Anzeige
Erschienen in:
2009 | OriginalPaper | Buchkapitel
BiHEA: A Hybrid Evolutionary Approach for Microarray Biclustering
verfasst von : Cristian Andrés Gallo, Jessica Andrea Carballido, Ignacio Ponzoni
Erschienen in: Advances in Bioinformatics and Computational Biology
Verlag: Springer Berlin Heidelberg
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
In this paper a new hybrid approach that integrates an evolutionary algorithm with local search for microarray biclustering is presented. The novelty of this proposal is constituted by the incorporation of two mechanisms: the first one avoids loss of good solutions through generations and overcomes the high degree of overlap in the final population; and the other one preserves an adequate level of genotypic diversity. The performance of the memetic strategy was compared with the results of several salient biclustering algorithms over synthetic data with different overlap degrees and noise levels. In this regard, our proposal achieves results that outperform the ones obtained by the referential methods. Finally, a study on real data was performed in order to demonstrate the biological relevance of the results of our approach.