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2014 | OriginalPaper | Buchkapitel

Lecture 1 Introduction: Computer Science Meets Life Science

verfasst von : Andreas Holzinger

Erschienen in: Biomedical Informatics

Verlag: Springer International Publishing

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Abstract

At the end of this first lecture, you:
  • would be fascinated to see our world in data.
  • would have a basic understanding of the building blocks of life.
  • would be familiar with some differences between Life Sciences and Computer Sciences.
  • would be aware of some possibilities and some limits of Biomedical Informatics.
  • would have some ideas of some future directions of Biomedical Informatics.

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Literatur
Zurück zum Zitat Aebersold R, Mann M (2003) Mass spectrometry-based proteomics. Nature 422(6928):198–207CrossRef Aebersold R, Mann M (2003) Mass spectrometry-based proteomics. Nature 422(6928):198–207CrossRef
Zurück zum Zitat Alagöz F, Calero Valdez A, Wilkowska W, Ziefle M, Dorner S, Holzinger A (2010) From cloud computing to mobile internet, from user focus to culture and hedonism—the crucible of mobile health care and wellness applications. ICPCA10 International Conference on Pervasive Computer Applications 2010, Maribor, Slovenia. IEEE, pp 1–9 Alagöz F, Calero Valdez A, Wilkowska W, Ziefle M, Dorner S, Holzinger A (2010) From cloud computing to mobile internet, from user focus to culture and hedonism—the crucible of mobile health care and wellness applications. ICPCA10 International Conference on Pervasive Computer Applications 2010, Maribor, Slovenia. IEEE, pp 1–9
Zurück zum Zitat Anfinsen CB (1973) Principles that govern the folding of protein chains. Science 181(4096):223–230CrossRef Anfinsen CB (1973) Principles that govern the folding of protein chains. Science 181(4096):223–230CrossRef
Zurück zum Zitat Aral S (2011) Identifying social influence: a comment on opinion leadership and social contagion in new product diffusion. Mark Sci 30(2):217–223CrossRef Aral S (2011) Identifying social influence: a comment on opinion leadership and social contagion in new product diffusion. Mark Sci 30(2):217–223CrossRef
Zurück zum Zitat Auinger A, Ebner M, Nedbal D, Holzinger A (2009) Mixing content and endless collaboration—mashups: towards future personal learning environments. In: Stephanidis C (ed) Universal access in human-computer interaction HCI, part III: applications and services, HCI international 2009, vol 5616, Lecture notes in computer science (LNCS). Springer, Berlin, pp 14–23 Auinger A, Ebner M, Nedbal D, Holzinger A (2009) Mixing content and endless collaboration—mashups: towards future personal learning environments. In: Stephanidis C (ed) Universal access in human-computer interaction HCI, part III: applications and services, HCI international 2009, vol 5616, Lecture notes in computer science (LNCS). Springer, Berlin, pp 14–23
Zurück zum Zitat Barabási AL, Gulbahce N, Loscalzo J (2011) Network medicine: a network-based approach to human disease. Nat Rev Genet 12(1):56–68CrossRef Barabási AL, Gulbahce N, Loscalzo J (2011) Network medicine: a network-based approach to human disease. Nat Rev Genet 12(1):56–68CrossRef
Zurück zum Zitat Barabási AL, Oltvai ZN (2004) Network biology: understanding the cell’s functional organization. Nat Rev Genet 5(2):101–113CrossRef Barabási AL, Oltvai ZN (2004) Network biology: understanding the cell’s functional organization. Nat Rev Genet 5(2):101–113CrossRef
Zurück zum Zitat Bardram JE (2004) Activity-based support for mobility and collaboration in ubiquitous computing. In: Baresi L (ed) Second international conference on ubiquitous mobile information and collaboration systems. Springer, Riga, Latvia, pp 169–184 Bardram JE (2004) Activity-based support for mobility and collaboration in ubiquitous computing. In: Baresi L (ed) Second international conference on ubiquitous mobile information and collaboration systems. Springer, Riga, Latvia, pp 169–184
Zurück zum Zitat Bianchi DW (2012) From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges. Nat Med 18(7):1041–1051CrossRef Bianchi DW (2012) From prenatal genomic diagnosis to fetal personalized medicine: progress and challenges. Nat Med 18(7):1041–1051CrossRef
Zurück zum Zitat Blum BI, Duncan K (1990) A history of medical informatics. Addison Wesley, Reading, MA Blum BI, Duncan K (1990) A history of medical informatics. Addison Wesley, Reading, MA
Zurück zum Zitat Boal D (2012) Mechanics of the cell. Cambridge University Press, CambridgeCrossRef Boal D (2012) Mechanics of the cell. Cambridge University Press, CambridgeCrossRef
Zurück zum Zitat Bobrow DG, Burchfiel JD, Murphy DL, Tomlinson RS (1972) TENEX, a paged time sharing system for the PDP-10. Commun ACM 15(3):135–143CrossRef Bobrow DG, Burchfiel JD, Murphy DL, Tomlinson RS (1972) TENEX, a paged time sharing system for the PDP-10. Commun ACM 15(3):135–143CrossRef
Zurück zum Zitat Boguski MS, Mcintosh MW (2003) Biomedical informatics for proteomics. Nature 422(6928):233–237CrossRef Boguski MS, Mcintosh MW (2003) Biomedical informatics for proteomics. Nature 422(6928):233–237CrossRef
Zurück zum Zitat Boulton G, Rawlins M, Vallance P, Walport M (2011) Science as a public enterprise: the case for open data. Lancet 377(9778):1633–1635CrossRef Boulton G, Rawlins M, Vallance P, Walport M (2011) Science as a public enterprise: the case for open data. Lancet 377(9778):1633–1635CrossRef
Zurück zum Zitat Brooks R (2001) The relationship between matter and life. Nature 409(6818):409–411CrossRef Brooks R (2001) The relationship between matter and life. Nature 409(6818):409–411CrossRef
Zurück zum Zitat Brown T (2012) Introduction to genetics: a molecular approach. Garland, New York Brown T (2012) Introduction to genetics: a molecular approach. Garland, New York
Zurück zum Zitat Burgin M, Eberbach E (2012) Evolutionary computaion and the processes of life: opening statement. ACM Ubiquity 2012:1–13CrossRef Burgin M, Eberbach E (2012) Evolutionary computaion and the processes of life: opening statement. ACM Ubiquity 2012:1–13CrossRef
Zurück zum Zitat Cavin R, Lugli P, Zhirnov V (2012) Science and engineering beyond Moore’s Law. Proc IEEE 100(13):1720–1749CrossRef Cavin R, Lugli P, Zhirnov V (2012) Science and engineering beyond Moore’s Law. Proc IEEE 100(13):1720–1749CrossRef
Zurück zum Zitat Cooper SB, Loewe B, Sorbi A (2008) New computational paradigms: changing conceptions of what is computable. Springer, New YorkCrossRef Cooper SB, Loewe B, Sorbi A (2008) New computational paradigms: changing conceptions of what is computable. Springer, New YorkCrossRef
Zurück zum Zitat Crick F (1970) Central dogma of molecular biology. Nature 227(5258):561–563CrossRef Crick F (1970) Central dogma of molecular biology. Nature 227(5258):561–563CrossRef
Zurück zum Zitat Crick F, Watson J (1953) Molecular structure of nucleic acids. Nature 171(4356):737–738CrossRef Crick F, Watson J (1953) Molecular structure of nucleic acids. Nature 171(4356):737–738CrossRef
Zurück zum Zitat Dill KA, Bromberg S, Yue K, Chan HS, Ftebig KM, Yee DP, Thomas PD (1995) Principles of protein folding—a perspective from simple exact models. Protein Sci 4(4):561–602CrossRef Dill KA, Bromberg S, Yue K, Chan HS, Ftebig KM, Yee DP, Thomas PD (1995) Principles of protein folding—a perspective from simple exact models. Protein Sci 4(4):561–602CrossRef
Zurück zum Zitat Drabovich AP, Pavlou MP, Batruch I, Diamandis EP (2013) Chapter 2—Proteomic and mass spectrometry technologies for biomarker discovery. In: Haleem JI, Timothy DV (eds) Proteomic and metabolomic approaches to biomarker discovery. Academic, Boston, pp 17–37CrossRef Drabovich AP, Pavlou MP, Batruch I, Diamandis EP (2013) Chapter 2—Proteomic and mass spectrometry technologies for biomarker discovery. In: Haleem JI, Timothy DV (eds) Proteomic and metabolomic approaches to biomarker discovery. Academic, Boston, pp 17–37CrossRef
Zurück zum Zitat Fisher C, Lauría E, Chengalur-Smith S (2012) Introduction to information quality. AuthorHouse, Bloomington, IN Fisher C, Lauría E, Chengalur-Smith S (2012) Introduction to information quality. AuthorHouse, Bloomington, IN
Zurück zum Zitat Ge H, Walhout AJM, Vidal M (2003) Integrating ‘omic’information: a bridge between genomics and systems biology. Trends Genet 19(10):551–560CrossRef Ge H, Walhout AJM, Vidal M (2003) Integrating ‘omic’information: a bridge between genomics and systems biology. Trends Genet 19(10):551–560CrossRef
Zurück zum Zitat Gigerenzer G (2008) Gut feelings: short cuts to better decision making. Penguin, London Gigerenzer G (2008) Gut feelings: short cuts to better decision making. Penguin, London
Zurück zum Zitat Gromiha MM (2010) Protein bioinformatics. Elsevier, Amsterdam Gromiha MM (2010) Protein bioinformatics. Elsevier, Amsterdam
Zurück zum Zitat Hawking SW, Penrose R, Atiyah M (1996) The nature of space and time. Princeton University Press, PrincetonMATH Hawking SW, Penrose R, Atiyah M (1996) The nature of space and time. Princeton University Press, PrincetonMATH
Zurück zum Zitat Hersey A, Senger S, Overington JP (2012) Open data for drug discovery: learning from the biological community. Future Med Chem 4(15):1865–1867CrossRef Hersey A, Senger S, Overington JP (2012) Open data for drug discovery: learning from the biological community. Future Med Chem 4(15):1865–1867CrossRef
Zurück zum Zitat Holzinger A (2002) Basiswissen IT/Informatik Band 1: Informationstechnik. Wuerzburg, Vogel BuchverlagMATH Holzinger A (2002) Basiswissen IT/Informatik Band 1: Informationstechnik. Wuerzburg, Vogel BuchverlagMATH
Zurück zum Zitat Holzinger A (2003a) Basiswissen IT/Informatik. Band 2: Informatik. Vogel Buchverlag, Wuerzburg Holzinger A (2003a) Basiswissen IT/Informatik. Band 2: Informatik. Vogel Buchverlag, Wuerzburg
Zurück zum Zitat Holzinger A (2003b) Finger instead of mouse: touch screens as a means of enhancing universal access. In: Carbonell N, Stephanidis C (eds) Universal access: theoretical perspectives, practice and experience, vol 2615, Lecture notes in computer science (LNCS). Springer, Berlin, pp 387–397CrossRef Holzinger A (2003b) Finger instead of mouse: touch screens as a means of enhancing universal access. In: Carbonell N, Stephanidis C (eds) Universal access: theoretical perspectives, practice and experience, vol 2615, Lecture notes in computer science (LNCS). Springer, Berlin, pp 387–397CrossRef
Zurück zum Zitat Holzinger A (2013) Human–computer interaction & knowledge discovery (HCI-KDD): what is the benefit of bringing those two fields to work together? In: Alfredo Cuzzocrea CK, Simos DE, Weippl E, Xu L (eds) Multidisciplinary research and practice for information systems, vol 8127, Lecture notes in computer science (LNCS). Springer, New York, pp 319–328 Holzinger A (2013) Human–computer interaction & knowledge discovery (HCI-KDD): what is the benefit of bringing those two fields to work together? In: Alfredo Cuzzocrea CK, Simos DE, Weippl E, Xu L (eds) Multidisciplinary research and practice for information systems, vol 8127, Lecture notes in computer science (LNCS). Springer, New York, pp 319–328
Zurück zum Zitat Holzinger A, Basic L, Peischl B, Debevc M (2011a) Handwriting recognition on mobile devices: state of the art technology, usability and business analysis. Proceedings of the 8th international conference on electronic business and telecommunications, INSTICC, Sevilla, pp 219–227 Holzinger A, Basic L, Peischl B, Debevc M (2011a) Handwriting recognition on mobile devices: state of the art technology, usability and business analysis. Proceedings of the 8th international conference on electronic business and telecommunications, INSTICC, Sevilla, pp 219–227
Zurück zum Zitat Holzinger A, Dorner S, Födinger M, Valdez A, Ziefle M (2010a) Chances of increasing youth health awareness through mobile wellness applications. In: Leitner G, Hitz M, Holzinger A (eds) HCI in work and learning, life and leisure, vol 6389, Lecture notes in computer science (LNCS). Springer, Berlin, pp 71–81CrossRef Holzinger A, Dorner S, Födinger M, Valdez A, Ziefle M (2010a) Chances of increasing youth health awareness through mobile wellness applications. In: Leitner G, Hitz M, Holzinger A (eds) HCI in work and learning, life and leisure, vol 6389, Lecture notes in computer science (LNCS). Springer, Berlin, pp 71–81CrossRef
Zurück zum Zitat Holzinger A, Emberger W, Wassertheurer S, Neal L (2008a) Design, development and evaluation of online interactive simulation software for learning human genetics. Elektrotech Informationstechnik 125(5):190–196CrossRef Holzinger A, Emberger W, Wassertheurer S, Neal L (2008a) Design, development and evaluation of online interactive simulation software for learning human genetics. Elektrotech Informationstechnik 125(5):190–196CrossRef
Zurück zum Zitat Holzinger A, Kosec P, Schwantzer G, Debevc M, Hofmann-Wellenhof R, Frühauf J (2011b) Design and development of a mobile computer application to reengineer workflows in the hospital and the methodology to evaluate its effectiveness. J Biomed Inform 44(6):968–977CrossRef Holzinger A, Kosec P, Schwantzer G, Debevc M, Hofmann-Wellenhof R, Frühauf J (2011b) Design and development of a mobile computer application to reengineer workflows in the hospital and the methodology to evaluate its effectiveness. J Biomed Inform 44(6):968–977CrossRef
Zurück zum Zitat Holzinger A, Nischelwitzer A, Friedl S, Hu B (2010b) Towards life long learning: three models for ubiquitous applications. Wirel Commun Mob Comput 10(10):1350–1365CrossRef Holzinger A, Nischelwitzer A, Friedl S, Hu B (2010b) Towards life long learning: three models for ubiquitous applications. Wirel Commun Mob Comput 10(10):1350–1365CrossRef
Zurück zum Zitat Holzinger A, Schaupp K, Eder-Halbedl W (2008b) An investigation on acceptance of ubiquitous devices for the elderly in an geriatric hospital environment: using the example of person tracking. In: Miesenberger K, Klaus J, Zagler W, Karshmer A (eds) Computers helping people with special needs, vol 5105, Lecture notes in computer science (LNCS). Springer, Berlin, pp 22–29CrossRef Holzinger A, Schaupp K, Eder-Halbedl W (2008b) An investigation on acceptance of ubiquitous devices for the elderly in an geriatric hospital environment: using the example of person tracking. In: Miesenberger K, Klaus J, Zagler W, Karshmer A (eds) Computers helping people with special needs, vol 5105, Lecture notes in computer science (LNCS). Springer, Berlin, pp 22–29CrossRef
Zurück zum Zitat Holzinger A, Schlögl M, Peischl B, Debevc M (2010c) Preferences of handwriting recognition on mobile information systems in medicine: improving handwriting algorithm on the basis of real-life usability research (Best Paper Award). In: ICE-B 2010—ICETE the international joint conference on e-business and telecommunications, INSTICC, Athens, Greece, pp 120–123 Holzinger A, Schlögl M, Peischl B, Debevc M (2010c) Preferences of handwriting recognition on mobile information systems in medicine: improving handwriting algorithm on the basis of real-life usability research (Best Paper Award). In: ICE-B 2010—ICETE the international joint conference on e-business and telecommunications, INSTICC, Athens, Greece, pp 120–123
Zurück zum Zitat Holzinger A, Schwaberger K, Weitlaner M (2005) Ubiquitous computing for hospital applications: RFID-applications to enable research in real-life environments. In: 29th Annual international conference on computer software & applications (IEEE COMPSAC), IEEE, Edinburgh, UK, pp 19–20 Holzinger A, Schwaberger K, Weitlaner M (2005) Ubiquitous computing for hospital applications: RFID-applications to enable research in real-life environments. In: 29th Annual international conference on computer software & applications (IEEE COMPSAC), IEEE, Edinburgh, UK, pp 19–20
Zurück zum Zitat Holzinger A, Searle G, Peischl B, Debevc M (2012a) An answer to “Who needs a stylus?” on handwriting recognition on mobile devices. e-Business and telecommunications. Communications in computer and information science (CCIS), vol 314. Heidelberg, Springer, pp 156–167 Holzinger A, Searle G, Peischl B, Debevc M (2012a) An answer to “Who needs a stylus?” on handwriting recognition on mobile devices. e-Business and telecommunications. Communications in computer and information science (CCIS), vol 314. Heidelberg, Springer, pp 156–167
Zurück zum Zitat Holzinger A, Simonic K-M (eds) (2011) Information quality in e-Health, vol 7058, Lecture notes in computer science (LNCS). Springer, Heidelberg Holzinger A, Simonic K-M (eds) (2011) Information quality in e-Health, vol 7058, Lecture notes in computer science (LNCS). Springer, Heidelberg
Zurück zum Zitat Holzinger A, Stocker C, Ofner B, Prohaska G, Brabenetz A, Hofmann-Wellenhof R (2013) Combining HCI, natural language processing, and knowledge discovery—potential of IBM content analytics as an assistive technology in the biomedical domain, vol 7947, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 13–24 Holzinger A, Stocker C, Ofner B, Prohaska G, Brabenetz A, Hofmann-Wellenhof R (2013) Combining HCI, natural language processing, and knowledge discovery—potential of IBM content analytics as an assistive technology in the biomedical domain, vol 7947, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 13–24
Zurück zum Zitat Holzinger A, Stocker C, Peischl B, Simonic K-M (2012b) On using entropy for enhancing handwriting preprocessing. Entropy 14(11):2324–2350CrossRef Holzinger A, Stocker C, Peischl B, Simonic K-M (2012b) On using entropy for enhancing handwriting preprocessing. Entropy 14(11):2324–2350CrossRef
Zurück zum Zitat Hunter L (2009) The processes of life: an introduction to molecular biology. MIT Press, Cambridge, MACrossRef Hunter L (2009) The processes of life: an introduction to molecular biology. MIT Press, Cambridge, MACrossRef
Zurück zum Zitat Issaq HJ, Veenstra TD (2013) Chapter 1—Biomarker discovery: study design and execution. In: Haleem JI, Timothy DV (eds) Proteomic and metabolomic approaches to biomarker discovery. Academic, Boston, pp 1–16CrossRef Issaq HJ, Veenstra TD (2013) Chapter 1—Biomarker discovery: study design and execution. In: Haleem JI, Timothy DV (eds) Proteomic and metabolomic approaches to biomarker discovery. Academic, Boston, pp 1–16CrossRef
Zurück zum Zitat Jeanquartier F, Holzinger A (2013) On visual analytics and evaluation in cell physiology: a case study. In: Cuzzocrea A, Kittl C, Simos DE, Weippl E, Xu L (eds) Multidisciplinary research and practice for information systems, vol 8127, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 495–502 Jeanquartier F, Holzinger A (2013) On visual analytics and evaluation in cell physiology: a case study. In: Cuzzocrea A, Kittl C, Simos DE, Weippl E, Xu L (eds) Multidisciplinary research and practice for information systems, vol 8127, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 495–502
Zurück zum Zitat Jeong H, Mason SP, Barabasi AL, Oltvai ZN (2001) Lethality and centrality in protein networks. Nature 411(6833):41–42CrossRef Jeong H, Mason SP, Barabasi AL, Oltvai ZN (2001) Lethality and centrality in protein networks. Nature 411(6833):41–42CrossRef
Zurück zum Zitat Klibanov AM (2001) Improving enzymes by using them in organic solvents. Nature 409(6817):241–246CrossRef Klibanov AM (2001) Improving enzymes by using them in organic solvents. Nature 409(6817):241–246CrossRef
Zurück zum Zitat Komaroff AL (1979) The variability and inaccuracy of medical data. Proc IEEE 67(9):1196–1207CrossRef Komaroff AL (1979) The variability and inaccuracy of medical data. Proc IEEE 67(9):1196–1207CrossRef
Zurück zum Zitat Kuhn K, Knoll A, Mewes H, Schwaiger M, Bode A, Broy M, Daniel H, Feussner H, Gradinger R, Hauner H (2008) From molecules to populations. Methods Inf Med 47(4):283–295 Kuhn K, Knoll A, Mewes H, Schwaiger M, Bode A, Broy M, Daniel H, Feussner H, Gradinger R, Hauner H (2008) From molecules to populations. Methods Inf Med 47(4):283–295
Zurück zum Zitat Lane N, Martin W (2010) The energetics of genome complexity. Nature 467(7318):929–934CrossRef Lane N, Martin W (2010) The energetics of genome complexity. Nature 467(7318):929–934CrossRef
Zurück zum Zitat Mahajan V, Schoeman MEF (1977) The use of computers in hospitals: an analysis of adopters and nonadopters. Interfaces 7:95–107CrossRef Mahajan V, Schoeman MEF (1977) The use of computers in hospitals: an analysis of adopters and nonadopters. Interfaces 7:95–107CrossRef
Zurück zum Zitat Marth JD (2008) A unified vision of the building blocks of life. Nat Cell Biol 10(9):1015–1016CrossRef Marth JD (2008) A unified vision of the building blocks of life. Nat Cell Biol 10(9):1015–1016CrossRef
Zurück zum Zitat Mitchell S, Spiteri MD, Bates J, Coulouris G (2000) Context-aware multimedia computing in the intelligent hospital. ACM Press, Kolding, Denmark, pp 13–18 Mitchell S, Spiteri MD, Bates J, Coulouris G (2000) Context-aware multimedia computing in the intelligent hospital. ACM Press, Kolding, Denmark, pp 13–18
Zurück zum Zitat Mitreva M (2012) Structure, function and diversity of the healthy human microbiome. Nature 486:207–214CrossRef Mitreva M (2012) Structure, function and diversity of the healthy human microbiome. Nature 486:207–214CrossRef
Zurück zum Zitat Mojzsis SJ, Arrhenius G, Mckeegan KD, Harrison TM, Nutman AP, Friend CRL (1996) Evidence for life on Earth before 3,800 million years ago. Nature 384(6604):55–59CrossRef Mojzsis SJ, Arrhenius G, Mckeegan KD, Harrison TM, Nutman AP, Friend CRL (1996) Evidence for life on Earth before 3,800 million years ago. Nature 384(6604):55–59CrossRef
Zurück zum Zitat Molloy JC (2011) The Open Knowledge Foundation: open data means better science. PLoS Biol 9(12):e1001195CrossRef Molloy JC (2011) The Open Knowledge Foundation: open data means better science. PLoS Biol 9(12):e1001195CrossRef
Zurück zum Zitat Moore GE (1965) Cramming more components onto integrated circuits. Electronics 38(8):114–117 Moore GE (1965) Cramming more components onto integrated circuits. Electronics 38(8):114–117
Zurück zum Zitat Neumann JV (1945) First draft of a report on the EDVAC. University of Pennsylvania—techical report, 49 pp Neumann JV (1945) First draft of a report on the EDVAC. University of Pennsylvania—techical report, 49 pp
Zurück zum Zitat Ng PC, Murray SS, Levy S, Venter JC (2009) An agenda for personalized medicine. Nature 461(7265):724–726CrossRef Ng PC, Murray SS, Levy S, Venter JC (2009) An agenda for personalized medicine. Nature 461(7265):724–726CrossRef
Zurück zum Zitat Okumoto S, Jones A, Frommer WB (2012) Quantitative imaging with fluorescent biosensors. Annu Rev Plant Biol 63:663–706CrossRef Okumoto S, Jones A, Frommer WB (2012) Quantitative imaging with fluorescent biosensors. Annu Rev Plant Biol 63:663–706CrossRef
Zurück zum Zitat Patel VL, Kahol K, Buchman T (2011) Biomedical complexity and error. J Biomed Inform 44(3):387–389CrossRef Patel VL, Kahol K, Buchman T (2011) Biomedical complexity and error. J Biomed Inform 44(3):387–389CrossRef
Zurück zum Zitat Petz G, Karpowicz M, Fürschuß H, Auinger A, Stříteský V, Holzinger A (2013) Opinion mining on the Web 2.0—characteristics of user generated content and their impacts, vol 7947, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 35–46 Petz G, Karpowicz M, Fürschuß H, Auinger A, Stříteský V, Holzinger A (2013) Opinion mining on the Web 2.0—characteristics of user generated content and their impacts, vol 7947, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 35–46
Zurück zum Zitat Petz G, Karpowicz M, Fürschuß H, Auinger A, Winkler S, Schaller S, Holzinger A (2012) On text preprocessing for opinion mining outside of laboratory environments. In: Huang R, Ghorbani A, Pasi G, Yamaguchi T, Yen N, Jin B (eds) Active media technology, vol 7669, Lecture notes in computer science (LNCS). Springer, Berlin, pp 618–629CrossRef Petz G, Karpowicz M, Fürschuß H, Auinger A, Winkler S, Schaller S, Holzinger A (2012) On text preprocessing for opinion mining outside of laboratory environments. In: Huang R, Ghorbani A, Pasi G, Yamaguchi T, Yen N, Jin B (eds) Active media technology, vol 7669, Lecture notes in computer science (LNCS). Springer, Berlin, pp 618–629CrossRef
Zurück zum Zitat Pevsner J (2009) Bioinformatics and functional genomics. John Wiley & Sons, Hoboken, NJCrossRef Pevsner J (2009) Bioinformatics and functional genomics. John Wiley & Sons, Hoboken, NJCrossRef
Zurück zum Zitat Rabilloud T, Chevallet M, Luche S, Lelong C (2010) Two-dimensional gel electrophoresis in proteomics: past, present and future. J Proteome 73(11):2064–2077CrossRef Rabilloud T, Chevallet M, Luche S, Lelong C (2010) Two-dimensional gel electrophoresis in proteomics: past, present and future. J Proteome 73(11):2064–2077CrossRef
Zurück zum Zitat Rouwkema J, Rivron NC, Van Blitterswijk CA (2008) Vascularization in tissue engineering. Trends Biotechnol 26(8):434–441CrossRef Rouwkema J, Rivron NC, Van Blitterswijk CA (2008) Vascularization in tissue engineering. Trends Biotechnol 26(8):434–441CrossRef
Zurück zum Zitat Rowen L, Wong GKS, Lane RP, Hood L (2000) Intellectual property—publication rights in the era of open data release policies. Science 289(5486):1881CrossRef Rowen L, Wong GKS, Lane RP, Hood L (2000) Intellectual property—publication rights in the era of open data release policies. Science 289(5486):1881CrossRef
Zurück zum Zitat Sackett DL, Rosenberg WM, Gray J, Haynes RB, Richardson WS (1996) Evidence based medicine: what it is and what it isn’t. Br Med J 312(7023):71CrossRef Sackett DL, Rosenberg WM, Gray J, Haynes RB, Richardson WS (1996) Evidence based medicine: what it is and what it isn’t. Br Med J 312(7023):71CrossRef
Zurück zum Zitat Schidlowski M (1988) A 3,800-million-year isotopic record of life from carbon in sedimentary rocks. Nature 333(6171):313–318CrossRef Schidlowski M (1988) A 3,800-million-year isotopic record of life from carbon in sedimentary rocks. Nature 333(6171):313–318CrossRef
Zurück zum Zitat Schotte F, Lim MH, Jackson TA, Smirnov AV, Soman J, Olson JS, Phillips GN, Wulff M, Anfinrud PA (2003) Watching a protein as it functions with 150-ps time-resolved X-ray crystallography. Science 300(5627):1944–1947CrossRef Schotte F, Lim MH, Jackson TA, Smirnov AV, Soman J, Olson JS, Phillips GN, Wulff M, Anfinrud PA (2003) Watching a protein as it functions with 150-ps time-resolved X-ray crystallography. Science 300(5627):1944–1947CrossRef
Zurück zum Zitat Schrödinger E (1944) What is life? The physical aspect of the living cell. Dublin Institute for Advanced Studies at Trinity College, Dublin Schrödinger E (1944) What is life? The physical aspect of the living cell. Dublin Institute for Advanced Studies at Trinity College, Dublin
Zurück zum Zitat Shadbolt N, O’hara K, Berners-Lee T, Gibbins N, Glaser H, Hall W, Schraefel M (2012) Open government data and the linked data web: Lessons from data. gov. uk. IEEE Intell Syst 27:16–24CrossRef Shadbolt N, O’hara K, Berners-Lee T, Gibbins N, Glaser H, Hall W, Schraefel M (2012) Open government data and the linked data web: Lessons from data. gov. uk. IEEE Intell Syst 27:16–24CrossRef
Zurück zum Zitat Shehu A, Kavraki LE (2012) Modeling structures and motions of loops in protein molecules. Entropy 14(2):252–290CrossRef Shehu A, Kavraki LE (2012) Modeling structures and motions of loops in protein molecules. Entropy 14(2):252–290CrossRef
Zurück zum Zitat Shortliffe EH (2011) Biomedical informatics: defining the science and its role in health professional education. In: Holzinger A, Simonic K-M (eds) Information quality in e-Health, vol 7058, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 711–714CrossRef Shortliffe EH (2011) Biomedical informatics: defining the science and its role in health professional education. In: Holzinger A, Simonic K-M (eds) Information quality in e-Health, vol 7058, Lecture notes in computer science (LNCS). Springer, Heidelberg, pp 711–714CrossRef
Zurück zum Zitat Simonic K-M, Holzinger A (2010) Zur Bedeutung von Information in der Medizin. OCG J 35(1):8 Simonic K-M, Holzinger A (2010) Zur Bedeutung von Information in der Medizin. OCG J 35(1):8
Zurück zum Zitat Sittig DF (1994) Grand challenges in medical informatics. J Am Med Inform Assoc 1(5):412–413CrossRef Sittig DF (1994) Grand challenges in medical informatics. J Am Med Inform Assoc 1(5):412–413CrossRef
Zurück zum Zitat Southern EM (1975) Detection of specific sequences among dna fragments separated by gel-electrophoresis. J Mol Biol 98(3):503–517CrossRef Southern EM (1975) Detection of specific sequences among dna fragments separated by gel-electrophoresis. J Mol Biol 98(3):503–517CrossRef
Zurück zum Zitat Sperelakis N (2012) Cell physiology sourcebook: essentials of membrane biophysics, 4th edn. Elsevier, Amsterdam Sperelakis N (2012) Cell physiology sourcebook: essentials of membrane biophysics, 4th edn. Elsevier, Amsterdam
Zurück zum Zitat Steinbuch K (1957) Informatik: Automatische Informationsverarbeitung. Standard Electric Lorenz (SEL) Nachrichten (4), p 171 Steinbuch K (1957) Informatik: Automatische Informationsverarbeitung. Standard Electric Lorenz (SEL) Nachrichten (4), p 171
Zurück zum Zitat Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122(6):957–968CrossRef Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005) A human protein-protein interaction network: a resource for annotating the proteome. Cell 122(6):957–968CrossRef
Zurück zum Zitat Tanaka H (2010) Omics-based medicine and systems pathology a new perspective for personalized and predictive medicine. Methods Inf Med 49(2):173–185CrossRef Tanaka H (2010) Omics-based medicine and systems pathology a new perspective for personalized and predictive medicine. Methods Inf Med 49(2):173–185CrossRef
Zurück zum Zitat Thompson M, Heneghan C (2012) BMJ OPEN DATA CAMPAIGN. We need to move the debate on open clinical trial data forward. Br Med J 345:e8351CrossRef Thompson M, Heneghan C (2012) BMJ OPEN DATA CAMPAIGN. We need to move the debate on open clinical trial data forward. Br Med J 345:e8351CrossRef
Zurück zum Zitat Trent RJ (2012) Molecular medicine: genomics to personalized healthcare, 4th edn. Elsevier, Amsterdam Trent RJ (2012) Molecular medicine: genomics to personalized healthcare, 4th edn. Elsevier, Amsterdam
Zurück zum Zitat Trygve T (2011) Handbook of epigenetics. Academic, San Diego Trygve T (2011) Handbook of epigenetics. Academic, San Diego
Zurück zum Zitat Varshney U (2009) Pervasive healthcare computing: EMR/EHR, wireless and health monitoring. Springer, New YorkCrossRef Varshney U (2009) Pervasive healthcare computing: EMR/EHR, wireless and health monitoring. Springer, New YorkCrossRef
Zurück zum Zitat Walsh JE (1960) Analyzing medical data: some statistical considerations. IRE Trans Med Electron ME-7(4):362–366CrossRef Walsh JE (1960) Analyzing medical data: some statistical considerations. IRE Trans Med Electron ME-7(4):362–366CrossRef
Zurück zum Zitat Wassertheurer S, Holzinger A, Emberger W, Breitenecker F (2003) Design and development of interactive online-simulations for e-learning. In: Hohmann R (ed) Frontiers in simulation—17th symposium Simulationstechnik in Magdeburg (Germany). SCS European Publication, Delft, pp 97–105 Wassertheurer S, Holzinger A, Emberger W, Breitenecker F (2003) Design and development of interactive online-simulations for e-learning. In: Hohmann R (ed) Frontiers in simulation—17th symposium Simulationstechnik in Magdeburg (Germany). SCS European Publication, Delft, pp 97–105
Zurück zum Zitat Weiser M (1991) The computer for the twenty-first century. Sci Am 265(3):94–104CrossRef Weiser M (1991) The computer for the twenty-first century. Sci Am 265(3):94–104CrossRef
Zurück zum Zitat Westra R, Tuyls K, Saeys Y, Nowé A (2007) Knowledge discovery and emergent complexity in bioinformatics. In: Tuyls K, Westra R, Saeys Y, Nowé A (eds) Knowledge discovery and emergent complexity in bioinformatics. Springer, Berlin, pp 1–9CrossRef Westra R, Tuyls K, Saeys Y, Nowé A (2007) Knowledge discovery and emergent complexity in bioinformatics. In: Tuyls K, Westra R, Saeys Y, Nowé A (eds) Knowledge discovery and emergent complexity in bioinformatics. Springer, Berlin, pp 1–9CrossRef
Zurück zum Zitat Wiltgen M, Holzinger A (2005) Visualization in bioinformatics: protein structures with physicochemical and biological annotations. In: Zara J, Sloup J (eds) Central European multimedia and virtual reality conference (available in EG Eurographics Library). Czech Technical University (CTU), Prague, pp 69–74 Wiltgen M, Holzinger A (2005) Visualization in bioinformatics: protein structures with physicochemical and biological annotations. In: Zara J, Sloup J (eds) Central European multimedia and virtual reality conference (available in EG Eurographics Library). Czech Technical University (CTU), Prague, pp 69–74
Zurück zum Zitat Wiltgen M, Holzinger A, Tilz GP (2007) Interactive analysis and visualization of macromolecular interfaces between proteins. In: Holzinger A (ed) HCI and usability for medicine and health care, vol 4799, Lecture notes in computer science (LNCS). Springer, Berlin, pp 199–212CrossRef Wiltgen M, Holzinger A, Tilz GP (2007) Interactive analysis and visualization of macromolecular interfaces between proteins. In: Holzinger A (ed) HCI and usability for medicine and health care, vol 4799, Lecture notes in computer science (LNCS). Springer, Berlin, pp 199–212CrossRef
Zurück zum Zitat Xiao WZ, Oefner PJ (2001) Denaturing high-performance liquid chromatography: a review. Hum Mutat 17(6):439–474CrossRef Xiao WZ, Oefner PJ (2001) Denaturing high-performance liquid chromatography: a review. Hum Mutat 17(6):439–474CrossRef
Zurück zum Zitat Yapijakis C (2009) Hippocrates of Kos, the father of clinical medicine, and Asclepiades of Bithynia, the father of molecular medicine. In Vivo 23(4):507–514 Yapijakis C (2009) Hippocrates of Kos, the father of clinical medicine, and Asclepiades of Bithynia, the father of molecular medicine. In Vivo 23(4):507–514
Zurück zum Zitat Yildirim P, Ekmekci I, Holzinger A (2013) On knowledge discovery in open medical data on the example of the FDA Drug Adverse Event Reporting System for alendronate (Fosamax). In: Holzinger A, Pasi G (eds) Human-computer interaction and knowledge discovery in complex, unstructured, big data, vol 7947, Lecture notes in computer science (LNCS). Springer, Berlin, pp 195–206CrossRef Yildirim P, Ekmekci I, Holzinger A (2013) On knowledge discovery in open medical data on the example of the FDA Drug Adverse Event Reporting System for alendronate (Fosamax). In: Holzinger A, Pasi G (eds) Human-computer interaction and knowledge discovery in complex, unstructured, big data, vol 7947, Lecture notes in computer science (LNCS). Springer, Berlin, pp 195–206CrossRef
Zurück zum Zitat Yip LY, Yong Chan EC (2013) Chapter 8—Gas chromatography/mass spectrometry-based metabonomics. In: Haleem JI, Timothy DV (eds) Proteomic and metabolomic approaches to biomarker discovery. Academic, Boston, pp 131–144CrossRef Yip LY, Yong Chan EC (2013) Chapter 8—Gas chromatography/mass spectrometry-based metabonomics. In: Haleem JI, Timothy DV (eds) Proteomic and metabolomic approaches to biomarker discovery. Academic, Boston, pp 131–144CrossRef
Zurück zum Zitat Zhang YT, Poon CCY (2010) Editorial note on bio, medical, and health informatics. IEEE Trans Inf Technol Biomed 14(3):543–545CrossRef Zhang YT, Poon CCY (2010) Editorial note on bio, medical, and health informatics. IEEE Trans Inf Technol Biomed 14(3):543–545CrossRef
Zurück zum Zitat Ziefle M, Rocker C, Holzinger A (2011) Medical technology in smart homes: exploring the user’s perspective on privacy, intimacy and trust. 35th Annual IEEE computer software and applications conference workshops (COMPSAC) 2011, IEEE, Munich, pp 410–415 Ziefle M, Rocker C, Holzinger A (2011) Medical technology in smart homes: exploring the user’s perspective on privacy, intimacy and trust. 35th Annual IEEE computer software and applications conference workshops (COMPSAC) 2011, IEEE, Munich, pp 410–415
Metadaten
Titel
Lecture 1 Introduction: Computer Science Meets Life Science
verfasst von
Andreas Holzinger
Copyright-Jahr
2014
DOI
https://doi.org/10.1007/978-3-319-04528-3_1