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Polymer Bulletin
Erschienen in: Polymer Bulletin 4/2009

01.04.2009 | Original Paper

Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour

verfasst von: Anca Bejenariu, Marcel Popa, Virginie Dulong, Luc Picton, Didier Le Cerf

Erschienen in: Polymer Bulletin | Ausgabe 4/2009

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Abstract

Xanthan (Xan) is a biocompatible and biodegradable polysaccharide with a promising potential as substrate for controlled drug delivery applications. Xan based hydrogels were synthesized in alkaline medium using trisodium trimetaphosphate (STMP) as crosslinking agent. Hydrogels with various crosslinking agent/polymer ratios were synthesized and subsequently characterized by the means of elemental analysis and dynamic swelling degree, model compound loading and releasing behaviour. Two physical parameters (crosslinking density and phosphate charge) are manifesting antagonistic actions by stiffening or disrupting the three-dimensional macromolecular ensemble. The highest swelling degree was obtained using an intermediate STMP:Xan ratio in which case the opposing effects of the two forces are well balanced. The synthesized networks are pH sensitive. In acid and alkaline media the swelling degrees are lower by comparison to neutral pH. The entrapping and releasing behaviour of the newly synthesized xanthan networks were studied using methylene blue as a cationic model molecule. The releasing kinetics present a first-order model.
Vorheriger Artikel Colloidal Cu nanoparticles/chitosan composite film obtained by microwave heating for food package applications
Nächster Artikel Polyacrylamide-gelatin polymeric networks: effect of pH and gelatin concentration on the swelling kinetics and mechanical properties

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Metadaten
Titel
Trisodium trimetaphosphate crosslinked xanthan networks: synthesis, swelling, loading and releasing behaviour
verfasst von
Anca Bejenariu
Marcel Popa
Virginie Dulong
Luc Picton
Didier Le Cerf
Publikationsdatum
01.04.2009
Verlag
Springer-Verlag
Erschienen in
Polymer Bulletin / Ausgabe 4/2009
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-008-0033-8

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