Skip to main content

2010 | OriginalPaper | Buchkapitel

Resonant Waveguide Grating Biosensor for Microarrays

verfasst von : Ye Fang

Erschienen in: Optical Guided-wave Chemical and Biosensors II

Verlag: Springer Berlin Heidelberg

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

A microarray consists of an indexed series of micron-sized spots of biological specimens for biomolecular interaction analysis. Microarray technologies present miniaturized and multiplexed approaches for sensitive and selective profiling of genes, proteins, and/or small molecules. Concurrent with the increasing applications of microarrays is the continuous efforts in developing novel detection systems for improving sensitivity and reliability in signal detection. This chapter describes the concept and applications of microarray technologies, and the principle of detection with an emphasis of resonant waveguide grating biosensor for microarray-based assays.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Bally M, Halter M, Vöros J, Grandin HM (2006) Optical microarray biosensing techniques. Surf Interface Anal 38:1442–1458CrossRef Bally M, Halter M, Vöros J, Grandin HM (2006) Optical microarray biosensing techniques. Surf Interface Anal 38:1442–1458CrossRef
2.
Zurück zum Zitat Bertone P, Snyder M (2005) Advances in functional protein microarray technology. FEBS J 272:5400–5411CrossRef Bertone P, Snyder M (2005) Advances in functional protein microarray technology. FEBS J 272:5400–5411CrossRef
3.
Zurück zum Zitat Bochner BS, Alvarez RA, Mehta P, Bovin NV, Blixt O, White JR, Schnaar RL (2005) Glycan array screening reveals a candidate ligand for Siglect-8. J Biol Chem 280:4307–4312CrossRef Bochner BS, Alvarez RA, Mehta P, Bovin NV, Blixt O, White JR, Schnaar RL (2005) Glycan array screening reveals a candidate ligand for Siglect-8. J Biol Chem 280:4307–4312CrossRef
4.
Zurück zum Zitat Budach W, Abel AP, Bruno AE, Neuschafer D (1999) Planar waveguides as high performance sensing platforms for fluorescence-based multiplexed oligonucleotide hybridization assays. Anal Chem 71:3347–3355CrossRef Budach W, Abel AP, Bruno AE, Neuschafer D (1999) Planar waveguides as high performance sensing platforms for fluorescence-based multiplexed oligonucleotide hybridization assays. Anal Chem 71:3347–3355CrossRef
5.
Zurück zum Zitat Chen DS, Davis MM (2006) Molecular and functional analysis using live cell microarrays. Curr Opin Chem Biol 10:28–34CrossRef Chen DS, Davis MM (2006) Molecular and functional analysis using live cell microarrays. Curr Opin Chem Biol 10:28–34CrossRef
6.
Zurück zum Zitat Cooper MA (2006) Optical biosensors: where next and how soon. Drug Discov Today 11:1061–1067CrossRef Cooper MA (2006) Optical biosensors: where next and how soon. Drug Discov Today 11:1061–1067CrossRef
7.
Zurück zum Zitat Delehanty JB (2004) Printing functional protein microarrays using piezoelectric capillaries. Methods Mol Biol 264:135–143 Delehanty JB (2004) Printing functional protein microarrays using piezoelectric capillaries. Methods Mol Biol 264:135–143
8.
Zurück zum Zitat Drews J (2000) Drug discovery: a historical perspective. Science 287:1960–1963CrossRef Drews J (2000) Drug discovery: a historical perspective. Science 287:1960–1963CrossRef
9.
Zurück zum Zitat Duveneck GL, Pawlak M, Neuschafer D, Bar E, Budach W, Pieles U, Ehrat M (1997) Novel bioaffinity sensors for trace analysis based on luminescence excitation by planar waveguides. Sensors Actuators B Chem 38:88–95CrossRef Duveneck GL, Pawlak M, Neuschafer D, Bar E, Budach W, Pieles U, Ehrat M (1997) Novel bioaffinity sensors for trace analysis based on luminescence excitation by planar waveguides. Sensors Actuators B Chem 38:88–95CrossRef
10.
Zurück zum Zitat Duveneck GL, Bopp MA, Ehrat M, Balet LP, Haiml M, Keller U, Marowsky G, Soria S (2003) Two-photon fluorescence excitation of macroscopic areas on planar waveguides. Biosens Bioelectron 18:503–510CrossRef Duveneck GL, Bopp MA, Ehrat M, Balet LP, Haiml M, Keller U, Marowsky G, Soria S (2003) Two-photon fluorescence excitation of macroscopic areas on planar waveguides. Biosens Bioelectron 18:503–510CrossRef
11.
Zurück zum Zitat Fang Y (2006) Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol 4:583–595CrossRef Fang Y (2006) Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol 4:583–595CrossRef
12.
Zurück zum Zitat Fang Y (2007) Non-invasive optical biosensor for probing cell signaling. Sensors 7:2316–2329CrossRef Fang Y (2007) Non-invasive optical biosensor for probing cell signaling. Sensors 7:2316–2329CrossRef
13.
Zurück zum Zitat Fang Y, Ferrie AM (2007) Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells. BMC Cell Biol 8:e24CrossRef Fang Y, Ferrie AM (2007) Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells. BMC Cell Biol 8:e24CrossRef
14.
Zurück zum Zitat Fang Y, Ferrie AM (2008) Label-free optical biosensor for ligand-directed functional selectivity acting on β2 adrenoceptor in living cells. FEBS Lett 582:558–564CrossRef Fang Y, Ferrie AM (2008) Label-free optical biosensor for ligand-directed functional selectivity acting on β2 adrenoceptor in living cells. FEBS Lett 582:558–564CrossRef
15.
Zurück zum Zitat Fang Y, Frutos AG, Lahiri J (2002) Membrane protein microarrays. J Am Chem Soc 124:2394–2395CrossRef Fang Y, Frutos AG, Lahiri J (2002) Membrane protein microarrays. J Am Chem Soc 124:2394–2395CrossRef
16.
Zurück zum Zitat Fang Y, Frutos AG, Lahiri J (2003) Ganglioside microarrays for toxin detection. Langmuir 19:1500–1505CrossRef Fang Y, Frutos AG, Lahiri J (2003) Ganglioside microarrays for toxin detection. Langmuir 19:1500–1505CrossRef
17.
Zurück zum Zitat Fang Y, Lahiri J, Picard L (2003) G protein-coupled receptor microarrays for drug discovery. Drug Discov Today 8:755–761CrossRef Fang Y, Lahiri J, Picard L (2003) G protein-coupled receptor microarrays for drug discovery. Drug Discov Today 8:755–761CrossRef
18.
Zurück zum Zitat Fang Y, Ferrie AM, Fontaine NH, Yuen PK (2005) Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors. Anal Chem 77:5720–5725CrossRef Fang Y, Ferrie AM, Fontaine NH, Yuen PK (2005) Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors. Anal Chem 77:5720–5725CrossRef
19.
Zurück zum Zitat Fang Y, Li G, Peng J (2005) Optical biosensor provides insights for bradykinin B2 receptor signaling in A431 cells. FEBS Lett 579:6365–6374CrossRef Fang Y, Li G, Peng J (2005) Optical biosensor provides insights for bradykinin B2 receptor signaling in A431 cells. FEBS Lett 579:6365–6374CrossRef
20.
Zurück zum Zitat Fang Y, Ferrie AM, Fontaine NH, Mauro J, Balakrishnan J (2006) Resonant waveguide grating biosensor for living cell sensing. Biophys J 91:1925–1940CrossRef Fang Y, Ferrie AM, Fontaine NH, Mauro J, Balakrishnan J (2006) Resonant waveguide grating biosensor for living cell sensing. Biophys J 91:1925–1940CrossRef
21.
Zurück zum Zitat Fang Y, Peng J, Ferrie AM, Burkhalter RS (2006) Air-stable G protein-coupled receptor microarrays and ligand binding characteristics. Anal Chem 78:149–155CrossRef Fang Y, Peng J, Ferrie AM, Burkhalter RS (2006) Air-stable G protein-coupled receptor microarrays and ligand binding characteristics. Anal Chem 78:149–155CrossRef
22.
Zurück zum Zitat Fang Y, Li G, Ferrie AM (2007) Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J Pharmacol Toxicol Methods 55:314–322CrossRef Fang Y, Li G, Ferrie AM (2007) Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J Pharmacol Toxicol Methods 55:314–322CrossRef
23.
Zurück zum Zitat Francois P, Charbonnier Y, Jacquet J, Utinger D, Bento M, Lew D, Kresbach GM, Ehrat M, Schlegel W, Schrenzel J (2006) Rapid bacterial identification using evanescent-waveguide oligonucleotide microarray classification. J Microbiol Methods 65:390–403CrossRef Francois P, Charbonnier Y, Jacquet J, Utinger D, Bento M, Lew D, Kresbach GM, Ehrat M, Schlegel W, Schrenzel J (2006) Rapid bacterial identification using evanescent-waveguide oligonucleotide microarray classification. J Microbiol Methods 65:390–403CrossRef
24.
Zurück zum Zitat Fukui S, Feizi T, Galustian C, Lawson AM, Chai W (2002) Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions. Nat Biotechnol 20:1011–1017CrossRef Fukui S, Feizi T, Galustian C, Lawson AM, Chai W (2002) Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions. Nat Biotechnol 20:1011–1017CrossRef
25.
Zurück zum Zitat Grandin HM, Stadler B, Textor M, Voros J (2006) Waveguide excitation fluorescence microscopy: a new tool for sensing and imaging the biointerface. Biosens Bioelectron 21:1476–1482CrossRef Grandin HM, Stadler B, Textor M, Voros J (2006) Waveguide excitation fluorescence microscopy: a new tool for sensing and imaging the biointerface. Biosens Bioelectron 21:1476–1482CrossRef
26.
Zurück zum Zitat Hall DA, Zhu H, Zhu X, Royce T, Gerstein M, Snyder M (2004) Regulation of gene expression by a metabolic enzyme. Science 306:482–484CrossRef Hall DA, Zhu H, Zhu X, Royce T, Gerstein M, Snyder M (2004) Regulation of gene expression by a metabolic enzyme. Science 306:482–484CrossRef
27.
Zurück zum Zitat He M, Wang MW (2007) Arraying proteins by cell-free synthesis. Biomol Eng 24:375–380CrossRef He M, Wang MW (2007) Arraying proteins by cell-free synthesis. Biomol Eng 24:375–380CrossRef
28.
Zurück zum Zitat Hook AL, Thissen H, Voelcker NH (2006) Surface manipulation of biomolecules for cell microarray applications. Trends Biotechnol 24:471–477CrossRef Hook AL, Thissen H, Voelcker NH (2006) Surface manipulation of biomolecules for cell microarray applications. Trends Biotechnol 24:471–477CrossRef
29.
Zurück zum Zitat Hopkins AL, Groom CR (2002) The druggable genome. Nat Rev Drug Discov 1:727–730CrossRef Hopkins AL, Groom CR (2002) The druggable genome. Nat Rev Drug Discov 1:727–730CrossRef
30.
Zurück zum Zitat Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL (2004) Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci USA 101:16594–16599CrossRef Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL (2004) Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci USA 101:16594–16599CrossRef
31.
Zurück zum Zitat Ivanov SS, Chung AS, Yuan ZL, Guan YJ, Sachs KV, Reichner JS, Chin YE (2004) Antibodies immobilized as arrays to profile protein post-translational modifications in mammalian cells. Mol Cell Proteomics 3:788–795CrossRef Ivanov SS, Chung AS, Yuan ZL, Guan YJ, Sachs KV, Reichner JS, Chin YE (2004) Antibodies immobilized as arrays to profile protein post-translational modifications in mammalian cells. Mol Cell Proteomics 3:788–795CrossRef
32.
Zurück zum Zitat Jones RB, Gordus A, Krall JA, MacBeath G (2006) A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439:168–174CrossRef Jones RB, Gordus A, Krall JA, MacBeath G (2006) A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439:168–174CrossRef
33.
Zurück zum Zitat Li PY, Lin B, Gerstenmaier J, Cunningham B (2004) A new method for label-free imaging of biomolecular interactions. Sensors Actuators B Chem 99:6–13CrossRef Li PY, Lin B, Gerstenmaier J, Cunningham B (2004) A new method for label-free imaging of biomolecular interactions. Sensors Actuators B Chem 99:6–13CrossRef
34.
Zurück zum Zitat Li G, Ferrie AM, Fang Y (2006) Label-free profiling of endogenous G protein-coupled receptors using a cell-based high throughput screening technology. J Assoc Lab Autom 11:181–187CrossRef Li G, Ferrie AM, Fang Y (2006) Label-free profiling of endogenous G protein-coupled receptors using a cell-based high throughput screening technology. J Assoc Lab Autom 11:181–187CrossRef
35.
Zurück zum Zitat Liang PH, Wu CY, Greenberg WA, Wong CH (2008) Glycan arrays: biological and medical applications. Curr Opin Chem Biol 12:1–7CrossRef Liang PH, Wu CY, Greenberg WA, Wong CH (2008) Glycan arrays: biological and medical applications. Curr Opin Chem Biol 12:1–7CrossRef
36.
Zurück zum Zitat Lin B, Gerstenmeier J, Li P, Pien H, Pepper J, Cunningham BA (2002) Label-free optical technique for detecting small molecule interactions. Biosens Bioelectron 17:827–834CrossRef Lin B, Gerstenmeier J, Li P, Pien H, Pepper J, Cunningham BA (2002) Label-free optical technique for detecting small molecule interactions. Biosens Bioelectron 17:827–834CrossRef
37.
Zurück zum Zitat MacBeath G, Schreiber SL (2000) Printing proteins as microarrays for high throughput function determination. Science 289:1760–1763 MacBeath G, Schreiber SL (2000) Printing proteins as microarrays for high throughput function determination. Science 289:1760–1763
38.
Zurück zum Zitat Miller JC, Zhou H, Kwekel J, Cavallo R, Burke J, Butler EB, Teh BS, Haab BB (2003) Antibody microarray profiling of human prostate cancer sera: antibody screening and identification of potential biomarkers. Proteomics 3:56–63CrossRef Miller JC, Zhou H, Kwekel J, Cavallo R, Burke J, Butler EB, Teh BS, Haab BB (2003) Antibody microarray profiling of human prostate cancer sera: antibody screening and identification of potential biomarkers. Proteomics 3:56–63CrossRef
39.
Zurück zum Zitat Mishina YM, Wilson CJ, Bruett L, Smith JJ, Stoop-Myer C, Jong S, Amaral LP, Pedersen R, Lyman SK, Myer VE, Kreider BL, Thompson CM (2004) Multiplex GPCR assay in reverse transfection cell microarrays. J Biomol Screen 9:196–207CrossRef Mishina YM, Wilson CJ, Bruett L, Smith JJ, Stoop-Myer C, Jong S, Amaral LP, Pedersen R, Lyman SK, Myer VE, Kreider BL, Thompson CM (2004) Multiplex GPCR assay in reverse transfection cell microarrays. J Biomol Screen 9:196–207CrossRef
40.
Zurück zum Zitat Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK (2003) Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci USA 100:9330–9335CrossRef Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK (2003) Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci USA 100:9330–9335CrossRef
41.
Zurück zum Zitat Pawlak M, Schick E, Bopp MA, Schneider MJ, Oroszlan P, Ehrat M (2002) Zeptosens’ protein microarrays: a novel high performance microarray platform for low abundance protein analysis. Proteomics 2:383–393CrossRef Pawlak M, Schick E, Bopp MA, Schneider MJ, Oroszlan P, Ehrat M (2002) Zeptosens’ protein microarrays: a novel high performance microarray platform for low abundance protein analysis. Proteomics 2:383–393CrossRef
42.
Zurück zum Zitat Pease AC, Solas D, Sullivan EJ, Cronin MT, Holmes CP, Fodor SP (1994) Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci USA 91:5022–5026CrossRef Pease AC, Solas D, Sullivan EJ, Cronin MT, Holmes CP, Fodor SP (1994) Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci USA 91:5022–5026CrossRef
43.
Zurück zum Zitat Pilobello KT, Mahal L (2007) Deciphering the glycocode: the complexity and analytical challenge of glycomics. Curr Opin Chem Biol 11:300–305CrossRef Pilobello KT, Mahal L (2007) Deciphering the glycocode: the complexity and analytical challenge of glycomics. Curr Opin Chem Biol 11:300–305CrossRef
44.
Zurück zum Zitat Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, Williams CF, Jeffrey SS, Botstein D, Brown PO (1999) Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet 23:41–46CrossRef Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, Williams CF, Jeffrey SS, Botstein D, Brown PO (1999) Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet 23:41–46CrossRef
45.
Zurück zum Zitat Ramachandran N, Larson DN, Stark PRH, Hainsworth E, LaBear J (2005) Emerging tools for real-time label-free detection of interactions on functional protein microarrays. FASEB J 272:5412–5425 Ramachandran N, Larson DN, Stark PRH, Hainsworth E, LaBear J (2005) Emerging tools for real-time label-free detection of interactions on functional protein microarrays. FASEB J 272:5412–5425
46.
Zurück zum Zitat Rich RL, Myszka DG (2007) Higher-throughput, label-free, real-time molecular interaction analysis. Anal Biochem 361:1–6CrossRef Rich RL, Myszka DG (2007) Higher-throughput, label-free, real-time molecular interaction analysis. Anal Biochem 361:1–6CrossRef
47.
Zurück zum Zitat Rothenhausler B, Knoll W (1988) Surface–plasmon microscopy. Nature 332:615–617CrossRef Rothenhausler B, Knoll W (1988) Surface–plasmon microscopy. Nature 332:615–617CrossRef
48.
Zurück zum Zitat Sassolas A, Leca-Bouvier BD, Blum J (2008) DNA biosensors and microarrays. Chem Rev 108:109–139CrossRef Sassolas A, Leca-Bouvier BD, Blum J (2008) DNA biosensors and microarrays. Chem Rev 108:109–139CrossRef
49.
Zurück zum Zitat Schena M, Shalon D, Davis RW, Brown PO (1995) Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467–470CrossRef Schena M, Shalon D, Davis RW, Brown PO (1995) Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467–470CrossRef
50.
Zurück zum Zitat Shalon D, Smith SJ, Brown PO (1996) A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Res 6:639–645CrossRef Shalon D, Smith SJ, Brown PO (1996) A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Res 6:639–645CrossRef
51.
Zurück zum Zitat Sreekumar A, Nyati MK, Varambally S, Barrette TR, Ghosh D, Lawrence TS, Chinnaiyan AM (2001) Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res 61:7585–7593 Sreekumar A, Nyati MK, Varambally S, Barrette TR, Ghosh D, Lawrence TS, Chinnaiyan AM (2001) Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res 61:7585–7593
52.
Zurück zum Zitat Tiefenthaler K, Lukosz W (1989) Sensitivity of grating couplers as integrated-optical chemical sensors. J Opt Soc Am B 6:209–220CrossRef Tiefenthaler K, Lukosz W (1989) Sensitivity of grating couplers as integrated-optical chemical sensors. J Opt Soc Am B 6:209–220CrossRef
53.
Zurück zum Zitat Usui-Aoki K, Shimada K, Nagano M, Kawai M, Koga H (2005) A novel approach to protein expression proWling using antibody microarrays combined with surface plasmon resonance technology. Proteomics 5:2396–2401CrossRef Usui-Aoki K, Shimada K, Nagano M, Kawai M, Koga H (2005) A novel approach to protein expression proWling using antibody microarrays combined with surface plasmon resonance technology. Proteomics 5:2396–2401CrossRef
54.
Zurück zum Zitat Wheeler DB, Carpenter AE, Sabatini DM (2005) Cell microarrays and RNA interference chip away at gene function. Nat Genet 37:S25–S30CrossRef Wheeler DB, Carpenter AE, Sabatini DM (2005) Cell microarrays and RNA interference chip away at gene function. Nat Genet 37:S25–S30CrossRef
55.
Zurück zum Zitat Wilson R, Cossins AR, Spiller DG (2006) Encoded microcarriers for high-throughput multiplexed detection. Angew Chem Int Ed 45:6104–6117CrossRef Wilson R, Cossins AR, Spiller DG (2006) Encoded microcarriers for high-throughput multiplexed detection. Angew Chem Int Ed 45:6104–6117CrossRef
56.
Zurück zum Zitat Yeatman EM (1996) Resolution and sensitivity in surface plasmon microscopy and sensing. Biosens Bioelectron 11:635–649CrossRef Yeatman EM (1996) Resolution and sensitivity in surface plasmon microscopy and sensing. Biosens Bioelectron 11:635–649CrossRef
57.
Zurück zum Zitat Yuk JS, Jung SH, Jung JW, Hong DG, Han JA, Kim YM, Ha KS (2004) Analysis of protein interactions on protein arrays by a wavelength interrogation-based surface plasmon resonance biosensor. Proteomics 4:3468–3476CrossRef Yuk JS, Jung SH, Jung JW, Hong DG, Han JA, Kim YM, Ha KS (2004) Analysis of protein interactions on protein arrays by a wavelength interrogation-based surface plasmon resonance biosensor. Proteomics 4:3468–3476CrossRef
58.
Zurück zum Zitat Zhu H, Klemic JF, Chang S, Bertone P, Casamayor A, Klemic KG, Smith D, Gerstein M, Reed MA, Snyder M (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26:283–289CrossRef Zhu H, Klemic JF, Chang S, Bertone P, Casamayor A, Klemic KG, Smith D, Gerstein M, Reed MA, Snyder M (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26:283–289CrossRef
59.
Zurück zum Zitat Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean RA, Gerstein M, Snyder M (2001) Global analysis of protein activities using proteome chips. Science 293:2101–2105CrossRef Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean RA, Gerstein M, Snyder M (2001) Global analysis of protein activities using proteome chips. Science 293:2101–2105CrossRef
60.
Zurück zum Zitat Ziauddin J, Sabatini DM (2001) Microarrays of cells expressing defined cDNA. Nature 411:107–110CrossRef Ziauddin J, Sabatini DM (2001) Microarrays of cells expressing defined cDNA. Nature 411:107–110CrossRef
Metadaten
Titel
Resonant Waveguide Grating Biosensor for Microarrays
verfasst von
Ye Fang
Copyright-Jahr
2010
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-02827-4_2

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.