
Titel
Joint optic disc and optic cup segmentation based on boundary prior and adversarial learning
verfasst von
Ling Luo
Dingyu Xue
Feng Pan
Xinglong Feng
Publikationsdatum
08.05.2021
Verlag
Springer International Publishing
Erschienen in
International Journal of Computer Assisted Radiology and Surgery / Ausgabe 6/2021
Print ISSN: 1861-6410
Elektronische ISSN: 1861-6429
DOI
https://doi.org/10.1007/s11548-021-02373-6

Weitere Artikel der Ausgabe 6/2021

International Journal of Computer Assisted Radiology and Surgery 6/2021 Zur Ausgabe

Premium Partner