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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 6/2014

01.06.2014 | Original Paper

pH sensitive nanocomposite hydrogel beads based on carboxymethyl cellulose/layered double hydroxide as drug delivery systems

verfasst von: Soroush Barkhordari, Mehdi Yadollahi, Hassan Namazi

Erschienen in: Journal of Polymer Research | Ausgabe 6/2014

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Abstract

In this paper new pH sensitive nanocomposite beads were prepared by the combination of layered double hydroxides (LDH) and carboxymethyl cellulose (CMC). Ibuprofen (IBU), as a model drug, was intercalated between LDH layers through the co-precipitation method. The synthesized LDH-IBU nanohybrids and nanocomposites beads were characterized using FTIR, XRD, and SEM. In vitro tests of drug delivery in conditions simulating the gastrointestinal tract were carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system (DDS). The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for new nanocomposite beads.
Vorheriger Artikel pH-responsive CMC/PAM/PVP semi-IPN hydrogels for theophylline drug release
Nächster Artikel Synthesis of dual thermoresponsive and pH-sensitive hollow nanospheres by atom transfer radical polymerization

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Metadaten
Titel
pH sensitive nanocomposite hydrogel beads based on carboxymethyl cellulose/layered double hydroxide as drug delivery systems
verfasst von
Soroush Barkhordari
Mehdi Yadollahi
Hassan Namazi
Publikationsdatum
01.06.2014
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 6/2014
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-014-0454-z

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