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Journal of Materials Science
Erschienen in: Journal of Materials Science 4/2015

01.02.2015 | Original Paper

Arsenic sulfide nanoparticles prepared by milling: properties, free-volume characterization, and anti-cancer effects

verfasst von: Zdenka Bujňáková, Peter Baláž, Petre Makreski, Gligor Jovanovski, Mária Čaplovičová, Ľubomír Čaplovič, Oleh Shpotyuk, Adam Ingram, Te-Chang Lee, Jing-Jy Cheng, Ján Sedlák, Erika Turianicová, Anna Zorkovská

Erschienen in: Journal of Materials Science | Ausgabe 4/2015

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Abstract

In this paper, nanosuspensions of three arsenic sulfide (As4S4) compounds, commercial synthetic arsenic(II) sulfide, and natural realgar and pararealgar minerals were prepared. Nanosuspensions were obtained by ultrafine wet milling in a circulation mill. The zeta potential and particle size distribution were measured for stability estimation. Structural changes were studied using Raman and Fourier transform infrared spectroscopic methods and positron annihilation lifetime method. The morphology of the prepared nanoparticles was determined using scanning and transmission electron microscopy. The anticancer effects were tested using flow cytometry and western blotting analysis. The average particle size in the individual samples varied from 137 to 153 nm. The effects of milling were associated with the formation of arsenic sulfide crystalline nanoparticles and the fragmentation of the corresponding free-volume entities. Consequently, an increase in the arsenic dissolution was observed. The anti-cancer effects of the nanosuspensions were verified on the human cancer H460 cell line, in which case DNA damage and greater numbers of apoptotic cells were observed.
Vorheriger Artikel Micellization behavior of the mixtures of amino sulfonate amphoteric surfactant and octadecyltrimethyl ammonium bromide in aqueous solution at 40 °C: a tensiometric study
Nächster Artikel Effect of Y2O3 and CeO2 on the crystallisation behaviour and mechanical properties of glass–ceramics in the system MgO/Al2O3/SiO2/ZrO2

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Metadaten
Titel
Arsenic sulfide nanoparticles prepared by milling: properties, free-volume characterization, and anti-cancer effects
verfasst von
Zdenka Bujňáková
Peter Baláž
Petre Makreski
Gligor Jovanovski
Mária Čaplovičová
Ľubomír Čaplovič
Oleh Shpotyuk
Adam Ingram
Te-Chang Lee
Jing-Jy Cheng
Ján Sedlák
Erika Turianicová
Anna Zorkovská
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 4/2015
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-014-8763-5

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