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Erschienen in: Lifetime Data Analysis 2/2014

01.04.2014

Pseudo-observations for competing risks with covariate dependent censoring

verfasst von: Nadine Binder, Thomas A. Gerds, Per Kragh Andersen

Erschienen in: Lifetime Data Analysis | Ausgabe 2/2014

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Abstract

Regression analysis for competing risks data can be based on generalized estimating equations. For the case with right censored data, pseudo-values were proposed to solve the estimating equations. In this article we investigate robustness of the pseudo-values against violation of the assumption that the probability of not being lost to follow-up (un-censored) is independent of the covariates. Modified pseudo-values are proposed which rely on a correctly specified regression model for the censoring times. Bias and efficiency of these methods are compared in a simulation study. Further illustration of the differences is obtained in an application to bone marrow transplantation data and a corresponding sensitivity analysis.

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Metadaten
Titel
Pseudo-observations for competing risks with covariate dependent censoring
verfasst von
Nadine Binder
Thomas A. Gerds
Per Kragh Andersen
Publikationsdatum
01.04.2014
Verlag
Springer US
Erschienen in
Lifetime Data Analysis / Ausgabe 2/2014
Print ISSN: 1380-7870
Elektronische ISSN: 1572-9249
DOI
https://doi.org/10.1007/s10985-013-9247-7

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