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Journal of Sol-Gel Science and Technology
Erschienen in: Journal of Sol-Gel Science and Technology 3/2014

01.12.2014 | Original Paper

Solubility enhancement of ibuprofen using tri-ureasil-PPO hybrid: structural, cytotoxic, and drug release investigation

verfasst von: Beatriz B. Caravieri, Pollyanna F. de Oliveira, Ricardo A. Furtado, Denise C. Tavares, Eduardo J. Nassar, Katia J. Ciuffi, Eduardo F. Molina

Erschienen in: Journal of Sol-Gel Science and Technology | Ausgabe 3/2014

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Abstract

Herein, we used tri-ureasil organic–inorganic hybrid material (tU5000) in order to enhance the solubility of nonsteroidal anti-inflammatory drugs and fine tuning the drug delivery profile. For the first time, we used tU5000 as a film-forming agent in order to provide an alternative vehicle for transdermal drug delivery systems which the cell viability of practically 100 % for the highest and the lowest tested concentrations of pure tU5000 indicated that the material was not cytotoxic. The physicochemical properties of the tU5000 drug carrier and drug-loaded hybrids were systematically studied using powder X-ray diffraction, differential scanning calorimetry, small-angle X-ray scattering, and Fourier-transform infrared spectroscopy. The structural changes of tU5000 as well as the relationships between the drug content and in vitro drug release behaviors were investigated. The results showed that the ibu molecules were homogeneously distributed in the tU5000 xerogels contributing to fine-tuning the drug delivery profile. Considering the ability to incorporated high drug content, simple and mild preparation procedure by one-pot sol–gel route, high stability of the materials, sustained-release property, this class of hybrid based on polymers and inorganic compounds may have potential applications in the design of pharmaceutical formulation as ophthalmic (contact lenses), transdermal (patches) and implantable (soft tissue) drug delivery systems.
Vorheriger Artikel Sol–gel synthesis of nanocrystalline Zn1−xNixFe2O4 ceramics and its structural, magnetic and dielectric properties
Nächster Artikel Synthesis and characterization of NaA zeolite powder/film deposited on alumina beads by dip-coating method

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Metadaten
Titel
Solubility enhancement of ibuprofen using tri-ureasil-PPO hybrid: structural, cytotoxic, and drug release investigation
verfasst von
Beatriz B. Caravieri
Pollyanna F. de Oliveira
Ricardo A. Furtado
Denise C. Tavares
Eduardo J. Nassar
Katia J. Ciuffi
Eduardo F. Molina
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Journal of Sol-Gel Science and Technology / Ausgabe 3/2014
Print ISSN: 0928-0707
Elektronische ISSN: 1573-4846
DOI
https://doi.org/10.1007/s10971-014-3485-3

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