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2018 | OriginalPaper | Buchkapitel

DSMS-FCN: A Deeply Supervised Multi-scale Fully Convolutional Network for Automatic Segmentation of Intervertebral Disc in 3D MR Images

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Abstract

This paper addresses the challenging problem of segmentation of intervertebral discs (IVDs) in three-dimensional (3D) T2-weighted magnetic resonance (MR) images. We propose a deeply supervised multi-scale fully convolutional network for segmentation of IVDs in 3D MR images. After training, our network can directly map a whole volumetric data to its volume-wise labels. Multi-scale deep supervision is designed to alleviate the potential gradient vanishing problem during training. It is also used together with partial transfer learning to boost the training efficiency when only small set of labeled training data are available. The present method was validated on the MICCAI 2015 IVD segmentation challenge datasets. Our method achieved a mean Dice overlap coefficient of 92.0% and a mean average symmetric surface distance of 0.41 mm. The results achieved by our method are better than those achieved by the state-of-the-art methods.

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Literatur
1.
Zurück zum Zitat Modic, M., Ross, J.: Lumbar degenerative disk disease. Radiology 245(1), 43–61 (2007)CrossRef Modic, M., Ross, J.: Lumbar degenerative disk disease. Radiology 245(1), 43–61 (2007)CrossRef
3.
Zurück zum Zitat An, H., Anderson, P., Haughton, V., Iatridis, J., Kang, J., Lotz, J., Natarajan, R., Oegema, T.J., Roughley, P., Setton, L., Urban, J., Videman, T., Andersson, G., Weinstein, J.: Introduction: disc degeneration: summary. Spine 29(23), 2677–2678 (2004)CrossRef An, H., Anderson, P., Haughton, V., Iatridis, J., Kang, J., Lotz, J., Natarajan, R., Oegema, T.J., Roughley, P., Setton, L., Urban, J., Videman, T., Andersson, G., Weinstein, J.: Introduction: disc degeneration: summary. Spine 29(23), 2677–2678 (2004)CrossRef
4.
Zurück zum Zitat Chevrefils, C., Cheriet, F., Aubin, C., Grimard, G.: Texture analysis for automatic segmentation of intervertebral disks of scoliotic spines from MR images. IEEE Trans. Inf Technol. Biomed. 13(4), 608–620 (2009)CrossRef Chevrefils, C., Cheriet, F., Aubin, C., Grimard, G.: Texture analysis for automatic segmentation of intervertebral disks of scoliotic spines from MR images. IEEE Trans. Inf Technol. Biomed. 13(4), 608–620 (2009)CrossRef
5.
Zurück zum Zitat Michopoulou, S., Costaridou, L., Panagiotopoulos, E., Speller, R., Panayiotakis, G., Todd-Pokropek, A.: Atlas-based segmentation of degenerated lumbar intervertebral discs from MR images of the spine. IEEE Trans. Biomed. Eng. 56(9), 2225–2231 (2009)CrossRef Michopoulou, S., Costaridou, L., Panagiotopoulos, E., Speller, R., Panayiotakis, G., Todd-Pokropek, A.: Atlas-based segmentation of degenerated lumbar intervertebral discs from MR images of the spine. IEEE Trans. Biomed. Eng. 56(9), 2225–2231 (2009)CrossRef
6.
7.
Zurück zum Zitat Neubert, A., Fripp, J., Engstrom, C., Schwarz, R., Lauer, L., Salvado, O., Crozier, S.: Automated detection, 3D segmentation and analysis of high resolution spine MR images using statistical shape models. Phys. Med. Biol. 57(24), 8457–8376 (2012)CrossRef Neubert, A., Fripp, J., Engstrom, C., Schwarz, R., Lauer, L., Salvado, O., Crozier, S.: Automated detection, 3D segmentation and analysis of high resolution spine MR images using statistical shape models. Phys. Med. Biol. 57(24), 8457–8376 (2012)CrossRef
8.
Zurück zum Zitat Law, M., Tay, K., Leung, A., Garvin, G., Li, S.: Intervertebral disc segmentation in MR images using anisotropic oriented flux. Med. Image Anal. 17(1), 43–61 (2013)CrossRef Law, M., Tay, K., Leung, A., Garvin, G., Li, S.: Intervertebral disc segmentation in MR images using anisotropic oriented flux. Med. Image Anal. 17(1), 43–61 (2013)CrossRef
9.
Zurück zum Zitat Zheng, G., Chu, C., Belavý, D., Ibragimov, B., Korez, R., Vrtovec, T., Hutt, H., Everson, R., Meakin, J., Andrade, I., Glocker, B., Chen, H., Dou, Q., Heng, P., Wang, C., Forsberg, D., Neubert, A., Fripp, J., Urschler, M., Stern, D., Wimmer, M., Novikov, A., Cheng, H., Armbrecht, G., Felsenberg, D., Li, S.: Evaluation and comparison of 3D intervertebral disc localization and segmentation methods for 3D T2 MR data: a grand challenge. Med. Image Anal. 35, 327–344 (2017)CrossRef Zheng, G., Chu, C., Belavý, D., Ibragimov, B., Korez, R., Vrtovec, T., Hutt, H., Everson, R., Meakin, J., Andrade, I., Glocker, B., Chen, H., Dou, Q., Heng, P., Wang, C., Forsberg, D., Neubert, A., Fripp, J., Urschler, M., Stern, D., Wimmer, M., Novikov, A., Cheng, H., Armbrecht, G., Felsenberg, D., Li, S.: Evaluation and comparison of 3D intervertebral disc localization and segmentation methods for 3D T2 MR data: a grand challenge. Med. Image Anal. 35, 327–344 (2017)CrossRef
11.
Zurück zum Zitat Kelm, M., Wels, M., Zhou, S., Seifert, S., Suehling, M., Zheng, Y., Comaniciu, D.: Spine detection in CT and MR using iterated marginal space learning. Med. Image Anal. 17(8), 1283–1292 (2013)CrossRef Kelm, M., Wels, M., Zhou, S., Seifert, S., Suehling, M., Zheng, Y., Comaniciu, D.: Spine detection in CT and MR using iterated marginal space learning. Med. Image Anal. 17(8), 1283–1292 (2013)CrossRef
12.
Zurück zum Zitat Chen, C., Belavy, D., Yu, W., Chu, C., Armbrecht, G., Bansmann, M., Felsenberg, D., Zheng, G.: Localization and segmentation of 3D intervertebral discs in MR images by data driven estimation. IEEE Trans. Med. Imaging 34(8), 1719–1729 (2015)CrossRef Chen, C., Belavy, D., Yu, W., Chu, C., Armbrecht, G., Bansmann, M., Felsenberg, D., Zheng, G.: Localization and segmentation of 3D intervertebral discs in MR images by data driven estimation. IEEE Trans. Med. Imaging 34(8), 1719–1729 (2015)CrossRef
13.
Zurück zum Zitat Wang, Z., Zhen, X., Tay, K., Osman, S., Romano, W., Li, S.: Regression segmentation for M\(^3\) spinal images. IEEE Trans. Med. Imaging 34(8), 1640–1648 (2015)CrossRef Wang, Z., Zhen, X., Tay, K., Osman, S., Romano, W., Li, S.: Regression segmentation for M\(^3\) spinal images. IEEE Trans. Med. Imaging 34(8), 1640–1648 (2015)CrossRef
14.
Zurück zum Zitat Bengio, Y.: Learning deep architectures for AI. Found. Trends Mach. Learn. 2(1), 1–127 (2009)CrossRef Bengio, Y.: Learning deep architectures for AI. Found. Trends Mach. Learn. 2(1), 1–127 (2009)CrossRef
15.
Zurück zum Zitat Krizhevsky, A., Sutskever, I., Hinton, G.: ImageNet classification with deep convolutional neural networks. In: Pereira, F., et al. (eds.) Proceedings of Neural Information Processing Systems – NIPS 2012, vol. 25, pp. 1097–1105. NIPS (2012) Krizhevsky, A., Sutskever, I., Hinton, G.: ImageNet classification with deep convolutional neural networks. In: Pereira, F., et al. (eds.) Proceedings of Neural Information Processing Systems – NIPS 2012, vol. 25, pp. 1097–1105. NIPS (2012)
16.
Zurück zum Zitat Prasoon, A., Petersen, K., Igel, C., Lauze, F., Dam, E., Nielsen, M.: Deep feature learning for knee cartilage segmentation using a triplanar convolutional neural network. In: Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N. (eds.) MICCAI 2013. LNCS, vol. 8150, pp. 246–253. Springer, Heidelberg (2013). https://doi.org/10.1007/978-3-642-40763-5_31CrossRef Prasoon, A., Petersen, K., Igel, C., Lauze, F., Dam, E., Nielsen, M.: Deep feature learning for knee cartilage segmentation using a triplanar convolutional neural network. In: Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N. (eds.) MICCAI 2013. LNCS, vol. 8150, pp. 246–253. Springer, Heidelberg (2013). https://​doi.​org/​10.​1007/​978-3-642-40763-5_​31CrossRef
17.
18.
Zurück zum Zitat Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of IEEE Conference on Computer Vision and Pattern Recognition - CVPR 2015, pp. 3431–3440 (2015) Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of IEEE Conference on Computer Vision and Pattern Recognition - CVPR 2015, pp. 3431–3440 (2015)
19.
Zurück zum Zitat Roth, H., Yao, J., Lu, L., Stieger, J., Burns, J., Summers, R.: Detection of sclerotic spine metastases via random aggregation of deep convolutional neural network classifications. In: Yao, J., et al. (eds.) Proceedings of 2nd MICCAI Workshop on Computational Methods and Clinical Applications for Spine CSI 2014, LNCVB, vol. 20, pp. 3–12. Springer (2015). https://doi.org/10.1007/978-3-319-14148-0_1CrossRef Roth, H., Yao, J., Lu, L., Stieger, J., Burns, J., Summers, R.: Detection of sclerotic spine metastases via random aggregation of deep convolutional neural network classifications. In: Yao, J., et al. (eds.) Proceedings of 2nd MICCAI Workshop on Computational Methods and Clinical Applications for Spine CSI 2014, LNCVB, vol. 20, pp. 3–12. Springer (2015). https://​doi.​org/​10.​1007/​978-3-319-14148-0_​1CrossRef
20.
Zurück zum Zitat Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-Net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49CrossRef Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-Net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://​doi.​org/​10.​1007/​978-3-319-46723-8_​49CrossRef
21.
Zurück zum Zitat Milletari, F., Navab, N., Ahmadi, S.A.: V-Net: fully convolutional neural networks for volumetric medical image segmentation. In: Proceedings of 4th International Conference on 3D Vision - 3DV 2016, pp. 565–571. IEEE (2016) Milletari, F., Navab, N., Ahmadi, S.A.: V-Net: fully convolutional neural networks for volumetric medical image segmentation. In: Proceedings of 4th International Conference on 3D Vision - 3DV 2016, pp. 565–571. IEEE (2016)
22.
Zurück zum Zitat Dou, Q., Yu, L., Chen, H., Jin, Y., Yang, X., Qin, J., Heng, P.A.: 3D deeply supervised network for automated segmentation of volumetric medical images. Med. Image Anal. 41, 40–54 (2017)CrossRef Dou, Q., Yu, L., Chen, H., Jin, Y., Yang, X., Qin, J., Heng, P.A.: 3D deeply supervised network for automated segmentation of volumetric medical images. Med. Image Anal. 41, 40–54 (2017)CrossRef
23.
Zurück zum Zitat Chen, H., Dou, Q., Wang, X., Qin, J., Cheng, J.C.Y., Heng, P.-A.: 3D fully convolutional networks for intervertebral disc localization and segmentation. In: Zheng, G., Liao, H., Jannin, P., Cattin, P., Lee, S.-L. (eds.) MIAR 2016. LNCS, vol. 9805, pp. 375–382. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-43775-0_34CrossRef Chen, H., Dou, Q., Wang, X., Qin, J., Cheng, J.C.Y., Heng, P.-A.: 3D fully convolutional networks for intervertebral disc localization and segmentation. In: Zheng, G., Liao, H., Jannin, P., Cattin, P., Lee, S.-L. (eds.) MIAR 2016. LNCS, vol. 9805, pp. 375–382. Springer, Cham (2016). https://​doi.​org/​10.​1007/​978-3-319-43775-0_​34CrossRef
25.
Zurück zum Zitat He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of IEEE Conference on Computer Vision and Pattern Recognition - CVPR 2016, pp. 770–778. IEEE (2016) He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of IEEE Conference on Computer Vision and Pattern Recognition - CVPR 2016, pp. 770–778. IEEE (2016)
26.
27.
Zurück zum Zitat Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing. In: Proceedings of 32nd International Conference on Machine Learning - ICML 2015, vol. 37, pp. 448–456. PLMR (2015) Ioffe, S., Szegedy, C.: Batch normalization: accelerating deep network training by reducing. In: Proceedings of 32nd International Conference on Machine Learning - ICML 2015, vol. 37, pp. 448–456. PLMR (2015)
28.
Zurück zum Zitat Yosinski, J., Clune, J., Bengio, Y., Lipson, H.: How transferable are features in deep neural networks? In: Ghahramani, Z., et al. (eds.) Proceedings of Advances in Neural Information Processing Systems - NIPS 2014, pp. 3320–3328. MIT Press (2014) Yosinski, J., Clune, J., Bengio, Y., Lipson, H.: How transferable are features in deep neural networks? In: Ghahramani, Z., et al. (eds.) Proceedings of Advances in Neural Information Processing Systems - NIPS 2014, pp. 3320–3328. MIT Press (2014)
29.
Zurück zum Zitat Zeng, G., Yang, X., Li, J., Yu, L., Heng, P., Zheng, G.: 3D U-Net with multi-level deep supervision:fully automatic segmentation of proximal femur in 3D MR images. In: 8th MICCAI International Workshop on Machine Learning in Medical Imaging - MLMI 2017 (2017) Zeng, G., Yang, X., Li, J., Yu, L., Heng, P., Zheng, G.: 3D U-Net with multi-level deep supervision:fully automatic segmentation of proximal femur in 3D MR images. In: 8th MICCAI International Workshop on Machine Learning in Medical Imaging - MLMI 2017 (2017)
30.
Zurück zum Zitat Fang, Q., Boas, D.: Tetrahedral mesh generation from volumetric binary and gray-scale images. In: Proceedings of 6th IEEE International Symposium on Biomedical Imaging - ISBI 2009, pp. 1142–1145. IEEE (2009) Fang, Q., Boas, D.: Tetrahedral mesh generation from volumetric binary and gray-scale images. In: Proceedings of 6th IEEE International Symposium on Biomedical Imaging - ISBI 2009, pp. 1142–1145. IEEE (2009)
31.
Zurück zum Zitat Heimann, T., van Ginneken, B., Styner, M., Arzhaeva, Y., Aurich, V., Bauer, C., Beck, A., Becker, C., Beichel, R., Bekes, G., Bello, F., Binnig, G., Bischof, H., Bornik, A., Cashman, P., Chi, Y., Cordova, A., Dawant, B., Fidrich, M., Furst, J., Furukawa, D., Grenacher, L., Hornegger, J., Kainmüller, D., Kitney, R., Kobatake, H., Lamecker, H., Lange, T., Lee, J., Lennon, B., Li, R., Li, S., Meinzer, H., Nemeth, G., Raicu, D., Rau, A., van Rikxoort, E., Rousson, M., Rusko, L., Saddi, K., Schmidt, G., Seghers, D., Shimizu, A., Slagmolen, P., Sorantin, E., Soza, G., Susomboon, R., Waite, J., Wimmer, A., Wolf, I.: Comparison and evaluation of methods for liver segmentation from CT datasets. IEEE Trans. Med. Imaging 28(8), 1251–1265 (2009)CrossRef Heimann, T., van Ginneken, B., Styner, M., Arzhaeva, Y., Aurich, V., Bauer, C., Beck, A., Becker, C., Beichel, R., Bekes, G., Bello, F., Binnig, G., Bischof, H., Bornik, A., Cashman, P., Chi, Y., Cordova, A., Dawant, B., Fidrich, M., Furst, J., Furukawa, D., Grenacher, L., Hornegger, J., Kainmüller, D., Kitney, R., Kobatake, H., Lamecker, H., Lange, T., Lee, J., Lennon, B., Li, R., Li, S., Meinzer, H., Nemeth, G., Raicu, D., Rau, A., van Rikxoort, E., Rousson, M., Rusko, L., Saddi, K., Schmidt, G., Seghers, D., Shimizu, A., Slagmolen, P., Sorantin, E., Soza, G., Susomboon, R., Waite, J., Wimmer, A., Wolf, I.: Comparison and evaluation of methods for liver segmentation from CT datasets. IEEE Trans. Med. Imaging 28(8), 1251–1265 (2009)CrossRef
32.
Zurück zum Zitat Arya, S., Mount, D., Netanyahu, N., Silverman, R., Wu, A.: An optimal algorithm for approximate nearest neighbor searching. J. ACM 45(6), 891–923 (1998) Arya, S., Mount, D., Netanyahu, N., Silverman, R., Wu, A.: An optimal algorithm for approximate nearest neighbor searching. J. ACM 45(6), 891–923 (1998)
33.
Zurück zum Zitat Karasawa, K., Oda, M., Kitasaka, T., Misawa, K., Fujiwara, M., Chu, C., Zheng, G., Rueckert, D., Mori, K.: Multi-atlas pancreas segmentation: atlas selection based on vessel structure. Med. Image Anal. 39, 18–28 (2017)CrossRef Karasawa, K., Oda, M., Kitasaka, T., Misawa, K., Fujiwara, M., Chu, C., Zheng, G., Rueckert, D., Mori, K.: Multi-atlas pancreas segmentation: atlas selection based on vessel structure. Med. Image Anal. 39, 18–28 (2017)CrossRef
34.
Zurück zum Zitat Korez, R., Ibragimov, B., Likar, B., Pernuš, F., Vrtovec, T.: Deformable model-based segmentation of intervertebral discs from MR spine images by using the SSC descriptor. In: Vrtovec, T., Yao, J., Glocker, B., Klinder, T., Frangi, A., Zheng, G., Li, S. (eds.) CSI 2015. LNCS, vol. 9402, pp. 117–124. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-41827-8_11CrossRef Korez, R., Ibragimov, B., Likar, B., Pernuš, F., Vrtovec, T.: Deformable model-based segmentation of intervertebral discs from MR spine images by using the SSC descriptor. In: Vrtovec, T., Yao, J., Glocker, B., Klinder, T., Frangi, A., Zheng, G., Li, S. (eds.) CSI 2015. LNCS, vol. 9402, pp. 117–124. Springer, Cham (2016). https://​doi.​org/​10.​1007/​978-3-319-41827-8_​11CrossRef
Metadaten
Titel
DSMS-FCN: A Deeply Supervised Multi-scale Fully Convolutional Network for Automatic Segmentation of Intervertebral Disc in 3D MR Images
verfasst von
Guodong Zeng
Guoyan Zheng
Copyright-Jahr
2018
DOI
https://doi.org/10.1007/978-3-319-74113-0_13

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