Boundary and Entropy-Driven Adversarial Learning for Fundus Image Segmentation

Accurate segmentation of the optic disc (OD) and cup (OC) in fundus images from different datasets is critical for glaucoma disease screening. The cross-domain discrepancy (domain shift) hinders the generalization of deep neural networks to work on different domain datasets. In this work, we present an unsupervised domain adaptation framework, called Boundary and Entropy-driven Adversarial Learning (BEAL), to improve the OD and OC segmentation performance, especially on the ambiguous boundary regions. In particular, our proposed BEAL framework utilizes the adversarial learning to encourage the boundary prediction and mask probability entropy map (uncertainty map) of the target domain to be similar to the source ones, generating more accurate boundaries and suppressing the high uncertainty predictions of OD and OC segmentation. We evaluate the proposed BEAL framework on two public retinal fundus image datasets (Drishti-GS and RIM-ONE-r3), and the experiment results demonstrate that our method outperforms the state-of-the-art unsupervised domain adaptation methods. Our code is available at https://​github.​com/​EmmaW8/​BEAL.