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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 9/2014

01.09.2014 | Original Paper

In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer

verfasst von: Laxmi Upadhyaya, Jay Singh, Vishnu Agarwal, A.C. Pandey, Shiv P. Verma, Parimal Das, R. P. Tewari

Erschienen in: Journal of Polymer Research | Ausgabe 9/2014

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Abstract

In this present manuscript, zinc oxide (ZnO) nanoparticles embedded carboxymethyl cellulose (CMC) bionanocomposite were prepared by in situ grafting and the hydrophobic anticancer drug curcumin (Cur) was loaded into it. Structural, morphological, and physiochemical behavior of prepared curcumin-loaded CMC/ZnO nanocomposites (NCs) were characterized by FTIR, XRD, SEM, TEM, TGA, and DTA. The drug entrapment efficiency was evaluated and the in vitro efficacy as anticancer drug delivery vehicle was analyzed. The potential toxicity of curcumin-loaded ZnO/CMC NCs (Cur/ZnO/CMC NCs) was studied by using L929 and MA104 cell lines via MTT assay. The cellular uptake study of Cur/ZnO/CMC NCs by normal (L929) and cancer (MA104) cells carried out by using ethanol extraction and by FACS analysis has been reported. The results of this investigation demonstrate that the nanomatrix synthesized can effectively deliver the anticancer drug curcumin, and hence appears to be a promising nanoformulation for anticancer therapy and other biomedical applications.
Vorheriger Artikel Well-defined poly(DL-lactide)-b-poly(N-vinylcaprolactam) copolymers: synthesis, solution properties and in vitro degradation
Nächster Artikel Synthesis of hyperbranched conjugated polymers based on 3-hexylthiophene, triphenylamine and benzo [c] [1,2,5] thiadiazole moieties: convenient synthesis through suzuki polymerization and impact of structures on optical properties

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Metadaten
Titel
In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer
verfasst von
Laxmi Upadhyaya
Jay Singh
Vishnu Agarwal
A.C. Pandey
Shiv P. Verma
Parimal Das
R. P. Tewari
Publikationsdatum
01.09.2014
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 9/2014
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-014-0550-0

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