Sustainability and Life Cycle Assessment in Industrial Biotechnology

Industrial biotechnology (IB) uses biological and biochemical processes in industrial production and is often regarded as an emerging key technology revolutionizing the production of many products while protecting resources and the environment and fostering economic development. This contribution describes the background and sketches the content of the volume ‘Sustainability and Life Cycle Assessment of Industrial Biotechnology’ in the Springer series ‘Advances in Biochemical Engineering/Biotechnology’. The field of IB is introduced from different perspectives (milestones in IB history, economics of biotechnology industry, environmental and social as well as ethical issues and impacts, green chemistry) and in several applications fields (production of chemicals, geobiotechnology in mining).

The past 150 years have seen remarkable discoveries, rapidly growing biological knowledge, and giant technological leaps providing biotechnological solutions for healthcare, food production, and other societal needs. Genetic engineering, miniaturization, and ever-increasing computing power, in particular, have been key technological drivers for the past few decades. Looking ahead, the eventual transition from fossil resources to biomass and CO₂ demands a shift toward a ‘bio-economy’ based on novel production processes and engineered organisms.

Industrial biotechnology is a key tool in the switch from a petro-based to a bio-based economy. For biotechnological processes to compete competitively in cost with chemical synthesis, the best available state-of-the-art technologies are necessary. In the last few years, industrial biotechnology has undergone fast technological development, resulting in a high number of basic technologies emanating from research efforts at universities and research institutions. Academic spin-offs have great importance in technological development because of their innovation from academic backgrounds. Technology transfer through spin-offs can help significantly in translating research at European universities and research institutions into commercial applications. More business oriented and experienced people, similar to founding or business angels, should join such new ventures to achieve successful realization of technology transfer.

A key motivation behind the development and adoption of industrial biotechnology is the reduction of negative environmental impacts. However, accurately assessing these impacts remains a formidable task. Environmental impacts of industrial biotechnology may be significant across a number of categories that include, but may not be limited to, nonrenewable resource depletion, water withdrawals and consumption, climate change, and natural land transformation/occupation. In this chapter, we highlight some key environmental issues across two broad areas: (a) processes that use biobased feedstocks and (b) industrial activity that is supported by biological processes. We also address further issues in accounting for related environmental impacts such as geographic and temporal scope, co-product management, and uncertainty and variability in impacts. Case studies relating to (a) lignocellulosic ethanol, (b) biobased plastics, and (c) enzyme use in the detergent industry are then presented, which illustrate more specific applications. Finally, emerging trends in the area of environmental impacts of biotechnology are discussed.

In this chapter we aim to give an overview of the main societal and ethical issues that are currently voiced around industrial biotechnology. We will illustrate this with some recent cases, such as the development of synthetic artemisinin, synthetic vanillin and vegetable oil produced by engineered algae. We show that current societal and ethical issues in industrial biotechnology centre on the following five themes: sustainability, naturalness, innovation trajectories, risk management and economic justice. In each of these themes, clashing public opinions fuel the public debate on the acceptability of new industrial biotechnology. In some cases this has led to the failure of otherwise promising innovations. In the last part, we provide suggestions on how to deal with these ethical and societal aspects based on the approach of Responsible Research and Innovation (RRI).

The development and implementation of industrial biotechnology (IB) is associated with high expectations for reductions of environmental impacts and risks, particularly in terms of climate change and fossil resource depletion, positive socioeconomic effects, hopes for new competitive products and processes, and development in rural areas. However, not all products and processes are really advantageous with regard to sustainability criteria, and not all are economically successful and accepted by stakeholders. Sustainability and life cycle assessment can play an important role to assess IB products and processes, often accompanying development processes from the early stages onwards. Such assessments can identify key factors regarding sustainability criteria, enable a determination of both product and process performance, or aid in prospectively estimating such performance and its consequences. Thus, development processes, investment decisions, policymaking, and the communication with stakeholders can be supported. This contribution reviews the field of sustainability and life cycle assessment in IB. We explore relevant literature from a methodical and application perspective and categorise suitable methodologies, methods, and tools. We characterise IB from an assessment perspective and indicate challenges, discuss approaches to address these, and identify possible fields of future research. Thus, students, researchers, and practitioners in the field of IB will obtain an up-to-date overview, references to relevant fields of literature, and guidance for own studies in this important and fast-emerging topic.

This chapter focuses on social assessment methods (known as SLCA) applied to industrial biotechnology (IB), which are part of the “life cycle” approach. IB is a heading for a set of different technologies. The first section presents a review of the literature to provide an analysis of the results and limitations of IB SLCA studies, with the main focus on the biofuel industries. Often conducted via a social performance analysis based on CSR (corporate social responsibility) criteria, most studies provide little new information. Nevertheless, there are some studies on the change caused by the emergence of an IB. These studies use national accounts input-output tables, which allow us to predict impacts. The second section suggests rules to follow in order to achieve a “good” SLCA in the field of IB, in other words, to be able to anticipate the main known impacts or at least to carry out the assessment in a rigorous and transparent fashion. The conclusion focuses on the prospects and challenges of IB SLCA, in a world which is experiencing immense upheaval.

One of the many promises of biotechnology is that it allows societies to move away from a fossil-based industry toward a bio-based industry, with positive implications for anthropogenic climate change and resource dependency. The provision of biomass from agriculture or forestry is, however, linked to specific environmental implications that cannot be disregarded in an informed discussion about the role of biotechnology in the twenty-first century. In this chapter, we discuss landuse-related effects of biomass provision such as landscape homogenization, eutrophication, erosion, biodiversity, and others. We also discuss how these effects are represented in Life Cycle Assessment, which is a powerful tool for product sustainability evaluation.

Risk assessment has been used extensively as the main approach to prevent accidents in the chemical and process industry. Industrial biotechnology has many of the same hazards as chemical technology, but also encounters biological hazards related to biological agents. Employees in the biotechnology industry are susceptible to health risks because of different types of exposure to harmful agents. The external environment may also be affected by these agents in cases of accidental release. This chapter first presents several traditional risk assessment methods that may be used in industrial biotechnology after comparing differences between industrial biotechnology and chemical technology. Hazard identification in industrial biotechnology is then discussed, for biological as well as traditional hazards. Furthermore, risk assessment of occupational health and safety related to biological hazards is examined using exposure analysis and risk characterization. A two-stage risk assessment method is recommended to assess environmental and ecological risks in industrial biotechnology. Risk analysis of traditional accidents (fire, explosions, and toxic releases) in industrial biotechnology is also described.

Sustainable chemistry is a broad framework that starts with the function that a chemical product is offering. Not only chemical but also economic and ethical aspects come into focus throughout the complete lifecycle of chemical products. Green chemistry is an important building block for sustainable chemistry and addresses the issue of greener synthesis and, to a certain degree, the more benign properties of chemicals. The principles of green chemistry clearly aim at making chemical reactions and processes more environmentally friendly. Aspects such as atom efficiency, energy efficiency, harmless reactants, renewable resources, and pollution prevention are considered. Despite the progress made toward a “greener” chemistry, biotechnological processes, as processes for the conversion of biomass into value-added products, have not been properly adapted to new developments. Processes used in industrial biotechnology are predominantly linear. This review elaborates on the potential contributions of green chemistry to industrial biotechnology and vice versa. Examples are presented of how green chemistry and biotechnology can be connected to make substrate supply, upstream and downstream processing, and product formation more sustainable. The chapter ends with a case study of adipic acid production from lignin to illustrate the importance of a strong connection between green chemistry and biotechnology.

This chapter highlights the huge and manifold possibilities of reactions which result from the interactions between microorganisms and the geosphere and which are used for mining, mineral processing, and metal recycling. Besides the introduction (Sect. 1) the contribution is divided into five different sections describing the mobilization (Sect. 2) and immobilization (Sect. 3) of valuable substances, the processes of biosorption and bioaccumulation (Sect. 4), as well as transformation of metals into metal organic compounds (Sect. 5). A special topic (Sect. 6) addresses the application of CO₂ as an important component for the formation of energy-rich compounds and chemicals. Each section starts with an overview of the relevant reactions and an explanation of the reaction condition. Afterward information about applications and different technological processes as well as sustainability aspects are provided.

Biotechnology is applied in many industrial areas and uses microorganisms, enzymes, or precursors replacing chemicals to produce goods, including chemicals, plastics, food, agricultural and pharmaceutical products, and energy carriers from renewable raw materials and increasingly also from waste from agriculture and forestry (BIOPRO Baden-Württemberg GmbH, Facts and Figures. Biotechnologie.de. https://​www.​biooekonomie-bw.​de/​en/​articles/​dossiers/​industrial-biotechnology-biological-resources-for-industrial-processes/​, 2013). In comparison with conventional processes, industrial biotechnology processes often run under relatively mild reaction conditions, moderate temperatures, and the use of aqueous media. They might reduce in general the energy requirements and the number of by-products. Since product concentration and formation rate are often very low, the resulting products need to be purified and recovered in marketable quantities in a process that is referred to as downstream processing. Product quantity can also be increased by optimizing the manufacturing processes or biocatalysts used (OECD, the application of biotechnology to industrial sustainability. www.​oecd.​org/​sti/​biotechnology, 2001).

In this context, developing a sustainable bio-based economy that uses eco-efficient processes is one of the key strategic challenges for the twenty-first century. Decisions in the technology development are often supported by sustainability assessment results using different types of sustainability assessment methods. In the last decades, we developed different types of sustainability assessment methods evaluating aspects of economy, ecology, and society to support decision-making processes. We show in this chapter how different types of questions can be answered, how more sustainable solutions can be identified, and how this information can be used for marketing and research activities.