2015 | OriginalPaper | Buchkapitel
Integrating Multimodal Priors in Predictive Models for the Functional Characterization of Alzheimer’s Disease
verfasst von : Mehdi Rahim, Bertrand Thirion, Alexandre Abraham, Michael Eickenberg, Elvis Dohmatob, Claude Comtat, Gael Varoquaux
Erschienen in: Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015
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Functional brain imaging provides key information to characterize neurodegenerative diseases, such as Alzheimer’s disease (AD). Specifically, the metabolic activity measured through fluorodeoxyglucose positron emission tomography (FDG-PET) and the connectivity extracted from resting-state functional magnetic resonance imaging (fMRI), are promising biomarkers that can be used for early assessment and prognosis of the disease and to understand its mechanisms. FDG-PET is the best suited functional marker so far, as it gives a reliable quantitative measure, but is invasive. On the other hand, non-invasive fMRI acquisitions do not provide a straightforward quantification of brain functional activity. To analyze populations solely based on resting-state fMRI, we propose an approach that leverages a metabolic prior learned from FDG-PET. More formally, our classification framework embeds population priors learned from another modality at the voxel-level, which can be seen as a regularization term in the analysis. Experimental results show that our PET-informed approach increases classification accuracy compared to pure fMRI approaches and highlights regions known to be impacted by the disease.