Skip to main content

2017 | OriginalPaper | Buchkapitel

Adversarial Training and Dilated Convolutions for Brain MRI Segmentation

verfasst von : Pim Moeskops, Mitko Veta, Maxime W. Lafarge, Koen A. J. Eppenhof, Josien P. W. Pluim

Erschienen in: Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support

Verlag: Springer International Publishing

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Convolutional neural networks (CNNs) have been applied to various automatic image segmentation tasks in medical image analysis, including brain MRI segmentation. Generative adversarial networks have recently gained popularity because of their power in generating images that are difficult to distinguish from real images.
In this study we use an adversarial training approach to improve CNN-based brain MRI segmentation. To this end, we include an additional loss function that motivates the network to generate segmentations that are difficult to distinguish from manual segmentations. During training, this loss function is optimised together with the conventional average per-voxel cross entropy loss.
The results show improved segmentation performance using this adversarial training procedure for segmentation of two different sets of images and using two different network architectures, both visually and in terms of Dice coefficients.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Dai, W., Doyle, J., Liang, X., Zhang, H., Dong, N., Li, Y., Xing, E.P.: SCAN: structure correcting adversarial network for chest X-rays organ segmentation. arXiv preprint arXiv:1703.08770 (2017) Dai, W., Doyle, J., Liang, X., Zhang, H., Dong, N., Li, Y., Xing, E.P.: SCAN: structure correcting adversarial network for chest X-rays organ segmentation. arXiv preprint arXiv:​1703.​08770 (2017)
2.
Zurück zum Zitat Ganin, Y., Ustinova, E., Ajakan, H., Germain, P., Larochelle, H., Laviolette, F., Marchand, M., Lempitsky, V.: Domain-adversarial training of neural networks. J. Mach. Learn. Res. 17(59), 1–35 (2016)MathSciNetMATH Ganin, Y., Ustinova, E., Ajakan, H., Germain, P., Larochelle, H., Laviolette, F., Marchand, M., Lempitsky, V.: Domain-adversarial training of neural networks. J. Mach. Learn. Res. 17(59), 1–35 (2016)MathSciNetMATH
3.
Zurück zum Zitat Ghafoorian, M., Karssemeijer, N., Heskes, T., Bergkamp, M., Wissink, J., Obels, J., Keizer, K., de Leeuw, F.E., van Ginneken, B., Marchiori, E., Platel, B.: Deep multi-scale location-aware 3D convolutional neural networks for automated detection of lacunes of presumed vascular origin. NeuroImage. Clin. 14, 391–399 (2017) Ghafoorian, M., Karssemeijer, N., Heskes, T., Bergkamp, M., Wissink, J., Obels, J., Keizer, K., de Leeuw, F.E., van Ginneken, B., Marchiori, E., Platel, B.: Deep multi-scale location-aware 3D convolutional neural networks for automated detection of lacunes of presumed vascular origin. NeuroImage. Clin. 14, 391–399 (2017)
4.
Zurück zum Zitat Goodfellow, I., Pouget-Abadie, J., Mirza, M., Xu, B., Warde-Farley, D., Ozair, S., Courville, A., Bengio, Y.: Generative adversarial nets. In: NIPS, pp. 2672–2680 (2014) Goodfellow, I., Pouget-Abadie, J., Mirza, M., Xu, B., Warde-Farley, D., Ozair, S., Courville, A., Bengio, Y.: Generative adversarial nets. In: NIPS, pp. 2672–2680 (2014)
5.
Zurück zum Zitat Havaei, M., Davy, A., Warde-Farley, D., Biard, A., Courville, A., Bengio, Y., Pal, C., Jodoin, P.M., Larochelle, H.: Brain tumor segmentation with deep neural networks. Med. Image Anal. 35, 18–31 (2017)CrossRef Havaei, M., Davy, A., Warde-Farley, D., Biard, A., Courville, A., Bengio, Y., Pal, C., Jodoin, P.M., Larochelle, H.: Brain tumor segmentation with deep neural networks. Med. Image Anal. 35, 18–31 (2017)CrossRef
6.
Zurück zum Zitat Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing internal covariate shift. In: ICML (2015) Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing internal covariate shift. In: ICML (2015)
7.
Zurück zum Zitat Kamnitsas, K., et al.: Unsupervised domain adaptation in brain lesion segmentation with adversarial networks. In: Niethammer, M., Styner, M., Aylward, S., Zhu, H., Oguz, I., Yap, P.-T., Shen, D. (eds.) IPMI 2017. LNCS, vol. 10265, pp. 597–609. Springer, Cham (2017). doi:10.1007/978-3-319-59050-9_47 CrossRef Kamnitsas, K., et al.: Unsupervised domain adaptation in brain lesion segmentation with adversarial networks. In: Niethammer, M., Styner, M., Aylward, S., Zhu, H., Oguz, I., Yap, P.-T., Shen, D. (eds.) IPMI 2017. LNCS, vol. 10265, pp. 597–609. Springer, Cham (2017). doi:10.​1007/​978-3-319-59050-9_​47 CrossRef
8.
Zurück zum Zitat Kamnitsas, K., Ledig, C., Newcombe, V.F., Simpson, J.P., Kane, A.D., Menon, D.K., Rueckert, D., Glocker, B.: Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med. Image Anal. 36, 61–78 (2017)CrossRef Kamnitsas, K., Ledig, C., Newcombe, V.F., Simpson, J.P., Kane, A.D., Menon, D.K., Rueckert, D., Glocker, B.: Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med. Image Anal. 36, 61–78 (2017)CrossRef
9.
Zurück zum Zitat Kohl, S., Bonekamp, D., Schlemmer, H.P., Yaqubi, K., Hohenfellner, M., Hadaschik, B., Radtke, J.P., Maier-Hein, K.: Adversarial networks for the detection of aggressive prostate cancer. arXiv preprint arXiv:1702.08014 (2017) Kohl, S., Bonekamp, D., Schlemmer, H.P., Yaqubi, K., Hohenfellner, M., Hadaschik, B., Radtke, J.P., Maier-Hein, K.: Adversarial networks for the detection of aggressive prostate cancer. arXiv preprint arXiv:​1702.​08014 (2017)
10.
Zurück zum Zitat Landman, B.A., Ribbens, A., Lucas, B., Davatzikos, C., Avants, B., Ledig, C., Ma, D., Rueckert, D., Vandermeulen, D., Maes, F., Erus, G., Wang, J., Holmes, H., Wang, H., Doshi, J., Kornegay, J., Manjon, J., Hammers, A., Akhondi-Asl, A., Asman, A.J., Warfield, S.K.: MICCAI 2012 Workshop on Multi-Atlas Labeling. CreateSpace Independent Publishing Platform, Nice (2012) Landman, B.A., Ribbens, A., Lucas, B., Davatzikos, C., Avants, B., Ledig, C., Ma, D., Rueckert, D., Vandermeulen, D., Maes, F., Erus, G., Wang, J., Holmes, H., Wang, H., Doshi, J., Kornegay, J., Manjon, J., Hammers, A., Akhondi-Asl, A., Asman, A.J., Warfield, S.K.: MICCAI 2012 Workshop on Multi-Atlas Labeling. CreateSpace Independent Publishing Platform, Nice (2012)
11.
Zurück zum Zitat Luc, P., Couprie, C., Chintala, S., Verbeek, J.: Semantic segmentation using adversarial networks. In: NIPS Workshop on Adversarial Training (2016) Luc, P., Couprie, C., Chintala, S., Verbeek, J.: Semantic segmentation using adversarial networks. In: NIPS Workshop on Adversarial Training (2016)
12.
Zurück zum Zitat Mendrik, A.M., Vincken, K.L., Kuijf, H.J., Breeuwer, M., Bouvy, W.H., de Bresser, J., Alansary, A., de Bruijne, M., Carass, A., El-Baz, A., Jog, A., Katyal, R., Khan, A.R., van der Lijn, F., Mahmood, Q., Mukherjee, R., van Opbroek, A., Paneri, S., Pereira, S., et al.: MRBrainS challenge: online evaluation framework for brain image segmentation in 3T MRI scans. Comput. Intel. Neurosci. 2015 (2015). Article No. 813696 Mendrik, A.M., Vincken, K.L., Kuijf, H.J., Breeuwer, M., Bouvy, W.H., de Bresser, J., Alansary, A., de Bruijne, M., Carass, A., El-Baz, A., Jog, A., Katyal, R., Khan, A.R., van der Lijn, F., Mahmood, Q., Mukherjee, R., van Opbroek, A., Paneri, S., Pereira, S., et al.: MRBrainS challenge: online evaluation framework for brain image segmentation in 3T MRI scans. Comput. Intel. Neurosci. 2015 (2015). Article No. 813696
13.
Zurück zum Zitat Moeskops, P., Viergever, M.A., Mendrik, A.M., de Vries, L.S., Benders, M.J., Išgum, I.: Automatic segmentation of MR brain images with a convolutional neural network. IEEE Trans. Med. Imag. 35(5), 1252–1261 (2016)CrossRef Moeskops, P., Viergever, M.A., Mendrik, A.M., de Vries, L.S., Benders, M.J., Išgum, I.: Automatic segmentation of MR brain images with a convolutional neural network. IEEE Trans. Med. Imag. 35(5), 1252–1261 (2016)CrossRef
14.
Zurück zum Zitat Moeskops, P., Wolterink, J.M., Velden, B.H.M., Gilhuijs, K.G.A., Leiner, T., Viergever, M.A., Išgum, I.: Deep learning for multi-task medical image segmentation in multiple modalities. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 478–486. Springer, Cham (2016). doi:10.1007/978-3-319-46723-8_55 CrossRef Moeskops, P., Wolterink, J.M., Velden, B.H.M., Gilhuijs, K.G.A., Leiner, T., Viergever, M.A., Išgum, I.: Deep learning for multi-task medical image segmentation in multiple modalities. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 478–486. Springer, Cham (2016). doi:10.​1007/​978-3-319-46723-8_​55 CrossRef
15.
Zurück zum Zitat Radford, A., Metz, L., Chintala, S.: Unsupervised representation learning with deep convolutional generative adversarial networks. In: ICLR (2016) Radford, A., Metz, L., Chintala, S.: Unsupervised representation learning with deep convolutional generative adversarial networks. In: ICLR (2016)
16.
Zurück zum Zitat Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)MathSciNetMATH Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)MathSciNetMATH
18.
Zurück zum Zitat Wolterink, J.M., Leiner, T., Viergever, M.A., Išgum, I.: Dilated convolutional neural networks for cardiovascular MR segmentation in congenital heart disease. In: Zuluaga, M.A., Bhatia, K., Kainz, B., Moghari, M.H., Pace, D.F. (eds.) RAMBO/HVSMR -2016. LNCS, vol. 10129, pp. 95–102. Springer, Cham (2017). doi:10.1007/978-3-319-52280-7_9 CrossRef Wolterink, J.M., Leiner, T., Viergever, M.A., Išgum, I.: Dilated convolutional neural networks for cardiovascular MR segmentation in congenital heart disease. In: Zuluaga, M.A., Bhatia, K., Kainz, B., Moghari, M.H., Pace, D.F. (eds.) RAMBO/HVSMR -2016. LNCS, vol. 10129, pp. 95–102. Springer, Cham (2017). doi:10.​1007/​978-3-319-52280-7_​9 CrossRef
19.
Zurück zum Zitat Yu, F., Koltun, V.: Multi-scale context aggregation by dilated convolutions. In: ICLR (2016) Yu, F., Koltun, V.: Multi-scale context aggregation by dilated convolutions. In: ICLR (2016)
20.
Zurück zum Zitat Zhang, W., Li, R., Deng, H., Wang, L., Lin, W., Ji, S., Shen, D.: Deep convolutional neural networks for multi-modality isointense infant brain image segmentation. NeuroImage 108, 214–224 (2015)CrossRef Zhang, W., Li, R., Deng, H., Wang, L., Lin, W., Ji, S., Shen, D.: Deep convolutional neural networks for multi-modality isointense infant brain image segmentation. NeuroImage 108, 214–224 (2015)CrossRef
Metadaten
Titel
Adversarial Training and Dilated Convolutions for Brain MRI Segmentation
verfasst von
Pim Moeskops
Mitko Veta
Maxime W. Lafarge
Koen A. J. Eppenhof
Josien P. W. Pluim
Copyright-Jahr
2017
DOI
https://doi.org/10.1007/978-3-319-67558-9_7

Premium Partner