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Colloid and Polymer Science

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01.04.2014 | Original Contribution

Inclusion complexes of rosmarinic acid and cyclodextrins: stoichiometry, association constants, and antioxidant potential

verfasst von: Bruno Medronho, Artur J. M. Valente, Patrícia Costa, Anabela Romano

Erschienen in: Colloid and Polymer Science | Ausgabe 4/2014

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Abstract

The interaction between β-cyclodextrin (β-CD) and the polyphenol rosmarinic acid (RA) is here reported by ¹H NMR titration experiments. The formation of an aqueous soluble inclusion complex is confirmed and valuable information regarding mode of penetration of guest into β-CD, stoichiometry, and stability of the complex is obtained. The analysis by the continuous variation method shows the undoubted formation of 1:1 β-CD/RA complex. Additionally, the estimated apparent association constants reveal the importance of the asymmetry of the RA in the complexation; the incorporation of the catechol moiety closer to the carboxylic group is more favorable (K = 2,028 M⁻¹) than from the other end of the RA molecule (K = 1,184 M⁻¹). Finally, we have also investigated the antioxidant activity and storage stability of the β-CD/RA complexed system; the presence of β-CD was found to produce a remarkable enhancement on the antioxidant activity.

Vorheriger Artikel Synthesis of nonionic polyurethanes with hydroxyl-terminated polybutadiene hydrophobic segments and their application in octadecane nanocapsules

Nächster Artikel Research on association between multi-sticker amphiphilic polymer and water-soluble β-cyclodextrin polymer

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Titel: Inclusion complexes of rosmarinic acid and cyclodextrins: stoichiometry, association constants, and antioxidant potential
verfasst von: Bruno Medronho
Artur J. M. Valente
Patrícia Costa
Anabela Romano
Publikationsdatum: 01.04.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Colloid and Polymer Science / Ausgabe 4/2014
Print ISSN: 0303-402X
Elektronische ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-013-3124-5

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