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2013 | OriginalPaper | Buchkapitel

Spatial Aspects of HIV Infection

verfasst von : Frederik Graw, Alan S. Perelson

Erschienen in: Mathematical Methods and Models in Biomedicine

Verlag: Springer New York

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Abstract

Human immunodeficiency virus type 1 (HIV-1) is one of the most and intensely studied viral pathogens in the history of science. However, despite the huge scientific effort, many aspects of HIV infection dynamics and disease pathogenesis within a host are still not understood. Mathematical modeling has helped to improve our understanding of the infection as well as the dynamics of the immune response. Fitting models to clinical data has provided estimates for the turnover rate of target cells [82, 83,111], the lifetime of infected cells and viral particles [104, 109], as well as for the rate of viral production by infected cells [21, 44]. Most mathematical models applied to experimental data on viral infections have been formulated as systems of ordinary differential equations (ODE) [91, 101, 104].

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Nächstes Kapitel Basic Principles in Modeling Adaptive Regulation and Immunodominance
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Metadaten
Titel
Spatial Aspects of HIV Infection
verfasst von
Frederik Graw
Alan S. Perelson
Copyright-Jahr
2013
Verlag
Springer New York
Buch
Mathematical Methods and Models in Biomedicine

Print ISBN: 978-1-4614-4177-9

Electronic ISBN: 978-1-4614-4178-6

Copyright-Jahr: 2013

DOI
https://doi.org/10.1007/978-1-4614-4178-6_1

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